Gene Symbol: RELA
Description: RELA proto-oncogene, NF-kB subunit
Alias: transcription factor p65, NF-kappaB transcription factor p65 subunit, v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
Orr A, Sanders J, Bevard M, Coleman E, Sarembock I, Schwartz M. The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosis. J Cell Biol. 2005;169:191-202 pubmed
..Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-kappaB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. ..
Doleschall M, Mayer B, Cervenak J, Cervenak L, Kacskovics I. Cloning, expression and characterization of the bovine p65 subunit of NFkappaB. Dev Comp Immunol. 2007;31:945-61 pubmed
The full length coding sequence of the cattle transcription factor p65 was isolated and cloned. The cloned bovine p65 was expressed in mammalian cells, and it induced the NF-kappaB-specific luciferase reporter gene expression...
Yang W, Zerbe H, Petzl W, Brunner R, Günther J, Draing C, et al
. Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. Mol Immunol. 2008;45:1385-97 pubmed
..Rather, the pathogen causing subclinical mastitis impairs NF-kappaB activation in MEC thereby severely weakening the immune response in the udder. ..
Liu S, Shi X, Bauer I, Günther J, Seyfert H. Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-?B p65 and C/EBP? in mammary epithelial cells. Mol Immunol. 2011;48:895-908 pubmed publisher
Li X, Huang W, Gu J, Du X, Lei L, Yuan X, et al
. SREBP-1c overactivates ROS-mediated hepatic NF-ÎºB inflammatory pathway in dairy cows with fatty liver. Cell Signal. 2015;27:2099-109 pubmed publisher
Fredericksen F, Carrasco G, Villalba M, OlavarrÃa V. Cytopathic BVDV-1 strain induces immune marker production in bovine cells through the NF-ÎºB signaling pathway. Mol Immunol. 2015;68:213-22 pubmed publisher
..Additionally, this is the first report to find BVDV-1 modulating the activation of cytokine production and transcriptions factors mainly through the NF-ÎºB pathway in vertebrates. ..
Grimaldo S, Tian F, Li L. Sensitization of endothelial cells to VEGI-induced apoptosis by inhibiting the NF-kappaB pathway. Apoptosis. 2009;14:788-95 pubmed publisher
..These findings indicate that a combination therapy using VEGI and NF-kappaB inhibitors could be a potent approach for cancer treatment. ..