NDUFV2

Summary

Gene Symbol: NDUFV2
Description: NADH:ubiquinone oxidoreductase core subunit V2
Alias: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial, NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa, NADH dehydrogenase flavoprotein 2, NADH dehydrogenase subunit II, NADH-ubiquinone oxidoreductase 24 kDa subunit, NADH-ubiquinone reductase 24 kDa mitochondrial
Species: cow

Top Publications

  1. Chomyn A, Lai S. cDNA of the 24 kDa subunit of the bovine respiratory chain NADH dehydrogenase: high sequence conservation in mammals and tissue-specific and growth-dependent expression. Curr Genet. 1989;16:117-26 pubmed
    ..A cross-hybridizing mRNA species of 930 nucleotides has also been observed in HeLa cells and found to be strongly growth regulated. ..
  2. Pilkington S, Walker J. Mitochondrial NADH-ubiquinone reductase: complementary DNA sequences of import precursors of the bovine and human 24-kDa subunit. Biochemistry. 1989;28:3257-64 pubmed
    ..Its DNA sequence has also been determined, and it codes for a protein that is closely related to the bovine protein.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  3. von Bahr Lindström H, Galante Y, Persson M, Jornvall H. The primary structure of subunit II of NADH dehydrogenase from bovine-heart mitochondria. Eur J Biochem. 1983;134:145-50 pubmed
    ..The polypeptide has a weak similarity to the iron-sulfur binding region of ferredoxin and has interesting but possibly insignificant similarities to parts of previously compared flavin-linked enzymes. ..
  4. Chen Y, Chen C, Zhang L, Green Church K, Zweier J. Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. J Biol Chem. 2005;280:37339-48 pubmed
  5. Ohnishi S, Shinzawa Itoh K, Ohta K, Yoshikawa S, Ohnishi T. New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): the significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals. Biochim Biophys Acta. 2010;1797:1901-9 pubmed publisher
    ..This suggests that if electron transfer was inhibited under pathological conditions, superoxide generation from the SF would be increased. ..
  6. Ohnishi S, Salerno J, Ohnishi T. Possible roles of two quinone molecules in direct and indirect proton pumps of bovine heart NADH-quinone oxidoreductase (complex I). Biochim Biophys Acta. 2010;1797:1891-3 pubmed publisher
    ..Q(Nf) and Q(Ns) together serve as (1e(-)/2e(-)) converter, for the transfer of reducing equivalent to the Q-pool. ..