Gene Symbol: STAT3
Description: signal transducer and activator of transcription 3
Alias: signal transducer and activator of transcription 3, signal transducer and activator of transcription 3 (acute-phase response factor)
Khatib H, Huang W, Mikheil D, Schutzkus V, Monson R. Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle. J Dairy Sci. 2009;92:6186-91 pubmed publisher
..The STAT1 and STAT3 genes are members of this pathway and are known to interact with each other by forming a heterodimer complex that ..
Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
Interleukin 6 (IL-6), acting via the IL-6 receptor (IL6R) and signal transducer and activator of transcription-3 (STAT3), limits neutrophil recruitment once bacterial infections are resolved...
Ni C, Hsieh H, Chao Y, Wang D. Shear flow attenuates serum-induced STAT3 activation in endothelial cells. J Biol Chem. 2003;278:19702-8 pubmed
..b>STAT3 transcription factor plays a key role in cytokine stimulation...
Legendre F, Dudhia J, Pujol J, Bogdanowicz P. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem. 2003;278:2903-12 pubmed
..interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes...
Platt D, Bartoli M, El Remessy A, Al Shabrawey M, Lemtalsi T, Fulton D, et al
. Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3. Free Radic Biol Med. 2005;39:1353-61 pubmed
..factors known to regulate VEGF expression during hypoxia and tumor angiogenesis-signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor-1 (HIF-1)...
Al Shabrawey M, Bartoli M, El Remessy A, Ma G, Matragoon S, Lemtalsi T, et al
. Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008;49:3231-8 pubmed publisher
..Prior studies have implicated oxidative stress and NADPH oxidase-mediated activation of signal transducer and activator of transcription 3 (STAT3) in diabetes-induced increases in expression of vascular endothelial growth factor (..
Song N, Gui L, Xu H, Wu S, Zan L. Identification of single nucleotide polymorphisms of the signal transducer and activator of transcription 3 gene (STAT3) associated with body measurement and carcass quality traits in beef cattle. Genet Mol Res. 2015;14:11242-9 pubmed publisher
Previous studies have shown that the signal transducer and activator of transcription 3 gene (STAT3) is involved in lipid storage and energy metabolism, suggesting that STAT3 is a potential candidate gene that affects body measurement and ..
Rovani M, Ilha G, Gasperin B, NÃ³brega J, Siddappa D, Glanzner W, et al
. Prostaglandin F2Î±-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle. Mol Reprod Dev. 2017;84:486-494 pubmed publisher
..b>Signal transducer and activator of transcription 3 (STAT3) was activated in granulosa cells during follicle atresia, whereas AKT is immediately ..