Gene Symbol: NOS2
Description: nitric oxide synthase 2
Alias: NOS2A, iNOS, nitric oxide synthase, inducible, NOS type II, NOSII, inducible NO synthase, inducible NOS, inducible nitric oxide synthase, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes), peptidyl-cysteine S-nitrosylase NOS2
Species: cow
Products:     NOS2

Top Publications

  1. Adler H, Frech B, Thöny M, Pfister H, Peterhans E, Jungi T. Inducible nitric oxide synthase in cattle. Differential cytokine regulation of nitric oxide synthase in bovine and murine macrophages. J Immunol. 1995;154:4710-8 pubmed
    We assessed bovine bone marrow-derived macrophages and monocyte-derived macrophages for expression of inducible nitric oxide synthase (iNOS) activity. Both cell types expressed iNOS activity upon stimulation with Salmonella dublin (S...
  2. Zamberlam G, Portela V, de Oliveira J, Gon alves P, Price C. Regulation of inducible nitric oxide synthase expression in bovine ovarian granulosa cells. Mol Cell Endocrinol. 2011;335:189-94 pubmed publisher
    ..reportedly generate NO in response to gonadotrophins, suggesting that the regulated form of nitric oxide synthase (iNOS) is present...
  3. Li D, Liu Y, Li Y, Lv Y, Pei X, Guo D. Significance of nitric oxide concentration in plasma and uterine secretes with puerperal endometritis in dairy cows. Vet Res Commun. 2010;34:315-21 pubmed publisher
    ..Expression level of NOS2 mRNA in endometrial biopsies from cows with puerperal endometritis was also higher and the highest expression of ..
  4. Ulbrich S, Rehfeld S, Bauersachs S, Wolf E, Rottmayer R, Hiendleder S, et al. Region-specific expression of nitric oxide synthases in the bovine oviduct during the oestrous cycle and in vitro. J Endocrinol. 2006;188:205-13 pubmed
    ..In the present study, the mRNA expression of the endothelial (eNOS) and inducible (iNOS) NO synthases were examined in bovine oviduct epithelial cells (BOEC) during the oestrous cycle...
  5. Pereira Suárez A, Estrada Chávez C, Arriaga Díaz C, Espinosa Cueto P, Mancilla R. Coexpression of NRAMP1, iNOS, and nitrotyrosine in bovine tuberculosis. Vet Pathol. 2006;43:709-17 pubmed
    In murine models the inducible nitric oxide synthase (iNOS) and the natural resistance associated macrophage protein (NRAMP1) play major roles in host defense against mycobacteria...
  6. Ozen A, Ergun E, Oztas E, Ergun L, Ozcan Z, Alabay B, et al. Immunohistochemical expression of nitric oxide synthase enzymes (iNOS, eNOS, nNOS) in the estrual and luteal phases of the sexual cycle in the cow oviduct. Anat Histol Embryol. 2013;42:384-93 pubmed publisher
    ..During the estrual phase, it was observed that inducible NOS expression showed a stronger positive reaction in the epithelium and muscle layer of the isthmus and ampulla ..
  7. Hayashi K, Hosoe M, Takahashi T. Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy. Anim Reprod Sci. 2012;134:150-7 pubmed publisher
    ..enzyme, EDNRA and EDNRB; receptor subtypes A and B) and endothelial and inducible nitric oxide synthases (eNOS and iNOS) in the bovine utero-placental unit during pregnancy...
  8. Li R, Li C, Gasbarre L. The vitamin D receptor and inducible nitric oxide synthase associated pathways in acquired resistance to Cooperia oncophora infection in cattle. Vet Res. 2011;42:48 pubmed publisher
    ..The expression of inducible nitric oxide synthase (NOS2) was strongly induced during reinfection but not during primary infection...
  9. Hermeyer K, Jacobsen B, Spergser J, Rosengarten R, Hewicker Trautwein M. Detection of Mycoplasma bovis by in-situ hybridization and expression of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase in the lungs of experimentally-infected calves. J Comp Pathol. 2011;145:240-50 pubmed publisher
    ..The aims of this study were: (1) to investigate the expression of inducible nitric oxide synthase (iNOS), nitrotyrosine (NT) and manganese superoxide dismutase (Mn-SOD) in the lung lesions of calves ..

More Information


  1. Sommer S, Pudrith C, Colvin C, Coussens P. Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Vet Immunol Immunopathol. 2009;128:44-52 pubmed publisher
    ..macrophages (MDM) responded to CD40L by up-regulating expression of genes encoding IL-6, TNFalpha, IL-8, iNOS, IL-10, and IL-12p40...
  2. Ea H, Uzan B, Rey C, Lioté F. Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes. Arthritis Res Ther. 2005;7:R915-26 pubmed
    ..OCP crystals induced nitric oxide (NO) production and inducible nitric oxide synthase (NOS) mRNA expression by isolated articular chondrocytes and cartilage fragments, in a dose-dependent ..
  3. Janowski T, Baranski W, Lukasik K, Skarzynski D, Rudowska M, Zdunczyk S. Prevalence of subclinical endometritis in repeat breeding cows and mRNA expression of tumor necrosis factor alpha and inducible nitric oxide synthase in the endometrium of repeat breeding cows with and without subclinical endometritis. Pol J Vet Sci. 2013;16:693-9 pubmed
    ..with cytobrush cytology b) to analyze mRNA expression of tumor necrosis factor alpha (TNFalpha) and inducible nitric oxide synthase (iNOS) in endometrial biopsy samples collected from repeat breeding cows with and without subclinical ..
  4. Pires P, Santos N, Adona P, Natori M, Schwarz K, de Bem T, et al. Endothelial and inducible nitric oxide synthases in oocytes of cattle. Anim Reprod Sci. 2009;116:233-43 pubmed publisher
    ..The following experiments were performed: (1) detection of the endothelial (eNOS) and inducible (iNOS) isoforms in the ovary by immunohistochemistry; (2) detection of eNOS and iNOS in the oocytes before and after in ..
  5. Raveenthiran S, Chowdhury T. Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs. Biomech Model Mechanobiol. 2009;8:273-83 pubmed publisher
    ..the combined effects of dynamic compression and the NH(2)-hep I or COOH-hep II FN-fs on the expression levels of iNOS and COX-2 and production of *NO and PGE(2) release...
  6. Xu G, Li Y, Yang J, Zhou X, Yin X, Liu M, et al. Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages. Mol Cell Biochem. 2007;302:1-7 pubmed
    ..such as MtbPPD, MbPPD, and BCG), followed by real-time RT-PCR assay for the mRNA expression level of TNF-alpha, iNOS, IL-6, and IL-12...
  7. Widdison S, Ashley G, Howard C, Coffey T. Characterisation of bovine inducible nitric oxide synthase. Vet Immunol Immunopathol. 2007;117:302-9 pubmed
    Inducible nitric oxide (iNOS) is an enzyme that catalyzes the production of the reactive nitrogen intermediate nitric oxide (NO)...
  8. Cheng Y, Huang C, Tsai H. Relationship of bovine NOS2 gene polymorphisms to the risk of bovine tuberculosis in Holstein cattle. J Vet Med Sci. 2016;78:281-6 pubmed publisher
    ..The inducible nitric oxide synthase (iNOS which is encoded by the NOS2 gene) plays a key role in the immunological control of a broad ..
  9. Heaton M, Harhay G, Bennett G, Stone R, Grosse W, Casas E, et al. Selection and use of SNP markers for animal identification and paternity analysis in U.S. beef cattle. Mamm Genome. 2002;13:272-81 pubmed
    ..Knowledge of these additional sites, together with the 32 target SNPs, allows the design of robust, accurate genotype assays on a variety of high-throughput SNP genotyping platforms. ..
  10. Bloch K, Wolfram J, Brown D, Roberts J, Zapol D, Lepore J, et al. Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17. Genomics. 1995;27:526-30 pubmed
    ..Clones containing three independent genes were isolated. One clone encoded the previously identified NOS II gene (NOS2A). The two other genes specified amino acids homologous, but not identical, to human NOS II (NOS2B and NOS2C)...