Gene Symbol: MMP1
Description: matrix metallopeptidase 1 (interstitial collagenase)
Alias: MMP-1, interstitial collagenase, fibroblast collagenase, matrix metalloproteinase-1
Species: cow
Products:     MMP1

Top Publications

  1. Tamura M, Shimokawa H, Sasaki S. Primary structure of bovine interstitial collagenase deduced from cDNA sequence. DNA Seq. 1994;5:63-6 pubmed
    b>Interstitial collagenase (EC, MMP-1) is a member of a family of metalloproteinases and is though to play a role in extracellular matrix remodeling...
  2. Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed
  3. Mutlag A, Wang X, Yang Z, Meng J, Wang X, Zhang J, et al. Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts. Anim Reprod Sci. 2015;152:1-7 pubmed publisher
    ..The present study suggests that the abnormal expression of the MMP-1/2 gene might be an important marker of ovarian follicular cysts in dairy cows. ..
  4. Litherland G, Elias M, Hui W, Macdonald C, Catterall J, Barter M, et al. Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction. J Biol Chem. 2010;285:22414-25 pubmed publisher
    ..However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play ..
  5. Linsuwanont Santiwong B, Takagi Y, Ohya K, Shimokawa H. Expression of MT1-MMP during deciduous tooth resorption in odontoclasts. J Bone Miner Metab. 2006;24:447-53 pubmed
    ..The present identification of MT1-MMP in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface. ..
  6. Langlois S, Nyalendo C, Di Tomasso G, Labrecque L, Roghi C, Murphy G, et al. Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation. Mol Cancer Res. 2007;5:569-83 pubmed
    ..Taken together, our results suggest that the inhibition of EGFR may represent a novel target to inhibit MT1-MMP-dependent processes associated with tumor cell invasion and angiogenesis. ..
  7. van Engelen E, Breeveld Dwarkasing V, Taverne M, Everts M, van der Weijden G, Rutten V. MMP-2 expression precedes the final ripening process of the bovine cervix. Mol Reprod Dev. 2008;75:1669-77 pubmed publisher
  8. Tebaldi G, Jacca S, Montanini B, Capra E, Rosamilia A, Sala A, et al. Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells. Biol Reprod. 2016;95:12 pubmed publisher
    ..cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1) and interleukin 8 (IL8)...
  9. Sudbeck B, Jeffrey J, Welgus H, Mecham R, McCourt D, Parks W. Purification and characterization of bovine interstitial collagenase and tissue inhibitor of metalloproteinases. Arch Biochem Biophys. 1992;293:370-6 pubmed
    In this report we describe the purification of bovine interstitial collagenase and provide information on its substrate specificity, kinetic parameters of catalytic activity, and amino terminal protein sequence...

More Information


  1. Bakke L, Li Q, Cassar C, Dow M, Pursley J, Smith G. Gonadotropin surge-induced differential upregulation of collagenase-1 (MMP-1) and collagenase-3 (MMP-13) mRNA and protein in bovine preovulatory follicles. Biol Reprod. 2004;71:605-12 pubmed
    ..base) for the preovulatory collagenolysis required for follicle rupture. ..
  2. Ohta Y, Hayashi M, Kanemaru T, Abe K, Ito Y, Oike M. Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production. J Immunol. 2008;180:4191-9 pubmed
    ..This indicates that Th2 cytokines modulate airway contraction without affecting cellular contractility but by secreting MMP-1 from the SM cells via PI3K activation and changing cell-to-matrix interactions. ..
  3. Zhang B, Yan L, Moses M, Tsang P. Bovine membrane-type 1 matrix metalloproteinase: molecular cloning and expression in the corpus luteum. Biol Reprod. 2002;67:99-106 pubmed
    ..Taken together, the differential expression and localization of MT1-MMP in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle, including activation of pro-MMP-2. ..
  4. Abe H, Sakumoto R, Okuda K. Expression of matrix metalloproteinases in bovine luteal cells induced by prostaglandin F2α, interferon γ and tumor necrosis factor α. J Reprod Dev. 2015;61:277-86 pubmed publisher
  5. Mazor R, Alsaigh T, Shaked H, Altshuler A, Pocock E, Kistler E, et al. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013;288:598-607 pubmed publisher
    ..These results suggest a mechanism by which MMP-1 may prime or sensitize endothelial cell functions. ..
  6. Maeda E, Sugimoto M, Ohashi T. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates. J Biomech. 2013;46:991-7 pubmed publisher
    ..On the other hand, tenocyte anabolism, as measured by type I collagen mRNA expression, was not altered with substrate stiffness. ..
  7. Qi Y, Zhang X, Wang Y, Pang Y, Zhang Z, Zhang T, et al. Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle. Genet Mol Res. 2016;15:15017593 pubmed publisher
    ..This study indicates that the remodeling of the ECM has important effects both on the development of postnatal skeletal muscle and on meat quality. ..
  8. Christison K, Schmutz S, Berryere T, Buchanan F. Linkage mapping of MMP1 to cattle chromosome 15. Anim Genet. 2001;32:316 pubmed