matrix metalloproteinase 13
Gene Symbol: matrix metalloproteinase 13
Description: matrix metallopeptidase 13
Alias: collagenase 3, MMP-13, matrix metalloproteinase 13 (collagenase 3), matrix metalloproteinase-13
Flannery C, Little C, Caterson B, Hughes C. Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes. Matrix Biol. 1999;18:225-37 pubmed
Heathfield T, Onnerfjord P, Dahlberg L, Heinegard D. Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13. J Biol Chem. 2004;279:6286-95 pubmed
Bakke L, Li Q, Cassar C, Dow M, Pursley J, Smith G. Gonadotropin surge-induced differential upregulation of collagenase-1 (MMP-1) and collagenase-3 (MMP-13) mRNA and protein in bovine preovulatory follicles. Biol Reprod. 2004;71:605-12 pubmed
..base) for the preovulatory collagenolysis required for follicle rupture. ..
Wu C, Tchetina E, Mwale F, Hasty K, Pidoux I, Reiner A, et al
. Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization. J Bone Miner Res. 2002;17:639-51 pubmed
..These results suggest that proteolysis involving MMP-13 is required for chondrocyte differentiation that occurs as part of growth plate development and which is associated with matrix mineralization. ..
Litherland G, Elias M, Hui W, Macdonald C, Catterall J, Barter M, et al
. Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction. J Biol Chem. 2010;285:22414-25 pubmed publisher
..aPKCs may constitute potential therapeutic targets for inflammatory joint diseases involving increased collagenase expression. ..
Ohno S, Im H, Knudson C, Knudson W. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. J Biol Chem. 2006;281:17952-60 pubmed
..Our findings suggest that hyaluronan-CD44 interactions affect matrix metabolism via activation of NFkappaB and p38 MAP kinase. ..
Tchetina E, Kobayashi M, Yasuda T, Meijers T, Pidoux I, Poole A. Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis. Matrix Biol. 2007;26:247-58 pubmed
..This response of the chondrocyte to a cryptic sequence of denatured type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis. ..
Nakagawa K, Teramura T, Takehara T, Onodera Y, Hamanishi C, Akagi M, et al
. Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants. Inflamm Res. 2012;61:1093-100 pubmed publisher
Balcerzak D, Querengesser L, Dixon W, Baracos V. Coordinate expression of matrix-degrading proteinases and their activators and inhibitors in bovine skeletal muscle. J Anim Sci. 2001;79:94-107 pubmed