Gene Symbol: STAT1
Description: signal transducer and activator of transcription 1, 91kDa
Alias: signal transducer and activator of transcription 1-alpha/beta, transcription factor ISGF-3
Cobanoglu O, Zaitoun I, Chang Y, Shook G, Khatib H. Effects of the signal transducer and activator of transcription 1 (STAT1) gene on milk production traits in Holstein dairy cattle. J Dairy Sci. 2006;89:4433-7 pubmed
..Signal transducer and activator of transcription 1 (STAT1) was chosen because of its involvement in the development of the mammary gland...
Douglas S, Bunn S. Interferon-alpha signalling in bovine adrenal chromaffin cells: involvement of signal-transducer and activator of transcription 1 and 2, extracellular signal-regulated protein kinases 1/2 and serine 31 phosphorylation of tyrosine hydroxylase. J Neuroendocrinol. 2009;21:200-7 pubmed publisher
..Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2...
Legendre F, Dudhia J, Pujol J, Bogdanowicz P. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem. 2003;278:2903-12 pubmed
..that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes...
Khatib H, Huang W, Mikheil D, Schutzkus V, Monson R. Effects of signal transducer and activator of transcription (STAT) genes STAT1 and STAT3 genotypic combinations on fertilization and embryonic survival rates in Holstein cattle. J Dairy Sci. 2009;92:6186-91 pubmed publisher
..The STAT1 and STAT3 genes are members of this pathway and are known to interact with each other by forming a heterodimer ..
Vitorino Carvalho A, Eozenou C, Healey G, Forde N, Reinaud P, Chebrout M, et al
. Analysis of STAT1 expression and biological activity reveals interferon-tau-dependent STAT1-regulated SOCS genes in the bovine endometrium. Reprod Fertil Dev. 2016;28:459-74 pubmed publisher
..In cattle, microarray analyses identified STAT1 as a differentially expressed gene in the endometrium during the peri-implantation period...