Gene Symbol: PLG
Description: plasminogen
Alias: LPA, plasminogen, lipoprotein, Lp(a), plasmin
Species: cow
Products:     PLG

Top Publications

  1. Chou W, Yu T, Chen S, Peh H, Liu W, Chen M, et al. TNFalpha-mediated plasminogen activation on neutrophils is involved in the high plasmin activity in mammary secretion of drying-off cows. J Dairy Res. 2009;76:459-68 pubmed publisher
    Interactions between inflammatory cytokines and plasminogen (Pg) activation system on immune cells are yet to be established...
  2. Marti T, Schaller J, Rickli E, Schmid K, Kamerling J, Gerwig G, et al. The N- and O-linked carbohydrate chains of human, bovine and porcine plasminogen. Species specificity in relation to sialylation and fucosylation patterns. Eur J Biochem. 1988;173:57-63 pubmed
    The structures of the N- and O-glycans of human, bovine and porcine plasminogen were determined by 500-MHz 1H-NMR spectroscopy...
  3. Maissen M, Roeckl C, Glatzel M, Goldmann W, Aguzzi A. Plasminogen binds to disease-associated prion protein of multiple species. Lancet. 2001;357:2026-8 pubmed
  4. Westergaard U, Andersen M, Heegaard C, Fedosov S, Petersen T. Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator. Eur J Biochem. 2003;270:1850-4 pubmed
    In the search for new ligands for the plasminogen kringle 4 binding-protein tetranectin, it has been found by ligand blot analysis and ELISA that tetranectin specifically bound to the plasminogen-like hepatocyte growth factor and tissue-..
  5. Ward P, Field T, Rosey E, Abu Median A, Lincoln R, Leigh J. Complex interactions between bovine plasminogen and streptococcal plasminogen activator PauA. J Mol Biol. 2004;342:1101-14 pubmed
    The interactions between bovine plasminogen and the streptococcal plasminogen activator PauA that culminate in the generation of plasmin are not fully understood...
  6. Schaller J, Moser P, Dannegger Müller G, Rösselet S, Kämpfer U, Rickli E. Complete amino acid sequence of bovine plasminogen. Comparison with human plasminogen. Eur J Biochem. 1985;149:267-78 pubmed
    The amino acid sequence of the single polypeptide chain of bovine plasminogen (786 residues, Mr 88092) was determined. Cleavage with CNBr yielded 13 fragments of which six originated from cleavage sites different from human plasminogen...
  7. Bohnsack R, Patel M, Olson L, Twining S, Dahms N. Residues essential for plasminogen binding by the cation-independent mannose 6-phosphate receptor. Biochemistry. 2010;49:635-44 pubmed publisher
    ..The CI-MPR is a receptor for plasminogen, and this interaction can be inhibited by lysine analogues...
  8. Malinowski D, Sadler J, Davie E. Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen. Biochemistry. 1984;23:4243-50 pubmed
    A cDNA library was constructed in pBR322 from bovine liver mRNA that was enriched for plasminogen mRNA by polysome immunoprecipitation...
  9. Silanikove N, Shapiro F, Shinder D. Acute heat stress brings down milk secretion in dairy cows by up-regulating the activity of the milk-borne negative feedback regulatory system. BMC Physiol. 2009;9:13 pubmed publisher
    ..The reduction in milk yield was associated with corresponding responses in plasminogen activator/plasminogen-plasmin activities, and with increased activity (concentration) of the (1-28) N-terminal ..

More Information


  1. Mondéjar I, Grullón L, García Vázquez F, Romar R, Coy P. Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes. Fertil Steril. 2012;97:453-61 pubmed publisher
    To detect plasminogen and plasminogen activators (PA) in oviduct and oocytes and to clarify the role of the plasminogen/plasmin system on mammalian fertilization. Experimental prospective study. Mammalian reproduction research laboratory...
  2. Zhang Y, Gladysheva I, Houng A, Reed G. Streptococcus uberis plasminogen activator (SUPA) activates human plasminogen through novel species-specific and fibrin-targeted mechanisms. J Biol Chem. 2012;287:19171-6 pubmed publisher
    Bacterial plasminogen (Pg) activators generate plasmin to degrade fibrin blood clots and other proteins that modulate the pathogenesis of infection, yet despite strong homology between mammalian Pgs, the activity of bacterial Pg ..