SCD

Summary

Gene Symbol: SCD
Description: stearoyl-CoA desaturase (delta-9-desaturase)
Alias: SCD1, acyl-CoA desaturase, delta(9)-desaturase, fatty acid desaturase, stearoyl-coenzyme A desaturase
Species: cow
Products:     SCD

Top Publications

  1. Keating A, Stanton C, Murphy J, Smith T, Ross R, Cairns M. Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows. Mamm Genome. 2005;16:184-93 pubmed
    ..of dietary polyunsaturated fatty acids (PUFA) in the rumen, and by the action of mammary Stearoyl-CoA desaturase (Scd)...
  2. Mele M, Conte G, Castiglioni B, Chessa S, Macciotta N, Serra A, et al. Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins. J Dairy Sci. 2007;90:4458-65 pubmed
    ..Stearoyl-CoA desaturase (SCD) is a key enzyme in mammary lipid metabolism because it is able to add a double bond in the cis delta9-position in ..
  3. Schennink A, Heck J, Bovenhuis H, Visker M, van Valenberg H, van Arendonk J. Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1). J Dairy Sci. 2008;91:2135-43 pubmed publisher
    ..23 +/- 0.07 for conjugated linoleic acid (CLA) index to 0.46 +/- 0.09 for C16 index. We genotyped the cows for the SCD1 A293V and DGAT1 K232A polymorphisms, which are known to alter milk fatty acid composition...
  4. Ohsaki H, Sawa T, Sasazaki S, Kano K, Taniguchi M, Mukai F, et al. Stearoyl-CoA desaturase mRNA expression during bovine adipocyte differentiation in primary culture derived from Japanese Black and Holstein cattle. Comp Biochem Physiol A Mol Integr Physiol. 2007;148:629-34 pubmed
    Stearoyl-CoA desaturase (SCD) catalyzes the synthesis of monounsaturated fatty acids (MUFAs). In cattle, the MUFAs are related to softness and flavor of meat...
  5. Invernizzi G, Thering B, McGuire M, Savoini G, Loor J. Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. Funct Integr Genomics. 2010;10:561-75 pubmed publisher
    ..Expression of THRSP decreased by day 7 with both diets and returned to basal levels by day 21. SCD expression increased linearly through 7 days and remained elevated with both diets, a likely mechanism to ensure ..
  6. Choi S, Wickersham T, Wu G, Gilmore L, Edwards H, Park S, et al. Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid. Amino Acids. 2014;46:353-66 pubmed publisher
    ..we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c...
  7. Soyeurt H, Dehareng F, Mayeres P, Bertozzi C, Gengler N. Variation of Delta 9-desaturase activity in dairy cattle. J Dairy Sci. 2008;91:3211-24 pubmed publisher
    ..The positive genetic correlations observed between %MONO and the ratios of C14:1 cis-9 to C14:0 (0.72), C16:1 cis-9 to C16:0 (0.62), and C18:1 cis to C18:0 (0.97) showed that %MONO is linked to the Delta(9)-desaturase activity. ..
  8. Milanesi E, Nicoloso L, Crepaldi P. Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds. J Anim Breed Genet. 2008;125:63-7 pubmed publisher
    Stearoyl CoA desaturase (SCD) is the key enzyme involved in the endogenous synthesis of conjugated linoleic acid (CLA) in ruminants...
  9. Moioli B, Contarini G, Avalli A, Catillo G, Orrù L, De Matteis G, et al. Short communication: Effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk. J Dairy Sci. 2007;90:3553-8 pubmed
    The effect of the stearoyl-CoA desaturase (SCD) gene on milk fatty acid composition was tested. Cows of 3 breeds of northern Italy, Piedmontese, Valdostana, and Jersey, were genotyped at exon 5 of the SCD gene...
  10. Duchemin S, Bovenhuis H, Stoop W, Bouwman A, van Arendonk J, Visker M. Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions. J Dairy Sci. 2013;96:592-604 pubmed publisher
    ..effects of acyl-coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) K232A, and stearoyl-coenzyme A desaturase 1 (SCD1) A293V polymorphisms for milk fat composition in winter and summer, and tested for genotype by season interactions ..

Detail Information

Publications36

  1. Keating A, Stanton C, Murphy J, Smith T, Ross R, Cairns M. Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows. Mamm Genome. 2005;16:184-93 pubmed
    ..of dietary polyunsaturated fatty acids (PUFA) in the rumen, and by the action of mammary Stearoyl-CoA desaturase (Scd)...
  2. Mele M, Conte G, Castiglioni B, Chessa S, Macciotta N, Serra A, et al. Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins. J Dairy Sci. 2007;90:4458-65 pubmed
    ..Stearoyl-CoA desaturase (SCD) is a key enzyme in mammary lipid metabolism because it is able to add a double bond in the cis delta9-position in ..
  3. Schennink A, Heck J, Bovenhuis H, Visker M, van Valenberg H, van Arendonk J. Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1). J Dairy Sci. 2008;91:2135-43 pubmed publisher
    ..23 +/- 0.07 for conjugated linoleic acid (CLA) index to 0.46 +/- 0.09 for C16 index. We genotyped the cows for the SCD1 A293V and DGAT1 K232A polymorphisms, which are known to alter milk fatty acid composition...
  4. Ohsaki H, Sawa T, Sasazaki S, Kano K, Taniguchi M, Mukai F, et al. Stearoyl-CoA desaturase mRNA expression during bovine adipocyte differentiation in primary culture derived from Japanese Black and Holstein cattle. Comp Biochem Physiol A Mol Integr Physiol. 2007;148:629-34 pubmed
    Stearoyl-CoA desaturase (SCD) catalyzes the synthesis of monounsaturated fatty acids (MUFAs). In cattle, the MUFAs are related to softness and flavor of meat...
  5. Invernizzi G, Thering B, McGuire M, Savoini G, Loor J. Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements. Funct Integr Genomics. 2010;10:561-75 pubmed publisher
    ..Expression of THRSP decreased by day 7 with both diets and returned to basal levels by day 21. SCD expression increased linearly through 7 days and remained elevated with both diets, a likely mechanism to ensure ..
  6. Choi S, Wickersham T, Wu G, Gilmore L, Edwards H, Park S, et al. Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid. Amino Acids. 2014;46:353-66 pubmed publisher
    ..we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c...
  7. Soyeurt H, Dehareng F, Mayeres P, Bertozzi C, Gengler N. Variation of Delta 9-desaturase activity in dairy cattle. J Dairy Sci. 2008;91:3211-24 pubmed publisher
    ..The positive genetic correlations observed between %MONO and the ratios of C14:1 cis-9 to C14:0 (0.72), C16:1 cis-9 to C16:0 (0.62), and C18:1 cis to C18:0 (0.97) showed that %MONO is linked to the Delta(9)-desaturase activity. ..
  8. Milanesi E, Nicoloso L, Crepaldi P. Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds. J Anim Breed Genet. 2008;125:63-7 pubmed publisher
    Stearoyl CoA desaturase (SCD) is the key enzyme involved in the endogenous synthesis of conjugated linoleic acid (CLA) in ruminants...
  9. Moioli B, Contarini G, Avalli A, Catillo G, Orrù L, De Matteis G, et al. Short communication: Effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk. J Dairy Sci. 2007;90:3553-8 pubmed
    The effect of the stearoyl-CoA desaturase (SCD) gene on milk fatty acid composition was tested. Cows of 3 breeds of northern Italy, Piedmontese, Valdostana, and Jersey, were genotyped at exon 5 of the SCD gene...
  10. Duchemin S, Bovenhuis H, Stoop W, Bouwman A, van Arendonk J, Visker M. Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions. J Dairy Sci. 2013;96:592-604 pubmed publisher
    ..effects of acyl-coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) K232A, and stearoyl-coenzyme A desaturase 1 (SCD1) A293V polymorphisms for milk fat composition in winter and summer, and tested for genotype by season interactions ..
  11. Lengi A, Corl B. Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. Lipids. 2007;42:499-508 pubmed
    ..time a second SCD isoform in cattle, which appears to be an ortholog of human SCD5 rather than a homolog of bovine SCD1 or any of the described murine SCD isoforms...
  12. Kgwatalala P, Ibeagha Awemu E, Hayes J, Zhao X. Stearoyl-CoA desaturase 1 3'UTR SNPs and their influence on milk fatty acid composition of Canadian Holstein cows. J Anim Breed Genet. 2009;126:394-403 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) catalyses the synthesis of conjugated linoleic acid (CLA) and mono-unsaturated fatty acids (MUFA) in the mammary gland of ruminant animals...
  13. Li C, Sun D, Zhang S, Liu L, Alim M, Zhang Q. A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population. Anim Genet. 2016;47:483-90 pubmed publisher
    ..8-Mb region (20.3-22.1 Mb) on chromosome 26 underlying the SCD gene and were highly significantly associated with C14:1 or C14 index...
  14. Narukami T, Sasazaki S, Oyama K, Nogi T, Taniguchi M, Mannen H. Effect of DNA polymorphisms related to fatty acid composition in adipose tissue of Holstein cattle. Anim Sci J. 2011;82:406-11 pubmed publisher
    ..we investigated the effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) on fatty acid composition in intramuscular ..
  15. Brooks M, Choi C, Lunt D, Kawachi H, Smith S. Subcutaneous and intramuscular adipose tissue stearoyl-coenzyme A desaturase gene expression and fatty acid composition in calf- and yearling-fed Angus steers. J Anim Sci. 2011;89:2556-70 pubmed publisher
    We proposed that stearoyl-CoA desaturase (SCD) activity dictates fatty acid composition of adipose tissue and muscle in beef cattle, regardless of ruminal or hepatic fatty acid hydrogenation or desaturation...
  16. Yokota S, Sugita H, Ardiyanti A, Shoji N, Nakajima H, Hosono M, et al. Contributions of FASN and SCD gene polymorphisms on fatty acid composition in muscle from Japanese Black cattle. Anim Genet. 2012;43:790-2 pubmed publisher
    The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition...
  17. Li C, Aldai N, Vinsky M, Dugan M, McAllister T. Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers. Anim Genet. 2012;43:93-7 pubmed publisher
    ..coding single nucleotide polymorphisms (SNPs) of bovine stearoyl-CoA desaturase (delta-9-desaturase) (SCD) (c...
  18. Costa A, Silva M, Alfaia C, Pires V, Fontes C, Bessa R, et al. Genetic background and diet impact beef fatty acid composition and stearoyl-CoA desaturase mRNA expression. Lipids. 2013;48:369-81 pubmed publisher
    ..on lipid metabolism in the muscle, which may be, at least partially, modulated by the stearoyl-CoA desaturase (SCD) gene expression levels...
  19. Chung M, Ha S, Jeong S, Bok J, Cho K, Baik M, et al. Cloning and characterization of bovine stearoyl CoA desaturasel cDNA from adipose tissues. Biosci Biotechnol Biochem. 2000;64:1526-30 pubmed
    ..and more than 88% similarities to other mammalian SCD1s, indicating that the clones are the cDNAs for the bovine SCD1. The transcript size of the bovine SCD1 was about 4...
  20. Herdmann A, MARTIN J, Nuernberg G, Dannenberger D, Nuernberg K. Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing. J Agric Food Chem. 2010;58:8314-21 pubmed publisher
    ..acid (ALA) versus linoleic acid (LA) on meat quality, fatty acid composition, and stearoyl-CoA desaturase (SCD) activity in longissimus muscle (MLD) and subcutaneous adipose tissue (SAT) of German Holstein bulls and the ..
  21. Barton L, Kott T, Bures D, Rehak D, Zahrádková R, Kottová B. The polymorphisms of stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes and their association with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls. Meat Sci. 2010;85:15-20 pubmed publisher
    The previously reported genetic polymorphisms of the stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes were investigated in Fleckvieh bulls using the PCR-RFLP and AS-PCR methods, respectively...
  22. Macciotta N, Mele M, Conte G, Serra A, Cassandro M, Dal Zotto R, et al. Association between a polymorphism at the stearoyl CoA desaturase locus and milk production traits in Italian Holsteins. J Dairy Sci. 2008;91:3184-9 pubmed publisher
    Associations between stearoyl-CoA desaturase (SCD) gene polymorphisms and milk production traits (milk, fat, and protein yields, fat and protein contents, somatic cell score) were investigated on a sample of 701 lactations of 313 Italian ..
  23. Conte G, Mele M, Chessa S, Castiglioni B, Serra A, Pagnacco G, et al. Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. J Dairy Sci. 2010;93:753-63 pubmed publisher
    Several lipogenic genes have been shown to have effects on lipid metabolism: stearoyl CoA desaturase 1 (SCD1) catalyzes the desaturation of several fatty acids (FA) in the cis-Delta(9) position in mammary glands of ruminant animals, ..
  24. di Martino O, Troiano A, Addi L, Guarino A, Calabrò S, Tudisco R, et al. Regulation of Stearoyl Coenzyme A Desaturase 1 Gene Promoter in Bovine Mammary Cells. Anim Biotechnol. 2015;26:251-9 pubmed publisher
    Stearoyl-Coenzyme A desaturase 1 (SCD1) belongs to the fatty acid family of desaturases...
  25. Carvajal A, Huircan P, Dezamour J, Subiabre I, Kerr B, Morales R, et al. Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation. Genet Mol Res. 2016;15: pubmed publisher
    ..Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated...
  26. Barto L, BURE D, Kott T, Reh k D. Effect of sex and age on bovine muscle and adipose fatty acid composition and stearoyl-CoA desaturase mRNA expression. Meat Sci. 2011;89:444-50 pubmed publisher
    ..The expression of the stearoyl-CoA desaturase gene was higher in the adipose tissue of heifers compared to bulls, and its variation partly contributed to sex- and age-differences in the FA composition of bovine adipose tissue...
  27. Demeter R, Schopen G, Lansink A, Meuwissen M, van Arendonk J. Effects of milk fat composition, DGAT1, and SCD1 on fertility traits in Dutch Holstein cattle. J Dairy Sci. 2009;92:5720-9 pubmed publisher
    ..this study were to examine 1) the effect of milk fat composition, and 2) the effect of polymorphisms of DGAT1 and SCD1 genes on female fertility in commercial Dutch Holstein-Friesian cattle...
  28. Alim M, Fan Y, Wu X, Xie Y, Zhang S, Sun D, et al. Genetic effects of stearoyl-coenzyme A desaturase (SCD) polymorphism on milk production traits in the Chinese dairy population. Mol Biol Rep. 2012;39:8733-40 pubmed publisher
    Stearoyl-CoA desaturase (SCD) is a multifunctional complex enzyme important in the cellular biosynthesis of fatty acids. The present study was to investigate the association of the SCD gene with milk production traits in dairy cattle...
  29. Kgwatalala P, Ibeagha Awemu E, Hayes J, Zhao X. Single nucleotide polymorphisms in the open reading frame of the stearoyl-CoA desaturase gene and resulting genetic variants in Canadian Holstein and Jersey cows. DNA Seq. 2007;18:357-62 pubmed
    Stearoyl-CoA desaturase (SCD) catalyzes the synthesis of conjugated linoleic acid (CLA) and mono-unsaturated fatty acids (MUFA) from their saturated counterparts in the mammary gland and adipose tissue of ruminant animals...
  30. Keating A, Kennelly J, Zhao F. Characterization and regulation of the bovine stearoyl-CoA desaturase gene promoter. Biochem Biophys Res Commun. 2006;344:233-40 pubmed
    The bovine stearoyl-CoA desaturase (Scd) gene plays an important role in the bovine mammary gland where substrates such as stearic and vaccenic acids are converted to oleic acid and conjugated linoleic acid (CLA), respectively...
  31. Asadollahpour Nanaei H, Ansari Mahyari S, Edriss M. Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle. Reprod Domest Anim. 2014;49:769-74 pubmed publisher
    ..located in the ATP-binding cassette superfamily G member 2 transporter (ABCG2), stearoyl-CoA desaturase 1 (SCD1) and leptin receptor (LEPR) genes on reproductive traits and somatic cell count (SCC)...
  32. Orrù L, Cifuni G, Piasentier E, Corazzin M, Bovolenta S, Moioli B. Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls. Meat Sci. 2011;87:344-8 pubmed publisher
    The aim was to investigate the effect of the genetic polymorphisms of leptin (LEP) and stearoyl-CoA desaturase (SCD1) genes on the fatty acid (FA) composition of the muscle of 103 Simmental bulls...
  33. Jiang Z, Michal J, Tobey D, Daniels T, Rule D, MacNeil M. Significant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle. Int J Biol Sci. 2008;4:345-51 pubmed
    Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle...
  34. Jacobs A, Dijkstra J, Hendriks W, van Baal J, van Vuuren A. Comparison between stearoyl-CoA desaturase expression in milk somatic cells and in mammary tissue of lactating dairy cows. J Anim Physiol Anim Nutr (Berl). 2013;97:353-62 pubmed publisher
    ..The SCD5 mRNA levels in mammary tissue compared with SCD1 were low, and for several milk somatic cell samples, SCD5 expression was even below the limit of detection...
  35. Rezamand P, Watts J, Yavah K, Mosley E, Ma L, Corl B, et al. Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues. J Dairy Res. 2014;81:333-9 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle...
  36. Xu T, Shen X, Seyfert H. Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A. BMC Mol Biol. 2016;17:16 pubmed publisher
    Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulating lipopolysaccharide (LPS)...