Gene Symbol: TIMP3
Description: TIMP metallopeptidase inhibitor 3
Alias: TIMP-3, metalloproteinase inhibitor 3, TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory), tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory), tissue inhibitor of metalloproteinases 3
Species: cow
Products:     TIMP3

Top Publications

  1. Criado M, Alamo L, Navarro A. Primary structure of an agonist binding subunit of the nicotinic acetylcholine receptor from bovine adrenal chromaffin cells. Neurochem Res. 1992;17:281-7 pubmed
  2. Li W, Qureshi H, Liacini A, Dehnade F, Zafarullah M. Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species. Free Radic Biol Med. 2004;37:196-207 pubmed
    ..TGF-beta1 induces tissue inhibitor of metalloproteinases 3 (TIMP-3), an inhibitor of cartilage-damaging matrix metalloproteianases and aggrecanases...
  3. Grad S, Gogolewski S, Alini M, Wimmer M. Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds. Tissue Eng. 2006;12:3171-9 pubmed
    ..It is suggested that the oscillating ball drags the fluid into the joint space, thereby causing biophysical effects similar to those of fluid flow. ..
  4. Su S, Dehnade F, Zafarullah M. Regulation of tissue inhibitor of metalloproteinases-3 gene expression by transforming growth factor-beta and dexamethasone in bovine and human articular chondrocytes. DNA Cell Biol. 1996;15:1039-48 pubmed
    ..TIMP-3 induction by TGF-beta suggests the role of this factor and TIMP-3 in cartilage remodeling with important implications for arthritis. ..
  5. Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed
  6. Saunders W, Bohnsack B, Faske J, Anthis N, Bayless K, Hirschi K, et al. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol. 2006;175:179-91 pubmed