Gene Symbol: MYD88
Description: myeloid differentiation primary response 88
Alias: myeloid differentiation primary response protein MyD88, myeloid differentiation factor 88, myeloid differentiation primary response gene (88)
Werling D, Piercy J, Coffey T. Expression of TOLL-like receptors (TLR) by bovine antigen-presenting cells-potential role in pathogen discrimination?. Vet Immunol Immunopathol. 2006;112:2-11 pubmed
Schaut R, McGill J, Neill J, Ridpath J, Sacco R. Bovine viral diarrhea virus type 2 in vivo infection modulates TLR4 responsiveness in differentiated myeloid cells which is associated with decreased MyD88 expression. Virus Res. 2015;208:44-55 pubmed publisher
..Modulated cytokine expression in HV BVDV2 macrophages was associated with decreased MyD88 expression, likely due to its interaction with viral NS5A...
Liu M, Wu Q, Wang M, Fu Y, Wang J. Lactobacillus rhamnosus GR-1 Limits Escherichia coli-Induced Inflammatory Responses via Attenuating MyD88-Dependent and MyD88-Independent Pathway Activation in Bovine Endometrial Epithelial Cells. Inflammation. 2016;39:1483-94 pubmed publisher
..speck-like protein, and caspase-1), TLR4 downstream adaptor molecules (myeloid differentiation antigen 88 [MyD88], toll-like receptor adaptor molecule 2 [TICAM2]), nuclear transcription factor kB (NF-kB), and the inflammatory ..
Yang W, Zerbe H, Petzl W, Brunner R, Günther J, Draing C, et al
. Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder. Mol Immunol. 2008;45:1385-97 pubmed
..proportion of this activation is attributable to TLR-mediated signalling, since a dual transdominant negative DN-MyD88-DN-TRIF factor blocks >80% of the pathogen-related NF-kappaB activation in pbMEC...
Cates E, Connor E, Mosser D, Bannerman D. Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kappaB activation and apoptosis. Comp Immunol Microbiol Infect Dis. 2009;32:477-90 pubmed publisher
..Human myeloid differentiation-factor 88 (MyD88) and TIR-domain containing adaptor protein (TIRAP) are critical proteins in the LPS-induced NF-kappaB and ..
Wang Y, Liu S, Li Y, Wang Q, Shao J, Chen Y, et al
. Mycoplasma bovis-derived lipid-associated membrane proteins activate IL-1Î² production through the NF-ÎºB pathway via toll-like receptor 2 and MyD88. Dev Comp Immunol. 2016;55:111-8 pubmed publisher
..bovis-derived LAMP-induced IL-1Î² expression. TLR2 and myeloid differentiation primary response gene 88 (MyD88) overexpression increased LAMP-dependent IL-1Î² induction...
Capparelli R, De Chiara F, Nocerino N, Medaglia C, Di Costanzo R, Ramunno L, et al
. Heterozygosity at the A625C polymorphic site of the MyD88 gene is associated with Mycobacterium bovis infection in cattle. Infect Immun. 2013;81:2139-44 pubmed publisher
The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis (odds ratio [OR] = 0.19; P = 6 × 10(-12))...