SPP1

Summary

Gene Symbol: SPP1
Description: secreted phosphoprotein 1
Alias: SPP-1, bone sialoprotein 1, bone sialoprotein I, early T-lymphocyte activation 1, osteopontin, osteopontin-K, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Species: cow

Top Publications

  1. ncbi Fine-mapping milk production quantitative trait loci on BTA6: analysis of the bovine osteopontin gene
    Robert D Schnabel
    Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 102:6896-901. 2005
  2. ncbi Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification
    Fawzy A Saad
    Laboratory for Study of Skeletal Disorders and Rehabilitation, Department of Orthopaedic Surgery, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Cell Biochem 103:852-6. 2008
  3. ncbi Binding patterns of bovine seminal plasma proteins A1/A2, 30 kDa and osteopontin on ejaculated sperm before and after incubation with isthmic and ampullary oviductal fluid
    Carlos Eduardo A Souza
    Department of Animal Science, Federal University of Ceara, Brazil
    Anim Reprod Sci 105:72-89. 2008
  4. ncbi Osteopontin immunoreactivity in the ileum and ileocecal lymph node of dairy cows naturally infected with Mycobacterium avium subsp. paratuberculosis
    E L Karcher
    Department of Animal Science, Iowa State University, Ames, IA 50010, USA
    Vet Immunol Immunopathol 126:142-8. 2008
  5. ncbi Osteopontin: a novel cytokine involved in the regulation of Mycobacterium avium subspecies paratuberculosis infection in periparturient dairy cattle
    E L Karcher
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    J Dairy Sci 91:3079-91. 2008
  6. ncbi Isolation and characterization of a cDNA for osteopontin-k: a kidney cell adhesion molecule with high homology to osteopontins
    J F Crivello
    Department of Physiology and Neurobiology, University of Connecticut, Storrs
    J Bone Miner Res 7:693-9. 1992
  7. ncbi Role of phosphate groups in inhibition of calcium oxalate crystal growth by osteopontin
    Graeme K Hunter
    School of Dentistry and CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 189:44-50. 2009
  8. ncbi A functional genomics approach to evaluate candidate genes located in a QTL interval for milk production traits on BTA6
    P A Sheehy
    REPROGEN and Cooperative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Anim Genet 40:492-8. 2009
  9. ncbi Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin
    Aaron P Yamniuk
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
    Mol Immunol 46:2395-402. 2009
  10. ncbi Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration
    David W Erikson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 81:814-25. 2009

Scientific Experts

  • Hasan Khatib
  • P A Sheehy
  • Erdjan Salih
  • Robert D Schnabel
  • Fawzy A Saad
  • Graeme K Hunter
  • Karin Alain
  • E L Karcher
  • Barbro Ek-Rylander
  • David W Erikson
  • Aaron P Yamniuk
  • D C Beitz
  • J R Stabel
  • Carlos Eduardo A Souza
  • S N White
  • Miri Cohen Zinder
  • Nevenka Mestrović
  • S Leonard
  • Séverine A Degrelle
  • Goran Andersson
  • Hans Burling
  • Robert C Burghardt
  • Kayla J Bayless
  • Hans J Vogel
  • Greg A Johnson
  • Elisa Monaco
  • C S Johnson
  • Gary J Killian
  • J P Bannantine
  • D O Bayles
  • Arlindo A Moura
  • M F Allan
  • T P L Smith
  • J W Keele
  • W M Snelling
  • E Casas
  • M Koohmaraie
  • S D Shackelford
  • T L Wheeler
  • E S Sørensen
  • Jun-Heon Lee
  • Isabelle Hue
  • Jun Heon Lee
  • Pierre Abad
  • Juan J Loor
  • Mark R Band
  • Annelie Everts-van der Wind
  • Christophe Richard
  • Onivaldo Randig
  • Philippe Castagnone-Sereno
  • Jean Paul Renard
  • Annelie Everts van der Wind
  • Joel I Weller
  • Miri Cohen-Zinder
  • Cédric Cabau
  • Jean-Paul Renard
  • A G Hernandez
  • Moshe Shani
  • Denis M Larkin
  • Francois Piumi
  • Miroslav Plohl
  • C Maltecca
  • James K Drackley
  • Eyal Seroussi
  • Pierrette Reinaud
  • Evelyne Campion
  • Micha Ron
  • Harris A Lewin
  • V Schutzkus
  • Y M Chang
  • T E Petersen
  • P Højrup
  • J F Crivello
  • J M Kerr
  • E Delvin
  • L W Fisher
  • J D Termine
  • M F Young

Detail Information

Publications23

  1. ncbi Fine-mapping milk production quantitative trait loci on BTA6: analysis of the bovine osteopontin gene
    Robert D Schnabel
    Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 102:6896-901. 2005
    ..Next, we sequenced a 12.3-kb region harboring Osteopontin, a positional candidate for the statistically most significant of the identified QTL...
  2. ncbi Identification of osteopontin phosphorylation sites involved in bone remodeling and inhibition of pathological calcification
    Fawzy A Saad
    Laboratory for Study of Skeletal Disorders and Rehabilitation, Department of Orthopaedic Surgery, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Cell Biochem 103:852-6. 2008
    b>Osteopontin is a noncollagenous, phosphorylated extracellular glycoprotein, expressed in mineralized and nonmineralized tissues, organs and body fluids...
  3. ncbi Binding patterns of bovine seminal plasma proteins A1/A2, 30 kDa and osteopontin on ejaculated sperm before and after incubation with isthmic and ampullary oviductal fluid
    Carlos Eduardo A Souza
    Department of Animal Science, Federal University of Ceara, Brazil
    Anim Reprod Sci 105:72-89. 2008
    ..have reported empirical associations between bovine seminal plasma protein(s) (BSP) A1/A2 and 30 kDa and osteopontin (OPN) in accessory sex gland fluid and bull fertility...
  4. ncbi Osteopontin immunoreactivity in the ileum and ileocecal lymph node of dairy cows naturally infected with Mycobacterium avium subsp. paratuberculosis
    E L Karcher
    Department of Animal Science, Iowa State University, Ames, IA 50010, USA
    Vet Immunol Immunopathol 126:142-8. 2008
    b>Osteopontin (Opn), a highly acidic glycoprotein, promotes cellular adhesion and recruitment and has been shown to be upregulated in the granulomas of mycobacterial infections. Johne's disease, caused by Mycobacterium avium subsp...
  5. ncbi Osteopontin: a novel cytokine involved in the regulation of Mycobacterium avium subspecies paratuberculosis infection in periparturient dairy cattle
    E L Karcher
    Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA
    J Dairy Sci 91:3079-91. 2008
    b>Osteopontin (Opn), an important mediator of the cell-mediated immune response, enhances the host immune response against mycobacterial infections. Infections caused by Mycobacterium avium ssp...
  6. ncbi Isolation and characterization of a cDNA for osteopontin-k: a kidney cell adhesion molecule with high homology to osteopontins
    J F Crivello
    Department of Physiology and Neurobiology, University of Connecticut, Storrs
    J Bone Miner Res 7:693-9. 1992
    ..The peptide (osteopontin-k) had a potential glycosylation site (Asn-X-Ser/Thr), a GRGDS receptor binding region, a high level of ..
  7. ncbi Role of phosphate groups in inhibition of calcium oxalate crystal growth by osteopontin
    Graeme K Hunter
    School of Dentistry and CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 189:44-50. 2009
    b>Osteopontin (OPN) inhibits the growth of calcium oxalate monohydrate (COM) and other crystal phases in a phosphorylation-dependent manner...
  8. ncbi A functional genomics approach to evaluate candidate genes located in a QTL interval for milk production traits on BTA6
    P A Sheehy
    REPROGEN and Cooperative Research Centre for Innovative Dairy Products, Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia
    Anim Genet 40:492-8. 2009
    ..These data suggest that the gene product of SPP1 (also known as osteopontin) has a significant role in the modulation of milk protein gene expression...
  9. ncbi Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin
    Aaron P Yamniuk
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
    Mol Immunol 46:2395-402. 2009
    The immunoregulatory proteins osteopontin (OPN) and lactoferrin (LF) are both highly abundant in milk, with a conserved ratio between different mammalian species, suggesting that the role of each protein in infant development may be ..
  10. ncbi Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration
    David W Erikson
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 81:814-25. 2009
    ..Secreted phosphoprotein 1 (SPP1, osteopontin) is induced just before implantation and is present at the conceptus-maternal interface in mammals...
  11. ncbi Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis
    Karin Alain
    Dairy and Swine Research and Development Centre, Agriculture and Agri Food Canada, Sherbrooke, Quebec, J1M 1Z3, Canada
    BMC Genomics 10:444. 2009
    ....
  12. ncbi The association of bovine PPARGC1A and OPN genes with milk composition in two independent Holstein cattle populations
    H Khatib
    Department of Dairy Science, University of Wisconsin, Madison 53706, USA
    J Dairy Sci 90:2966-70. 2007
    ..b>Osteopontin (OPN) and peroxisome proliferator activated receptor gamma coactivator 1 alpha (PPARGC1A) are located in the ..
  13. ncbi Evaluation in beef cattle of six deoxyribonucleic acid markers developed for dairy traits reveals an osteopontin polymorphism associated with postweaning growth
    S N White
    USDA, ARS, US Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 85:1-10. 2007
    ..with milk yield or composition, including polymorphisms in secreted phosphoprotein 1 (SPP1; also called osteopontin), growth hormone receptor (GHR), casein S1 (CSN1S1), diacylglycerol O-acyltransferase 1 (DGAT1), peroxisome ..
  14. ncbi The cDNA cloning and RNA distribution of bovine osteopontin
    J M Kerr
    Bone Research Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
    Gene 108:237-43. 1991
    We have isolated and sequenced the bovine cDNA (OPN) counterpart of osteopontin. The cDNA is 1356 nucleotides (nt) in length with an open reading frame of 834 nt, encoding a 278-amino acid (aa) protein...
  15. ncbi Purification and characterization of three proteins isolated from the proteose peptone fraction of bovine milk
    E S Sørensen
    Department of Molecular Biology, University of Aarhus, Denmark
    J Dairy Res 60:189-97. 1993
    ..The 60 kDa protein was found to be bovine osteopontin, a very highly phosphorylated protein with an Arg-Gly-Asp sequence which mediates cell attachment.
  16. ncbi Posttranslational modifications of bovine osteopontin: identification of twenty-eight phosphorylation and three O-glycosylation sites
    E S Sørensen
    Protein Chemistry Laboratory, University of Aarhus, Denmark
    Protein Sci 4:2040-9. 1995
    b>Osteopontin (OPN) is a multiphosphorylated glycoprotein found in bone and other normal and malignant tissues, as well as in the physiological fluids urine and milk...
  17. ncbi Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases
    E Salih
    Department of Orthopaedic Surgery, Harvard Medical School and The Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 271:16897-905. 1996
    The large number of covalently bound phosphates on the extracellular phosphoproteins osteopontin (OPN) and bone sialoprotein (BSP) have been implicated in biological functions such as mineral deposition and osteoclast binding...
  18. ncbi Complete topographical distribution of both the in vivo and in vitro phosphorylation sites of bone sialoprotein and their biological implications
    Erdjan Salih
    Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Harvard Medical School and Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 279:19808-15. 2004
    ..Overall, 7 in vitro and 11 in vivo phosphorylation sites were identified unequivocally, with natural variation in the quantitative extent of phosphorylation at each in vivo phosphorylation site...
  19. ncbi Conserved and variable domains in satellite DNAs of mitotic parthenogenetic root-knot nematode species
    Nevenka Mestrović
    Ruder Boskovic Institute, Zagreb, Croatia
    Gene 362:44-50. 2005
    ..javanica and M. arenaria and highly homogenized divergent positions in comparison with the MPA1 indicate similar sequence dynamics in mitotic parthenogenetic taxa to that observed in amphimictic species...
  20. ncbi Effects of the osteopontin gene variants on milk production traits in dairy cattle
    S Leonard
    Department of Dairy Science, University of Wisconsin Madison, Madison 53706, USA
    J Dairy Sci 88:4083-6. 2005
    b>Osteopontin (OPN) is a highly phosphorylated glycoprotein whose gene has been cloned and sequenced in different species...
  21. ncbi Molecular evidence for a critical period in mural trophoblast development in bovine blastocysts
    Séverine A Degrelle
    UMR INRA ENVA CNRS Biologie du Développement et de la Reproduction, 78352 Jouy en Josas Cedex, France
    Dev Biol 288:448-60. 2005
    ..Altogether, these results tended to show that early elongation is a critical transition in bovine trophoblast development...
  22. ncbi Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase
    Barbro Ek-Rylander
    Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Karolinska University Hospital, SE 141 86 Huddinge, Sweden
    Exp Cell Res 316:443-51. 2010
    b>Osteopontin (OPN) is a multifunctional protein implicated in cellular adhesion and migration. Phosphorylation has emerged as a post-translational modification important for certain biological activities of OPN...
  23. ncbi Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle
    Miri Cohen Zinder
    Institute of Animal Sciences, Agricultural Research Organization, Bet Dagan 50250, Israel
    Genome Res 15:936-44. 2005
    ..variation in this region and identified common haplotypes spanning five polymorphic sites in the genes IBSP, SPP1, PKD2, and ABCG2 for two sires heterozygous for this QTL...