Gene Symbol: PPID
Description: peptidylprolyl isomerase D
Alias: CYP-40, peptidyl-prolyl cis-trans isomerase D, 40 kDa peptidyl-prolyl cis-trans isomerase, PPIase D, cyclophilin-40, cyclophilin-related protein, estrogen receptor-binding cyclophilin, peptidylprolyl isomerase D (cyclophilin D), rotamase D
Species: cow
Products:     PPID

Top Publications

  1. Ratajczak T, Carrello A, Mark P, Warner B, Simpson R, Moritz R, et al. The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59). J Biol Chem. 1993;268:13187-92 pubmed
    ..Both immunophilins may have important roles in receptor assembly and may represent a new category of ligand- and calcium-dependent modulators of protein function. ..
  2. Aulik N, Hellenbrand K, Kisiela D, Czuprynski C. Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria. Microb Pathog. 2011;50:168-78 pubmed publisher
    ..These data confirm that LKT binds to bovine neutrophil mitochondria, but indicate there are distinctions between neutrophil and BL-3 mitochondria that might reflect differences in cyclophilin D...
  3. Anderson S, de Bruijn M, Coulson A, Eperon I, Sanger F, Young I. Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome. J Mol Biol. 1982;156:683-717 pubmed
  4. Mok D, Allan R, Carrello A, Wangoo K, Walkinshaw M, Ratajczak T. The chaperone function of cyclophilin 40 maps to a cleft between the prolyl isomerase and tetratricopeptide repeat domains. FEBS Lett. 2006;580:2761-8 pubmed
    b>Cyclophilin 40 (CyP40), an immunophilin cochaperone present in steroid receptor-Hsp90 complexes, contains an N-terminal peptidylprolyl isomerase (PPIase) domain separated from a C-terminal Hsp90-binding tetratricopeptide repeat (TPR) ..
  5. Atapattu D, Albrecht R, McClenahan D, Czuprynski C. Dynamin-2-dependent targeting of mannheimia haemolytica leukotoxin to mitochondrial cyclophilin D in bovine lymphoblastoid cells. Infect Immun. 2008;76:5357-65 pubmed publisher
    ..The results of this study show that LKT trafficking and LKT-mediated cell death involve dynamin-2 and cyclophilin D, in a process that can be prevented by the mitochondrial membrane-protecting function of CSA...
  6. Kieffer L, Seng T, Li W, Osterman D, Handschumacher R, Bayney R. Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. J Biol Chem. 1993;268:12303-10 pubmed
    ..The homology of CyP-40 to P59 suggests that CyP-40 might be involved in modulating the activity of biologically important receptors. ..
  7. Taylor P, Dornan J, Carrello A, Minchin R, Ratajczak T, Walkinshaw M. Two structures of cyclophilin 40: folding and fidelity in the TPR domains. Structure. 2001;9:431-8 pubmed
    ..The X-ray structures are consistent with the role of Cyclophilin 40 as a multifunctional signaling protein involved in a variety of protein-protein interactions...
  8. Okada M, Hatakeyama T, Itoh H, Tokuta N, Tokumitsu H, Kobayashi R. S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. J Biol Chem. 2004;279:4221-33 pubmed
    ..The results demonstrate a novel physiological function for S100A1 and bring us closer to a comprehensive understanding of the molecular mechanisms of the Hsp70/Hsp90 multichaperone complex. ..
  9. Shimamoto S, Kubota Y, Tokumitsu H, Kobayashi R. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. FEBS Lett. 2010;584:1119-25 pubmed publisher
    ..In this work, we have identified Cyclophilin 40 (CyP40) and FKBP52 (called immunophilins) as novel targets of S100 proteins...

More Information


  1. Kieffer L, Thalhammer T, Handschumacher R. Isolation and characterization of a 40-kDa cyclophilin-related protein. J Biol Chem. 1992;267:5503-7 pubmed
    ..Cyp-40 possesses peptidyl-prolyl cis-trans isomerase activity which is less sensitive to inhibition by cyclosporin A (IC50 = 300 nM) than is CyP-18 (IC50 = 20 nM). ..
  2. Carrello A, Allan R, Morgan S, Owen B, Mok D, Ward B, et al. Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones. 2004;9:167-81 pubmed
    ..exists as a multicomponent complex that includes heat shock protein (Hsp)90; one of the immunophilins cyclophilin 40 (CyP40), FKBP51, or FKBP52; and an additional p23 protein component...