PRKCB

Summary

Gene Symbol: PRKCB
Description: protein kinase C beta
Alias: PRKCB1, protein kinase C beta type, PKC-B, PKC-beta, protein kinase C, beta 1 polypeptide
Species: cow
Products:     PRKCB

Top Publications

  1. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988;334:661-5 pubmed
  2. Coussens L, Parker P, Rhee L, Yang Feng T, Chen E, Waterfield M, et al. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science. 1986;233:859-66 pubmed
    ..The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses. ..
  3. Whalen S, Gingras A, Amankwa L, Mader S, Branton P, Aebersold R, et al. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. J Biol Chem. 1996;271:11831-7 pubmed
    ..This suggests a two-step model for the phosphorylation (and activation) of eIF4E by growth factors and hormones: first, dissociation of eIF4E from 4E-BPs, followed by eIF4E phosphorylation. ..
  4. Park K, Li Q, Rask Madsen C, Mima A, Mizutani K, Winnay J, et al. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol. 2013;33:3227-41 pubmed publisher
    ..Thus, AngII or PKC? activation can phosphorylate Ser303 and Ser675 in IRS2 to inhibit insulin-induced p-Tyr911 and its anti-atherogenic actions (p-Akt/eNOS) in endothelial cells. ..