Gene Symbol: TIMP1
Description: TIMP metallopeptidase inhibitor 1
Alias: metalloproteinase inhibitor 1, EG-1, TIMP-1, embryogenin-1, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor), tissue inhibitor of metalloproteinases 1
Species: cow
Products:     TIMP1

Top Publications

  1. Freudenstein J, Wagner S, Luck R, Einspanier R, Scheit K. mRNA of bovine tissue inhibitor of metalloproteinase: sequence and expression in bovine ovarian tissue. Biochem Biophys Res Commun. 1990;171:250-6 pubmed
    ..Expression varies with the stage of the luteal phase; it was highest in stages I and III, but low in stages II and IV of the oestrous cycle. ..
  2. De Clerck Y, Yean T, Ratzkin B, Lu H, Langley K. Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells. J Biol Chem. 1989;264:17445-53 pubmed
    ..The presence of these inhibitors in endothelial cells suggests that they may play important roles in protecting the integrity of the vascular basement membrane. ..
  3. Satoh T, Kobayashi K, Yamashita S, Kikuchi M, Sendai Y, Hoshi H. Tissue inhibitor of metalloproteinases (TIMP-1) produced by granulosa and oviduct cells enhances in vitro development of bovine embryo. Biol Reprod. 1994;50:835-44 pubmed
    ..These data suggest that the tissue inhibitor of metalloproteinase-1 produced by BGC and BOEC is a major ESA for in vitro development of bovine embryos. ..
  4. Wang X, Wang H, Aodon geril -, Shu Y, Momotani Y, Nagata R, et al. Decreased expression of matrix metalloproteinase-9 and increased expression of tissue inhibitors of matrix metalloproteinase-1 in paratuberculosis-infected cattle in the ELISA-negative subclinical stage. Anim Biotechnol. 2011;22:44-9 pubmed publisher
    ..As a result, the MMP-9 may play an important role in the development of Mycobacterium avium subsp. paratuberculosis disease. ..
  5. Reichenstein M, Reich R, LeHoux J, Hanukoglu I. ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells. Mol Cell Endocrinol. 2004;215:109-14 pubmed
    ..Overall, our results show that ACTH causes induction of TIMP-1 and suppression of collagenase activity, and suggest that ACTH may modulate the activities of MMPs and hence cell matrix remodeling. ..
  6. Nishimura K, Yamashita K, Kato Y, Iwata T, Iwata K, Nishikawa T, et al. Inhibitory activity on matrix metalloproteinases and cell-proliferating activity of tissue inhibitor of metalloproteinases-1 (TIMP-1)-contrastive difference between human and bovine TIMP-1s on mouse cell proliferation. Growth Factors. 2005;23:135-42 pubmed
    ..Human TIMP-1 seems not to bind to TIMP-1 receptors on mouse cells. ..
  7. Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed
  8. Hirata M, Sato T, Tsumagari M, Shimada A, Nakano H, Hashizume K, et al. Differential regulation of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases by cytokines and growth factors in bovine endometrial stromal cells and trophoblast cell line BT-1 in vitro. Biol Reprod. 2003;68:1276-81 pubmed
    ..Furthermore, as in humans and rodents, MMPs and TIMPs may contribute to the control of degradation and reconstitution of extracellular matrix in bovine endometrium during embryonic implantation and early placentation. ..
  9. Zhang B, Moses M, Tsang P. Temporal and spatial expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the bovine corpus luteum. Reprod Biol Endocrinol. 2003;1:85 pubmed
    ..Furthermore, the distinct localization of these two inhibitors in the vascular compartment indicates that they may serve diverse physiological functions during different stages of luteal angiogenesis. ..

More Information


  1. Mandal M, Das S, Chakraborti T, Mandal A, Chakraborti S. Identification, purification and partial characterization of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in bovine pulmonary artery smooth muscle. Mol Cell Biochem. 2003;254:145-55 pubmed
    ..It was also found to be inactive against the serine proteases trypsin and plasmin. The inhibitor was heat and acid resistant and it had the sensitivity to trypsin degradation and reduction-alkylation. ..
  2. Hirako Y, Yoshino K, Zillikens D, Owaribe K. Extracellular cleavage of bullous pemphigoid antigen 180/type XVII collagen and its involvement in hemidesmosomal disassembly. J Biochem. 2003;133:197-206 pubmed
    ..Our observations demonstrate that the cleavage of BP180 occurring within the NC16A domain is mediated by a membrane-associated metalloprotease and suggest a possible involvement of the cleavage in hemidesmosomal disassembly...
  3. Dilly M, Hambruch N, Haeger J, Pfarrer C. Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells. Mol Reprod Dev. 2010;77:622-9 pubmed publisher
    ..In conclusion, EGF-mediated effects stimulate migration and proliferation of bovine trophoblast cells and may be involved in bovine placental tissue remodeling and postpartum release of fetal membranes. ..