Gene Symbol: MMP14
Description: matrix metallopeptidase 14
Alias: matrix metalloproteinase-14, MMP-14, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, matrix metallopeptidase 14 (membrane-inserted), matrix metalloproteinase 14 (membrane-inserted), matrix metalloproteinase 14 preproprotein, membrane-type matrix metalloproteinase 1, membrane-type-1 matrix metalloproteinase
Langlois S, Gingras D, Beliveau R. Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. Blood. 2004;103:3020-8 pubmed
..Given the important contribution of platelets to tumor angiogenesis, the stimulation of endothelial MT1-MMP function by S1P may thus constitute an important molecular event linking hemostasis to angiogenesis. ..
Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed
De Croos J, Roughley P, Kandel R. Improved bioengineered cartilage tissue formation following cyclic compression is dependent on upregulation of MT1-MMP. J Orthop Res. 2010;28:921-7 pubmed publisher
..Further analysis of the anabolic genes and proteins involved in mechanically stimulated cartilage will lead to better understanding of the mechanism(s) underlying tissue formation yielding improved bioengineered cartilage. ..
Dilly M, Hambruch N, Shenavai S, Schuler G, Froehlich R, Haeger J, et al
. Expression of matrix metalloproteinase (MMP)-2, MMP-14 and tissue inhibitor of matrix metalloproteinase (TIMP)-2 during bovine placentation and at term with or without placental retention. Theriogenology. 2011;75:1104-14 pubmed publisher
..The presence of the activated enzyme was confirmed by zymography. In conclusion, MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle. ..
Mishra B, Kizaki K, Sato T, Ito A, Hashizume K. The role of extracellular matrix metalloproteinase inducer (EMMPRIN) in the regulation of bovine endometrial cell functions. Biol Reprod. 2012;87:149 pubmed publisher
..These results suggest that EMMPRIN derived from epithelial cells regulates MMPs in the endometrium under progesterone-rich conditions and may thereby modulate bovine endometrial cell functions during gestation...
Roy S, Chakraborti T, Chowdhury A, Chakraborti S. Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells. J Biochem. 2013;153:289-302 pubmed publisher
Sarkar J, Chowdhury A, Chakraborti T, Chakraborti S. Cross-talk between NADPH oxidase-PKCÎ±-p(38)MAPK and NF-ÎºB-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells. Mol Cell Biochem. 2016;415:13-28 pubmed publisher
..our results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCÎ±-p(38)MAPK and NFÎºB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells.
Mishra B, Kizaki K, Koshi K, Ushizawa K, Takahashi T, Hosoe M, et al
. Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and its related extracellular matrix degrading enzymes in the endometrium during estrous cycle and early gestation in cattle. Reprod Biol Endocrinol. 2010;8:60 pubmed publisher
Ulbrich S, Meyer S, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, et al
. Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy. Mol Cell Endocrinol. 2011;332:48-57 pubmed publisher
..In this study we observed distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine ..