sodium calcium exchanger


Gene Symbol: sodium calcium exchanger
Description: solute carrier family 8 member A1
Alias: NCX1, sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, sodium-calcium exchanger, solute carrier family 8, member 1
Species: cow

Top Publications

  1. Bossuyt J, Taylor B, James Kracke M, Hale C. The cardiac sodium-calcium exchanger associates with caveolin-3. Ann N Y Acad Sci. 2002;976:197-204 pubmed
    The cardiac Na/Ca exchanger's (NCX1) role in calcium homeostasis during myocardial contractility makes it a possible target of signaling factors regulating inotropy...
  2. Beaugé L, Asteggiano C, Berberián G. Regulation of phosphatidylinositol-4,5-biphosphate bound to the bovine cardiac Na+/Ca2+ exchanger. Ann N Y Acad Sci. 2002;976:288-99 pubmed
    ..vesicles phosphatidylinositol-4,5-biphosphate (PtdIns-4,5-P(2)) binds strongly to the Na(+)/Ca(2+) exchanger (NCX1)...
  3. Chakraborti S, Mandal A, Das S, Chakraborti T. Inhibition of Na+/Ca2+ exchanger by peroxynitrite in microsomes of pulmonary smooth muscle: role of matrix metalloproteinase-2. Biochim Biophys Acta. 2004;1671:70-8 pubmed
  4. Hirota S, Pertens E, Janssen L. The reverse mode of the Na(+)/Ca(2+) exchanger provides a source of Ca(2+) for store refilling following agonist-induced Ca(2+) mobilization. Am J Physiol Lung Cell Mol Physiol. 2007;292:L438-47 pubmed
    ..Furthermore, KB-R7943 abolished successive caffeine-induced Ca(2+) transients in single ASM cells. Together, these data suggest a role for the reverse mode of the NCX in refilling the SR in ASM following Ca(2+) mobilization. ..
  5. Kar P, Chakraborti T, Samanta K, Chakraborti S. mu-Calpain mediated cleavage of the Na+/Ca2+ exchanger in isolated mitochondria under A23187 induced Ca2+ stimulation. Arch Biochem Biophys. 2009;482:66-76 pubmed publisher
    ..This cleavage of NCX may be interpreted as the main cause of Ca(2+) overload and could lay a key role in the activation of apoptotic process in pulmonary smooth muscle. ..
  6. Aceto J, Condrescu M, Kroupis C, Nelson H, Nelson N, Nicoll D, et al. Cloning and expression of the bovine cardiac sodium-calcium exchanger. Arch Biochem Biophys. 1992;298:553-60 pubmed
    ..The results suggest that alternate splicing mechanisms may be involved in processing mRNA for the bovine cardiac exchanger. ..
  7. Durkin J, Ahrens D, Pan Y, Reeves J. Purification and amino-terminal sequence of the bovine cardiac sodium-calcium exchanger: evidence for the presence of a signal sequence. Arch Biochem Biophys. 1991;290:369-75 pubmed
    ..The characteristics of the sequences flanking the first putative transmembrane segment of the mature exchanger suggest that the signal sequence is necessary to ensure the correct topological orientation of the exchanger in the membrane. ..
  8. Reid D, Friedel U, Molday R, Cook N. Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane. Biochemistry. 1990;29:1601-7 pubmed
  9. Shaikh S, Samanta K, Kar P, Roy S, Chakraborti T, Chakraborti S. m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle. Mol Cell Biochem. 2010;341:167-80 pubmed publisher
    ..We have also identified Na(+)/Ca(2+) exchanger-1 (NCX1) in the caveolae vesicles...

More Information


  1. Yang Y, Fann M, Chang W, Tai L, Jiang J, Kao L. Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions. J Biol Chem. 2010;285:28275-85 pubmed publisher
    ..Recent evidence has shown that proteins, including kinases and phosphatases, associate with NCX1IL to form a NCX1 macromolecular complex...
  2. Forcato D, Posada V, Beaugé L, Berberián G. Optimal metabolic regulation of the mammalian heart Na(+)/Ca(2+) exchanger requires a spacial arrangements with a PtdIns(4)-5kinase. Biochem Biophys Res Commun. 2010;402:147-52 pubmed publisher
    ..PCMBS) and n-ethylmaleimide (NEM) fully inhibited MgATP up-regulation of the Na(+)/Ca(2+) exchanger (NCX1) and abolished the MgATP-dependent PtdIns-4,5P2 increase in the NCX1-PtdIns-4,5P2 complex; in addition, these ..