Gene Symbol: NFKB1
Description: nuclear factor kappa B subunit 1
Alias: nuclear factor NF-kappa-B p105 subunit, nuclear factor NF-kappa-B p105 subunit-like protein, nuclear factor of kappa light polypeptide enhancer in B-cells 1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
Roy S, Chakraborti T, Chowdhury A, Chakraborti S. Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells. J Biochem. 2013;153:289-302 pubmed publisher
Gonzalez Pacheco F, Deudero J, Castellanos M, Castilla M, Alvarez Arroyo M, Yagüe S, et al
. Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2. Am J Physiol Heart Circ Physiol. 2006;291:H1395-401 pubmed
..ROS induce expression not only of VEGF but also of VEGFR2. VEGFR2 increase by ROS is mainly driven through a NF-kappaB-dependent pathway. ..
Mazor R, Alsaigh T, Shaked H, Altshuler A, Pocock E, Kistler E, et al
. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013;288:598-607 pubmed publisher
..These results suggest a mechanism by which MMP-1 may prime or sensitize endothelial cell functions. ..
Wu J, Ding Y, Bi Y, Wang Y, Zhi Y, Wang J, et al
. Staphylococcus aureus induces TGF-Î²1 and bFGF expression through the activation of AP-1 and NF-ÎºB transcription factors in bovine mammary gland fibroblasts. Microb Pathog. 2016;95:7-14 pubmed publisher
..Taken together, S.Â aureus induces TGF-Î²1 and bFGF expression through the activation of AP-1 and NF-ÎºB in BMFBs. This information offers new potential targets for the treatment of bovine mammary fibrosis. ..
Chowdhury T, Salter D, Bader D, Lee D. Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression. Inflamm Res. 2008;57:306-13 pubmed publisher
..This experimental approach could provide valuable information for the biophysical/pharmacological treatment of OA. ..
He X, Liu W, Shi M, Yang Z, Zhang X, Gong P. Docosahexaenoic acid attenuates LPS-stimulated inflammatory response by regulating the PPAR?/NF-?B pathways in primary bovine mammary epithelial cells. Res Vet Sci. 2017;112:7-12 pubmed publisher
..In conclusion, these results indicated that DHA may attenuate LPS-stimulated inflammatory response in bMEC by suppressing NF-?B activation through a mechanism partly dependent on PPAR? activation. ..