Gene Symbol: THBS1
Description: thrombospondin 1
Alias: THBS, thrombospondin-1
Species: cow
Products:     THBS1

Top Publications

  1. Orr A, Pallero M, Xiong W, Murphy Ullrich J. Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. J Biol Chem. 2004;279:48983-92 pubmed
    ..Cells utilize dynamic interactions with the extracellular matrix to adapt to changing environmental conditions. Thrombospondin 1 (TSP1) induces focal adhesion disassembly and cell migration through a sequence (hep I) in its heparin-..
  2. Lafeuillade B, Pellerin S, Keramidas M, Danik M, Chambaz E, Feige J. Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells. J Cell Physiol. 1996;167:164-72 pubmed
    ..This hypothesis is further supported by the observation that anti-CISP antibodies inhibit the maintenance of the morphological changes of bovine adrenocortical cells induced by ACTH, whereas anti-TSP1 antibodies do not. ..
  3. Lee T, Nesselroth S, Olson E, Esemuede N, Lawler J, Sumpio B, et al. Thrombospondin-1-induced vascular smooth muscle cell chemotaxis: the role of the type 3 repeat and carboxyl terminal domains. J Cell Biochem. 2003;89:500-6 pubmed
    ..The T2 domain had no effect on VSMC chemotaxis. These results suggest activation of the p38 pathway may be more specific than ERK for COOH- and T3-induced VSMC chemotaxis. ..
  4. Orr A, Elzie C, Kucik D, Murphy Ullrich J. Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci. 2003;116:2917-27 pubmed
    ..Thus, TSP1/hep I stimulation of intermediate adhesion regulates the migratory phenotype of endothelial cells and fibroblasts, suggesting a role for TSP1 in remodeling responses. ..
  5. Greenaway J, Gentry P, Feige J, LaMarre J, Petrik J. Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development. Biol Reprod. 2005;72:1071-8 pubmed
    ..Regulated expression and localization of these proteins suggests that they may be involved in regulating growth and development of the follicle in a novel fashion. ..
  6. Berisha B, Schams D, Rodler D, Sinowatz F, Pfaffl M. Expression and localization of members of the thrombospondin family during final follicle maturation and corpus luteum formation and function in the bovine ovary. J Reprod Dev. 2016;62:501-510 pubmed
    ..of this study was to characterize the expression patterns and localization of the thrombospondin family members (THBS1, THBS2) and their receptors (CD36 and CD47) in bovine ovaries...
  7. Ueno A, Yamashita K, Nagata T, Tsurumi C, Miwa Y, Kitamura S, et al. cDNA cloning of bovine thrombospondin 1 and its expression in odontoblasts and predentin. Biochim Biophys Acta. 1998;1382:17-22 pubmed
    The extracellular matrix protein thrombospondin 1 (TSP1) was cloned from odontoblasts of bovine mandibular teeth which participate in dentinogenesis. The 5289 bp cDNA contains a complete open reading frame of 1170 amino acids...
  8. Congote L, Difalco M, Gibbs B. Thrombospondin 1, produced by endothelial cells under the action of erythropoietin, stimulates thymidine incorporation into erythroid cells and counteracts the inhibitory action of insulin-like growth factor binding protein 3. Cytokine. 2005;30:248-53 pubmed
    ..The production of thrombospondin 1 (TSP-1) and insulin-like growth factor binding protein 3 (IGFBP-3) is increased in cultures of human ..
  9. Maier K, Sadowitz B, Cullen S, Han X, Gahtan V. Thrombospondin-1-induced vascular smooth muscle cell migration is dependent on the hyaluronic acid receptor CD44. Am J Surg. 2009;198:664-9 pubmed publisher
    ..TSP-1 and HyA activate the EGFR. TSP-1- and HYA-induced migration share some of the same signaling pathways and the EGFR/CD44 receptors may be a common link. ..

More Information


  1. Farberov S, Meidan R. Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells. Biol Reprod. 2014;91:58 pubmed publisher
    ..THBSs and their receptors exhibited cell-specific expression: THBS1 was the predominant form in luteal endothelial cells (LEC), whereas luteinized granulosa cells (LGC) expressed ..
  2. Bhattacharyya S, Marinic T, Krukovets I, Hoppe G, Stenina O. Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose. J Biol Chem. 2008;283:5699-707 pubmed
    ..The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications. ..