platelet endothelial cell adhesion molecule
Gene Symbol: platelet endothelial cell adhesion molecule
Description: platelet and endothelial cell adhesion molecule 1
Alias: platelet endothelial cell adhesion molecule, CD31 antigen, PECAM-1, platelet/endothelial cell adhesion molecule (CD31 antigen)
Osawa M, Masuda M, Harada N, Lopes R, Fujiwara K. Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Eur J Cell Biol. 1997;72:229-37 pubmed
..Our study is the first demonstration of inducible tyrosine phosphorylation of PECAM-1 and suggests involvement of PECAM-1 and Src family kinases in the sensing/signal transduction of mechanical stimuli in ECs. ..
Sumpio B, Yun S, Cordova A, Haga M, Zhang J, Koh Y, et al
. MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. J Biol Chem. 2005;280:11185-91 pubmed
Chiu Y, McBeath E, Fujiwara K. Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation. J Cell Biol. 2008;182:753-63 pubmed publisher
..We suggest that PECAM-1 and Fyn are essential components of a PECAM-1-based mechanosensory complex in ECs. ..
Tiwari R, Sullivan J, Czuprynski C. PECAM-1 is involved in neutrophil transmigration across Histophilus somni treated bovine brain endothelial cells. Microb Pathog. 2009;47:164-70 pubmed publisher
..Because platelet endothelial cell adhesion molecule-1 (PECAM-1) and endothelial nitric oxide synthase (eNOS) play fundamental roles in maintaining ..
Collins C, Guilluy C, Welch C, O Brien E, Hahn K, Superfine R, et al
. Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol. 2012;22:2087-94 pubmed publisher
..Endothelial cells (ECs) have numerous mechanotransducers, including platelet endothelial cell adhesion molecule-1 (PECAM-1) at cell-cell junctions and integrins at cell-matrix adhesions...
Stewart R, Kashour T, Marsden P. Vascular endothelial platelet endothelial adhesion molecule-1 (PECAM-1) expression is decreased by TNF-alpha and IFN-gamma. Evidence for cytokine-induced destabilization of messenger ribonucleic acid transcripts in bovine endothelial cells. J Immunol. 1996;156:1221-8 pubmed
..These findings provide evidence for cytokine-induced reciprocal regulation of transcripts of Ig-like adhesion molecules on vascular endothelium. ..
Sharma A, Yu C, Leung C, Trane A, Lau M, Utokaparch S, et al
. A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis. Arterioscler Thromb Vasc Biol. 2010;30:2196-204 pubmed publisher
..Our data describe a novel pathway for PECAM-1 regulation and broaden the functional scope of ferlins in angiogenesis and specialized ferlin-selective protein cargo trafficking in vascular settings. ..