STAR

Summary

Gene Symbol: STAR
Description: steroidogenic acute regulatory protein
Alias: steroidogenic acute regulatory protein, mitochondrial, START domain-containing protein 1, stARD1, steroidogenic acute regulator
Species: cow

Top Publications

  1. Hartung S, Rust W, Balvers M, Ivell R. Molecular cloning and in vivo expression of the bovine steroidogenic acute regulatory protein. Biochem Biophys Res Commun. 1995;215:646-53 pubmed
    ..One of these clones encoded the bovine homologue of the Steroidogenic Acute Regulatory protein (StAR). The bovine StAR gene is transcribed as 3kb and 1...
  2. Yamashita H, Murayama C, Takasugi R, Miyamoto A, Shimizu T. BMP-4 suppresses progesterone production by inhibiting histone H3 acetylation of StAR in bovine granulosa cells in vitro. Mol Cell Biochem. 2011;348:183-90 pubmed publisher
    ..progesterone secretion in granulosa cells and suppressed the expression of steroidogenic acute regulatory protein (StAR) at the mRNA and protein levels, whereas BMP-4 did not affect the proliferation of granulosa cells...
  3. Rust W, Stedronsky K, Tillmann G, Morley S, Walther N, Ivell R. The role of SF-1/Ad4BP in the control of the bovine gene for the steroidogenic acute regulatory (StAR) protein. J Mol Endocrinol. 1998;21:189-200 pubmed
    The bovine gene for the steroidogenic acute regulatory protein (StAR) was cloned and sequenced, including 2 kb of the upstream control region of the gene...
  4. Yamazaki T, Matsuoka C, Gendou M, Izumi S, Zhao D, Artemenko I, et al. Mitochondrial processing of bovine adrenal steroidogenic acute regulatory protein. Biochim Biophys Acta. 2006;1764:1561-7 pubmed
    Steroidogenic acute regulatory (StAR) protein is an important regulatory protein in steroidogenesis and rapidly undergoes proteolysis after import into the mitochondria...
  5. Rincon Garriz J, Suarez C, Capponi A. c-Fos mediates angiotensin II-induced aldosterone production and protein synthesis in bovine adrenal glomerulosa cells. Endocrinology. 2009;150:1294-302 pubmed publisher
    ..c-Fos and c-Jun, have been identified, among others, in the promoter of the steroidogenic acute regulatory (StAR) protein gene, whose expression is acutely regulated by activators of aldosterone production...
  6. Murayama C, Miyazaki H, Miyamoto A, Shimizu T. Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. Mol Cell Endocrinol. 2012;350:1-9 pubmed publisher
    ..Low LH enhanced production of A4 and P4, and expressions of CYP17 and StAR mRNA in theca cells without pre-treatment with high LH...
  7. Herzog K, Str ve K, Kastelic J, Piechotta M, Ulbrich S, Pfarrer C, et al. Escherichia coli lipopolysaccharide administration transiently suppresses luteal structure and function in diestrous cows. Reproduction. 2012;144:467-76 pubmed publisher
    ..05), whereas those encoding StAR were decreased (P?0.05) in cattle given LPS vs saline...
  8. Olala L, Choudhary V, Johnson M, Bollag W. Angiotensin II-induced protein kinase D activates the ATF/CREB family of transcription factors and promotes StAR mRNA expression. Endocrinology. 2014;155:2524-33 pubmed publisher
    ..is the rate-limiting step in acute aldosterone production and is mediated by the steroidogenic acute regulatory (StAR) protein...
  9. Hartigan J, Green E, Mortensen R, Menachery A, Williams G, Orme Johnson N. Comparison of protein phosphorylation patterns produced in adrenal cells by activation of cAMP-dependent protein kinase and Ca-dependent protein kinase. J Steroid Biochem Mol Biol. 1995;53:95-101 pubmed
    ..Further, the fact, that pp37 is phosphorylated only when the rate of steroidogenesis is enhanced, reaffirms its potential involvement in the signaling pathway that causes stimulation of steroid hormone biosynthesis. ..