Gene Symbol: PRKD1
Description: protein kinase D1
Alias: serine/threonine-protein kinase D1
Ha C, Wang W, Jhun B, Wong C, Hausser A, Pfizenmaier K, et al
. Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. J Biol Chem. 2008;283:14590-9 pubmed publisher
..These findings suggest that the PKD-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis. ..
Shapiro B, Olala L, Arun S, Parker P, George M, Bollag W. Angiotensin II-activated protein kinase D mediates acute aldosterone secretion. Mol Cell Endocrinol. 2010;317:99-105 pubmed publisher
..Thus, we demonstrate for the first time that PKD mediates acute AngII-induced aldosterone secretion. ..
Olala L, Seremwe M, Tsai Y, Bollag W. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. Mol Cell Endocrinol. 2013;366:31-7 pubmed publisher
..These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells. ..
Olala L, Choudhary V, Johnson M, Bollag W. Angiotensin II-induced protein kinase D activates the ATF/CREB family of transcription factors and promotes StAR mRNA expression. Endocrinology. 2014;155:2524-33 pubmed publisher
..Thus, these data provide insight into the previously reported role of PKD in AngII-induced acute aldosterone production, providing a mechanism by which PKD may be mediating steroidogenesis in primary bovine adrenal glomerulosa cells. ..
Olala L, Shapiro B, Merchen T, Wynn J, Bollag W. Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production. Mol Cell Endocrinol. 2014;392:173-81 pubmed publisher
..Taken together, our results demonstrate that AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production. ..