Gene Symbol: PLAUR
Description: plasminogen activator, urokinase receptor
Alias: urokinase plasminogen activator surface receptor, U-PAR, uPAR
Species: cow

Top Publications

  1. Baldi A, Pecorini C, Rebucci R, Saccone F, Cheli F, Miranda Ribera A, et al. Effect of Escherichia coli lipopolysaccharide on u-PA activity and u-PA and u-PAR RNA expression in a bovine mammary epithelial cell line. Res Vet Sci. 2012;93:758-62 pubmed publisher
    ..These data indicated that E. coli LPS led to an increase in u-PA activity and RNA expression of u-PA and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes...
  2. El Remessy A, Franklin T, Ghaley N, Yang J, Brands M, Caldwell R, et al. Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: role of the VEGF/uPAR pathway. PLoS ONE. 2013;8:e71868 pubmed publisher
    ..permeability of retinal endothelial cells (REC) by inducing expression of urokinase plasminogen activator receptor (uPAR)...
  3. Reuning U, Little S, Dixon E, Johnstone E, Bang N. Molecular cloning of cDNA for the bovine urokinase-type plasminogen activator receptor. Thromb Res. 1993;72:59-70 pubmed
    ..Southern blot analysis of genomic DNAs from 9 eukaryotic species suggests that the u-PAR gene is conserved in man, monkey, and cow. ..
  4. Heegaard C, Rasmussen L, Andreasen P. The plasminogen activation system in bovine milk: differential localization of tissue-type plasminogen activator and urokinase in milk fractions is caused by binding to casein and urokinase receptor. Biochim Biophys Acta. 1994;1222:45-55 pubmed
    ..R. and Tritsch, G.L. (1993) Fibrinolysis 7, 229-236), and the observed t-PA/casein binding suggests that the casein micelle, which also contains plasminogen, may serve as a matrix for t-PA-catalyzed plasminogen activation in milk. ..
  5. Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed
  6. Kreiling J, Byrd J, Deisz R, Mizukami I, Todd R, MacDonald R. Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR. J Biol Chem. 2003;278:20628-37 pubmed
    Urokinase-type plasminogen activator receptor (uPAR) binding by the mannose 6-phosphate/insulin-like growth factor II receptor (Man-6-P/IGF2R) is considered important to Man-6-P/IGF2R tumor suppressor function via regulation of cell ..
  7. Garcia D, Miceli D, Valdecantos P, Garcia E, Roldan Olarte M. Expression of urokinase type plasminogen activator receptor (uPAR) in the bovine oviduct: Relationship with uPA effect on oviductal epithelial cells. Res Vet Sci. 2014;97:118-23 pubmed publisher
    ..oviductal fluid component whose activity is regulated by binding to urokinase type plasminogen activator receptor (uPAR)...
  8. Krätzschmar J, Haendler B, Kojima S, Rifkin D, Schleuning W. Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid. Gene. 1993;125:177-83 pubmed
    ..Northern blot hybridization demonstrated a moderate induction of u-PA and u-PAR mRNA in bovine aortic endothelial cells after treatment with 10 nM and 1 microM retinoic acid for 8 hours. ..
  9. García D, Miceli D, Rizo G, García E, Valdecantos P, Roldán Olarte M. Expression and localization of urokinase-type plasminogen activator receptor in bovine cumulus-oocyte complexes. Zygote. 2016;24:230-5 pubmed publisher
    ..uPA usually binds to its receptor, uPAR, which is anchored to the plasma membrane through a glycosylphosphatidylinositol anchor...