SCD

Summary

Gene Symbol: SCD
Description: stearoyl-CoA desaturase (delta-9-desaturase)
Alias: SCD1, acyl-CoA desaturase, delta(9)-desaturase, fatty acid desaturase, stearoyl-coenzyme A desaturase
Species: cow

Top Publications

  1. ncbi Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows
    Aileen F Keating
    National Diagnostics Centre, National University of Ireland, Galway, Ireland
    Mamm Genome 16:184-93. 2005
  2. ncbi Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins
    M Mele
    Dipartimento di Agronomia e Gestione dell Agroecosistema, University of Pisa, Italy
    J Dairy Sci 90:4458-65. 2007
  3. doi Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation
    A M Carvajal
    Instituto de Investigaciones Agropecuarias INIA Remehue, Osorno, Chile
    Genet Mol Res 15:. 2016
  4. doi A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population
    C Li
    College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China
    Anim Genet 47:483-90. 2016
  5. doi Regulation of Stearoyl Coenzyme A Desaturase 1 Gene Promoter in Bovine Mammary Cells
    O di Martino
    a Department of Biology, University of Naples Federico II, Naples, Italy
    Anim Biotechnol 26:251-9. 2015
  6. doi Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle
    H Asadollahpour Nanaei
    Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, Iran
    Reprod Domest Anim 49:769-74. 2014
  7. doi Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues
    Pedram Rezamand
    Department of Animal and Veterinary Science, University of Idaho, Moscow Idaho 83844
    J Dairy Res 81:333-9. 2014
  8. doi Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid
    Seong Ho Choi
    Department of Animal Science, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
    Amino Acids 46:353-66. 2014
  9. doi Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing
    Andrea Herdmann
    Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany
    J Agric Food Chem 58:8314-21. 2010
  10. doi The polymorphisms of stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes and their association with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls
    L Barton
    Institute of Animal Science, Prague 10, CZ 104 01, Czech Republic
    Meat Sci 85:15-20. 2010

Scientific Experts

  • C Li
  • S Duchemin
  • Nicolò P P Macciotta
  • Zhihua Jiang
  • H Soyeurt
  • M Mele
  • Patrick M Kgwatalala
  • L Barton
  • G Conte
  • A A A Jacobs
  • B Moioli
  • A Schennink
  • R M Demeter
  • Aileen F Keating
  • A M Carvajal
  • O di Martino
  • H Asadollahpour Nanaei
  • Pedram Rezamand
  • Seong Ho Choi
  • Ana S H Costa
  • S Yokota
  • M A Alim
  • Mark A McGuire
  • Takahiro Narukami
  • L Orrù
  • M A Brooks
  • Benjamin A Corl
  • Andrea Herdmann
  • Guido Invernizzi
  • E Milanesi
  • H Ohsaki
  • Andrea J Lengi
  • J M Dezamour
  • P Huircan
  • I Subiabre
  • R Morales
  • B Kerr
  • E M Ungerfeld
  • A Troiano
  • R Tudisco
  • L Addi
  • M I Cutrignelli
  • V Calabro
  • S Calabro
  • F Infascelli
  • N Murru
  • A Guarino
  • Katherine M Yavah
  • Tryon A Wickersham
  • Sung Kwon Park
  • Guoyao Wu
  • L Anne Gilmore
  • Holly D Edwards
  • Liying Ma
  • Stephen B Smith
  • S Ansari Mahyari
  • Kyoung Hoon Kim
  • Jason S Watts
  • Erin E Mosley
  • M A Edriss
  • Virginia M R Pires
  • Marta P Silva
  • Carlos M G A Fontes
  • Cristina P M Alfaia
  • Rui J B Bessa
  • José A M Prates
  • G Guo
  • H Sugita
  • D X Sun
  • K Suzuki
  • Y Otomo
  • Y Zhang
  • N Shoji
  • L Liu
  • Q Zhang
  • M Hosono
  • Y P Fan
  • Y Suda
  • K Katoh
  • S L Zhang
  • A Ardiyanti
  • H Nakajima
  • X P Wu
  • Y Xie
  • Shinji Sasazaki
  • G F Cifuni
  • Masaaki Taniguchi
  • S Bovolenta
  • Takuya Nogi
  • Kenji Oyama

Detail Information

Publications35

  1. ncbi Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows
    Aileen F Keating
    National Diagnostics Centre, National University of Ireland, Galway, Ireland
    Mamm Genome 16:184-93. 2005
    ..of dietary polyunsaturated fatty acids (PUFA) in the rumen, and by the action of mammary Stearoyl-CoA desaturase (Scd)...
  2. ncbi Stearoyl-coenzyme A desaturase gene polymorphism and milk fatty acid composition in Italian Holsteins
    M Mele
    Dipartimento di Agronomia e Gestione dell Agroecosistema, University of Pisa, Italy
    J Dairy Sci 90:4458-65. 2007
    ..Stearoyl-CoA desaturase (SCD) is a key enzyme in mammary lipid metabolism because it is able to add a double bond in the cis delta9-position in ..
  3. doi Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation
    A M Carvajal
    Instituto de Investigaciones Agropecuarias INIA Remehue, Osorno, Chile
    Genet Mol Res 15:. 2016
    ..Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated...
  4. doi A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population
    C Li
    College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China
    Anim Genet 47:483-90. 2016
    ..8-Mb region (20.3-22.1 Mb) on chromosome 26 underlying the SCD gene and were highly significantly associated with C14:1 or C14 index...
  5. doi Regulation of Stearoyl Coenzyme A Desaturase 1 Gene Promoter in Bovine Mammary Cells
    O di Martino
    a Department of Biology, University of Naples Federico II, Naples, Italy
    Anim Biotechnol 26:251-9. 2015
    Stearoyl-Coenzyme A desaturase 1 (SCD1) belongs to the fatty acid family of desaturases...
  6. doi Effect of LEPR, ABCG2 and SCD1 gene polymorphisms on reproductive traits in the Iranian Holstein cattle
    H Asadollahpour Nanaei
    Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, Iran
    Reprod Domest Anim 49:769-74. 2014
    ..located in the ATP-binding cassette superfamily G member 2 transporter (ABCG2), stearoyl-CoA desaturase 1 (SCD1) and leptin receptor (LEPR) genes on reproductive traits and somatic cell count (SCC)...
  7. doi Relationship between stearoyl-CoA desaturase 1 gene expression, relative protein abundance, and its fatty acid products in bovine tissues
    Pedram Rezamand
    Department of Animal and Veterinary Science, University of Idaho, Moscow Idaho 83844
    J Dairy Res 81:333-9. 2014
    Stearoyl-CoA desaturase 1 (SCD1) greatly contributes to the unsaturated fatty acids present in milk and meat of cattle...
  8. doi Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid
    Seong Ho Choi
    Department of Animal Science, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
    Amino Acids 46:353-66. 2014
    ..we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c...
  9. doi Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing
    Andrea Herdmann
    Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany
    J Agric Food Chem 58:8314-21. 2010
    ..acid (ALA) versus linoleic acid (LA) on meat quality, fatty acid composition, and stearoyl-CoA desaturase (SCD) activity in longissimus muscle (MLD) and subcutaneous adipose tissue (SAT) of German Holstein bulls and the ..
  10. doi The polymorphisms of stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes and their association with the fatty acid profile of muscle and subcutaneous fat in Fleckvieh bulls
    L Barton
    Institute of Animal Science, Prague 10, CZ 104 01, Czech Republic
    Meat Sci 85:15-20. 2010
    The previously reported genetic polymorphisms of the stearoyl-CoA desaturase (SCD1) and sterol regulatory element binding protein-1 (SREBP-1) genes were investigated in Fleckvieh bulls using the PCR-RFLP and AS-PCR methods, respectively...
  11. doi Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle
    G Conte
    Dipartimento di Agronomia e Gestione dell Agroecosistema, University of Pisa, 56124, Italy
    J Dairy Sci 93:753-63. 2010
    Several lipogenic genes have been shown to have effects on lipid metabolism: stearoyl CoA desaturase 1 (SCD1) catalyzes the desaturation of several fatty acids (FA) in the cis-Delta(9) position in mammary glands of ruminant animals, ..
  12. doi Stearoyl-CoA desaturase 1 3'UTR SNPs and their influence on milk fatty acid composition of Canadian Holstein cows
    P M Kgwatalala
    Department of Animal Science, McGill University, 21111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada
    J Anim Breed Genet 126:394-403. 2009
    Stearoyl-CoA desaturase 1 (SCD1) catalyses the synthesis of conjugated linoleic acid (CLA) and mono-unsaturated fatty acids (MUFA) in the mammary gland of ruminant animals...
  13. doi Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1)
    A Schennink
    Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
    J Dairy Sci 91:2135-43. 2008
    ..23 +/- 0.07 for conjugated linoleic acid (CLA) index to 0.46 +/- 0.09 for C16 index. We genotyped the cows for the SCD1 A293V and DGAT1 K232A polymorphisms, which are known to alter milk fatty acid composition...
  14. doi Genetic background and diet impact beef fatty acid composition and stearoyl-CoA desaturase mRNA expression
    Ana S H Costa
    CIISA, Faculdade de Medicina Veterinaria, Universidade Tecnica de Lisboa, Av da Universidade Técnica, Pólo Universitário do Alto da Ajuda, 1300 477, Lisboa, Portugal
    Lipids 48:369-81. 2013
    ..on lipid metabolism in the muscle, which may be, at least partially, modulated by the stearoyl-CoA desaturase (SCD) gene expression levels...
  15. doi Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions
    S Duchemin
    Animal Breeding and Genomics Centre, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
    J Dairy Sci 96:592-604. 2013
    ..effects of acyl-coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) K232A, and stearoyl-coenzyme A desaturase 1 (SCD1) A293V polymorphisms for milk fat composition in winter and summer, and tested for genotype by season interactions ..
  16. doi Genetic effects of stearoyl-coenzyme A desaturase (SCD) polymorphism on milk production traits in the Chinese dairy population
    M A Alim
    College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, China
    Mol Biol Rep 39:8733-40. 2012
    Stearoyl-CoA desaturase (SCD) is a multifunctional complex enzyme important in the cellular biosynthesis of fatty acids. The present study was to investigate the association of the SCD gene with milk production traits in dairy cattle...
  17. doi Sustained upregulation of stearoyl-CoA desaturase in bovine mammary tissue with contrasting changes in milk fat synthesis and lipogenic gene networks caused by lipid supplements
    Guido Invernizzi
    Mammalian NutriPhysioGenomics, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Funct Integr Genomics 10:561-75. 2010
    ..Expression of THRSP decreased by day 7 with both diets and returned to basal levels by day 21. SCD expression increased linearly through 7 days and remained elevated with both diets, a likely mechanism to ensure ..
  18. doi Association analyses of single nucleotide polymorphisms in the LEP and SCD1 genes on the fatty acid profile of muscle fat in Simmental bulls
    L Orrù
    Consiglio per la Ricerca e la Sperimentazione in Agricoltura, CRA GPG, via San Protaso 302, 29017 Fiorenzuola d Arda, Italy
    Meat Sci 87:344-8. 2011
    The aim was to investigate the effect of the genetic polymorphisms of leptin (LEP) and stearoyl-CoA desaturase (SCD1) genes on the fatty acid (FA) composition of the muscle of 103 Simmental bulls...
  19. doi Subcutaneous and intramuscular adipose tissue stearoyl-coenzyme A desaturase gene expression and fatty acid composition in calf- and yearling-fed Angus steers
    M A Brooks
    Department of Animal Science, Texas Agricultural Experiment Station, Texas A and M University, College Station 77843, USA
    J Anim Sci 89:2556-70. 2011
    We proposed that stearoyl-CoA desaturase (SCD) activity dictates fatty acid composition of adipose tissue and muscle in beef cattle, regardless of ruminal or hepatic fatty acid hydrogenation or desaturation...
  20. doi Effect of DNA polymorphisms related to fatty acid composition in adipose tissue of Holstein cattle
    Takahiro Narukami
    Graduate School of Agricultural Science, Kobe University, Nada, Japan
    Anim Sci J 82:406-11. 2011
    ..we investigated the effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) on fatty acid composition in intramuscular ..
  21. doi Effect of sex and age on bovine muscle and adipose fatty acid composition and stearoyl-CoA desaturase mRNA expression
    L Barton
    Institute of Animal Science, Prague 10, CZ 104 01, Czech Republic
    Meat Sci 89:444-50. 2011
    ..The expression of the stearoyl-CoA desaturase gene was higher in the adipose tissue of heifers compared to bulls, and its variation partly contributed to sex- and age-differences in the FA composition of bovine adipose tissue...
  22. doi Association analyses of single nucleotide polymorphisms in bovine stearoyl-CoA desaturase and fatty acid synthase genes with fatty acid composition in commercial cross-bred beef steers
    C Li
    Agriculture and Agri Food Canada, Lacombe Research Centre, 6000 C and E Trail, Lacombe, Alberta, Canada
    Anim Genet 43:93-7. 2012
    ..coding single nucleotide polymorphisms (SNPs) of bovine stearoyl-CoA desaturase (delta-9-desaturase) (SCD) (c...
  23. doi Comparison between stearoyl-CoA desaturase expression in milk somatic cells and in mammary tissue of lactating dairy cows
    A A A Jacobs
    Animal Nutrition Group, Wageningen University, Wageningen, The Netherlands
    J Anim Physiol Anim Nutr (Berl) 97:353-62. 2013
    ..The SCD5 mRNA levels in mammary tissue compared with SCD1 were low, and for several milk somatic cell samples, SCD5 expression was even below the limit of detection...
  24. doi Contributions of FASN and SCD gene polymorphisms on fatty acid composition in muscle from Japanese Black cattle
    S Yokota
    Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, 981 8555, Japan
    Anim Genet 43:790-2. 2012
    The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition...
  25. ncbi Single nucleotide polymorphisms in the open reading frame of the stearoyl-CoA desaturase gene and resulting genetic variants in Canadian Holstein and Jersey cows
    Patrick M Kgwatalala
    Department of Animal Science, McGill University, Ste Anne de Bellevue, QB, Canada
    DNA Seq 18:357-62. 2007
    Stearoyl-CoA desaturase (SCD) catalyzes the synthesis of conjugated linoleic acid (CLA) and mono-unsaturated fatty acids (MUFA) from their saturated counterparts in the mammary gland and adipose tissue of ruminant animals...
  26. ncbi Cloning and characterization of bovine stearoyl CoA desaturasel cDNA from adipose tissues
    M Chung
    Department of Animal Science and Technology, School of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Suweon, Korea
    Biosci Biotechnol Biochem 64:1526-30. 2000
    ..and more than 88% similarities to other mammalian SCD1s, indicating that the clones are the cDNAs for the bovine SCD1. The transcript size of the bovine SCD1 was about 4...
  27. ncbi Short communication: Effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk
    B Moioli
    CRA Istituto Sperimentale per la Zootecnia, via Salaria 31, 00016 Monterotondo, Italy
    J Dairy Sci 90:3553-8. 2007
    The effect of the stearoyl-CoA desaturase (SCD) gene on milk fatty acid composition was tested. Cows of 3 breeds of northern Italy, Piedmontese, Valdostana, and Jersey, were genotyped at exon 5 of the SCD gene...
  28. ncbi Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5
    Andrea J Lengi
    Department of Dairy Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Lipids 42:499-508. 2007
    ..time a second SCD isoform in cattle, which appears to be an ortholog of human SCD5 rather than a homolog of bovine SCD1 or any of the described murine SCD isoforms...
  29. ncbi Characterization and regulation of the bovine stearoyl-CoA desaturase gene promoter
    Aileen F Keating
    Department of Animal Science, University of Vermont, Burlington, VT 05405, USA
    Biochem Biophys Res Commun 344:233-40. 2006
    The bovine stearoyl-CoA desaturase (Scd) gene plays an important role in the bovine mammary gland where substrates such as stearic and vaccenic acids are converted to oleic acid and conjugated linoleic acid (CLA), respectively...
  30. pmc Significant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle
    Zhihua Jiang
    Department of Animal Sciences, Washington State University, Pullman, WA 99164 6351, USA
    Int J Biol Sci 4:345-51. 2008
    Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle...
  31. ncbi Stearoyl-CoA desaturase mRNA expression during bovine adipocyte differentiation in primary culture derived from Japanese Black and Holstein cattle
    H Ohsaki
    Laboratory of Animal Breeding and Genetics, Graduate School of Science and Technology, Kobe University, Kobe, Japan
    Comp Biochem Physiol A Mol Integr Physiol 148:629-34. 2007
    Stearoyl-CoA desaturase (SCD) catalyzes the synthesis of monounsaturated fatty acids (MUFAs). In cattle, the MUFAs are related to softness and flavor of meat...
  32. doi Stearoyl CoA desaturase (SCD) gene polymorphisms in Italian cattle breeds
    E Milanesi
    Sezione di Zootecnica Agraria, Dipartimento di Scienze Animali, Universita degli Studi di Milano, Milano, Italy
    J Anim Breed Genet 125:63-7. 2008
    Stearoyl CoA desaturase (SCD) is the key enzyme involved in the endogenous synthesis of conjugated linoleic acid (CLA) in ruminants...
  33. doi Association between a polymorphism at the stearoyl CoA desaturase locus and milk production traits in Italian Holsteins
    N P P Macciotta
    Dipartimento di Scienze Zootecniche, Universita di Sassari, Via De Nicola 9, 07100, Sassari, Italy
    J Dairy Sci 91:3184-9. 2008
    Associations between stearoyl-CoA desaturase (SCD) gene polymorphisms and milk production traits (milk, fat, and protein yields, fat and protein contents, somatic cell score) were investigated on a sample of 701 lactations of 313 Italian ..
  34. doi Effects of milk fat composition, DGAT1, and SCD1 on fertility traits in Dutch Holstein cattle
    R M Demeter
    Animal Breeding and Genomics Centre, Wageningen University, 6700 AH, Wageningen, The Netherlands
    J Dairy Sci 92:5720-9. 2009
    ..this study were to examine 1) the effect of milk fat composition, and 2) the effect of polymorphisms of DGAT1 and SCD1 genes on female fertility in commercial Dutch Holstein-Friesian cattle...
  35. doi Variation of Delta 9-desaturase activity in dairy cattle
    H Soyeurt
    Gembloux Agricultural University, Animal Science Unit, B 5030 Gembloux, Belgium
    J Dairy Sci 91:3211-24. 2008
    ..The positive genetic correlations observed between %MONO and the ratios of C14:1 cis-9 to C14:0 (0.72), C16:1 cis-9 to C16:0 (0.62), and C18:1 cis to C18:0 (0.97) showed that %MONO is linked to the Delta(9)-desaturase activity...