Gene Symbol: PLAU
Description: plasminogen activator, urokinase
Alias: urokinase-type plasminogen activator, U-plasminogen activator, uPA, urokinase plasminogen activator preproprotein
Species: cow

Top Publications

  1. Cao M, Sahmi M, Lussier J, Price C. Plasminogen activator and serine protease inhibitor-E2 (protease nexin-1) expression by bovine granulosa cells in vitro. Biol Reprod. 2004;71:887-93 pubmed
    ..Casein zymography revealed that the cells secreted predominantly tissue-type PA (tPA) with urokinase (uPA) being associated mainly with cell lysates, and Western blot demonstrated that the cells secreted SerpinE2...
  2. Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed
  3. Mondéjar I, Grullón L, García Vázquez F, Romar R, Coy P. Fertilization outcome could be regulated by binding of oviductal plasminogen to oocytes and by releasing of plasminogen activators during interplay between gametes. Fertil Steril. 2012;97:453-61 pubmed publisher
    ..The plasminogen/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte. ..
  4. García D, Miceli D, Rizo G, García E, Valdecantos P, Roldán Olarte M. Expression and localization of urokinase-type plasminogen activator receptor in bovine cumulus-oocyte complexes. Zygote. 2016;24:230-5 pubmed publisher
    Urokinase-type plasminogen activator (uPA) is a serine protease involved in extracellular matrix remodeling through plasmin generation...
  5. Heegaard C, Rasmussen L, Andreasen P. The plasminogen activation system in bovine milk: differential localization of tissue-type plasminogen activator and urokinase in milk fractions is caused by binding to casein and urokinase receptor. Biochim Biophys Acta. 1994;1222:45-55 pubmed
    ..R. and Tritsch, G.L. (1993) Fibrinolysis 7, 229-236), and the observed t-PA/casein binding suggests that the casein micelle, which also contains plasminogen, may serve as a matrix for t-PA-catalyzed plasminogen activation in milk. ..
  6. Krätzschmar J, Haendler B, Kojima S, Rifkin D, Schleuning W. Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid. Gene. 1993;125:177-83 pubmed
    ..Northern blot hybridization demonstrated a moderate induction of u-PA and u-PAR mRNA in bovine aortic endothelial cells after treatment with 10 nM and 1 microM retinoic acid for 8 hours. ..
  7. Baldi A, Pecorini C, Rebucci R, Saccone F, Cheli F, Miranda Ribera A, et al. Effect of Escherichia coli lipopolysaccharide on u-PA activity and u-PA and u-PAR RNA expression in a bovine mammary epithelial cell line. Res Vet Sci. 2012;93:758-62 pubmed publisher
    ..These data indicated that E. coli LPS led to an increase in u-PA activity and RNA expression of u-PA and u-PAR in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes...
  8. Garcia D, Miceli D, Valdecantos P, Garcia E, Roldan Olarte M. Expression of urokinase type plasminogen activator receptor (uPAR) in the bovine oviduct: Relationship with uPA effect on oviductal epithelial cells. Res Vet Sci. 2014;97:118-23 pubmed publisher
    b>Urokinase type plasminogen activator (uPA) is an oviductal fluid component whose activity is regulated by binding to urokinase type plasminogen activator receptor (uPAR)...
  9. Roldán Olarte M, Maillo V, Sánchez Calabuig M, Beltrán Breña P, Rizos D, Gutierrez Adan A. Effect of urokinase type plasminogen activator on in vitro bovine oocyte maturation. Reproduction. 2017;154:231-240 pubmed publisher
    This study examines the impacts of the urokinase-type plasminogen activator (uPA) on the in vitro maturation (IVM) of bovine oocytes...