Gene Symbol: PRKCA
Description: protein kinase C alpha
Alias: PKRCA, protein kinase C alpha type, PKC-A, PKC-alpha
Species: cow
Products:     PRKCA

Top Publications

  1. Parker P, Coussens L, Totty N, Rhee L, Young S, Chen E, et al. The complete primary structure of protein kinase C--the major phorbol ester receptor. Science. 1986;233:853-9 pubmed
  2. Cazaubon S, Parker P. Identification of the phosphorylated region responsible for the permissive activation of protein kinase C. J Biol Chem. 1993;268:17559-63 pubmed
    ..Cazaubon, S., and Parker, P. J. (1992) Biochem. J. 283, 515-518). By site-directed mutagenesis of the PKC alpha cDNA, it has been shown that a region including 3 threonine residues (Thr-494, Thr-495, and Thr-497), present in ..
  3. Whalen S, Gingras A, Amankwa L, Mader S, Branton P, Aebersold R, et al. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. J Biol Chem. 1996;271:11831-7 pubmed
    ..This suggests a two-step model for the phosphorylation (and activation) of eIF4E by growth factors and hormones: first, dissociation of eIF4E from 4E-BPs, followed by eIF4E phosphorylation. ..
  4. Haines R, Corbin K, Pendleton L, Eichler D. Protein kinase C? phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem. 2012;287:26168-76 pubmed publisher
  5. Aschrafi A, Franzen R, Shabahang S, Fabbro D, Pfeilschifter J, Huwiler A. Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain. Biochim Biophys Acta. 2003;1634:30-9 pubmed
    ..In summary, our data provide evidence that ceramide either directly or indirectly interacts with the Ca(2+)-dependent lipid binding C2 domain of PKCalpha and thereby induces translocation of the enzyme to the Golgi compartment. ..
  6. Rider M, VanDamme J, Lebeau E, Vertommen D, Vidal H, Rousseau G, et al. The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. Biochem J. 1992;285 ( Pt 2):405-11 pubmed
    ..Taken together, these findings demonstrate that the 58,000- and 54,000-M(r) forms of bovine heart PFK-2/FBPase-2 result from alternative splicing of the same primary transcript. ..
  7. Coutinho I, Pereira C, Pereira G, Gon alves J, C rte Real M, Saraiva L. Distinct regulation of p53-mediated apoptosis by protein kinase C?, ?, ? and ?: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Exp Cell Res. 2011;317:1147-58 pubmed publisher
    ..Finally, it underscores a major role of PKC? and ? as positive regulators of p53-mediated apoptosis, and therefore as promising therapeutic targets in cancer...
  8. Olala L, Shapiro B, Merchen T, Wynn J, Bollag W. Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production. Mol Cell Endocrinol. 2014;392:173-81 pubmed publisher
    ..Taken together, our results demonstrate that AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production. ..
  9. Staudinger J, Zhou J, Burgess R, Elledge S, Olson E. PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol. 1995;128:263-71 pubmed
    ..We used the yeast two-hybrid system to identify proteins that interact with activated PKC alpha. Using the catalytic region of PKC fused to the DNA binding domain of yeast GAL4 as "bait" to screen a ..

More Information


  1. Zimmermann G, Taussig R. Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunits. J Biol Chem. 1996;271:27161-6 pubmed publisher
  2. Bornancin F, Parker P. Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state. J Biol Chem. 1997;272:3544-9 pubmed
    ..These results are discussed in the context of a working model of PKCalpha behavior, providing insight into the workings of other kinases with equivalent sites of phosphorylation. ..
  3. Schlecht W, Zhou Z, Li K, Rieck D, Ouyang Y, Dong W. FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation. Arch Biochem Biophys. 2014;550-551:1-11 pubmed publisher
    ..These changes can either decrease or increase Ca(2+)-sensitivity and likely play an important role in cardiac regulation. ..
  4. Rask Madsen C, King G. Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol. 2008;28:919-24 pubmed publisher
    ..By regulating VEGFR2 expression and activation, PKC-epsilon expression is critical for activation of Akt and eNOS by VEGF and contributes to VEGF-stimulated Erk activation, whereas PKC-alpha has opposite effects. ..
  5. Bass Zubek A, Hobbs R, Amargo E, Garcia N, Hsieh S, Chen X, et al. Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Biol. 2008;181:605-13 pubmed publisher
    ..we provide evidence that PKP2 governs DP assembly dynamics by scaffolding a DP-PKP2-protein kinase C alpha (PKC alpha) complex, which is disrupted by PKP2 knockdown...
  6. Sheldon K, Maldonado E, Lemasters J, Rostovtseva T, Bezrukov S. Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS ONE. 2011;6:e25539 pubmed publisher
    ..Our findings suggest a novel functional link between serine/threonine kinase signaling pathways, mitochondrial respiration, and the highly dynamic microtubule network which is characteristic of cancerogenesis and cell proliferation...
  7. Yeong S, Zhu Y, Smith D, Verma C, Lim W, Tan B, et al. The last 10 amino acid residues beyond the hydrophobic motif are critical for the catalytic competence and function of protein kinase Calpha. J Biol Chem. 2006;281:30768-81 pubmed
    ..Molecules that bind preferentially to the very C terminus of distinct PKC isozymes and suppress their catalytic activity may constitute a new class of selective inhibitors of PKC. ..
  8. Rotman T, Etkovitz N, Spiegel A, Rubinstein S, Breitbart H. Protein kinase A and protein kinase C(alpha)/PPP1CC2 play opposing roles in the regulation of phosphatidylinositol 3-kinase activation in bovine sperm. Reproduction. 2010;140:43-56 pubmed publisher
    ..that short-time activation of protein kinase A (PRKA, PKA) leads to PI3K activation and protein kinase C(alpha)(PRKCA, PKC(alpha)) inhibition...
  9. Venardos K, Enriquez C, Marshall T, Chin Dusting J, Ahlers B, Kaye D. Protein kinase C mediated inhibition of endothelial L-arginine transport is mediated by MARCKS protein. J Mol Cell Cardiol. 2009;46:86-92 pubmed publisher
    ..05). Moreover antisense inhibition of MARCKS abolished the PMA effect on L-arginine transport. PKC dependent mechanisms regulate the transport of L-arginine, mediated via process involving MARCKS. ..
  10. Kuznetsov S, Larkin D, Kaftanovskaia E, Ivanova E, Astakhova N, Cheriakene O, et al. [Chromosome localization and analysis of synteny analysis of some genes in swine, cattle, and sheep (Artiodactyla)]. Genetika. 1998;34:1200-4 pubmed
    ..Genes NF1, RARA, PRKCA, and ERBB2 were assigned to chr 12 in swine; TK1 and UMPH2, to chr 19 in cattle; and TK1, UMPH2, and PEPA, to chr ..
  11. Roy S, Chakraborti T, Chowdhury A, Chakraborti S. Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells. J Biochem. 2013;153:289-302 pubmed publisher
  12. Staudinger J, Lu J, Olson E. Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J Biol Chem. 1997;272:32019-24 pubmed
    ..Association of PKCalpha with PICK1 provides a potential mechanism for the selective targeting of PKCalpha to unique subcellular sites. ..
  13. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988;334:661-5 pubmed