LTF

Summary

Gene Symbol: LTF
Description: lactotransferrin
Alias: lactotransferrin, lactoferrin
Species: cow

Top Publications

  1. ncbi Bovine lactoferrin mRNA: sequence, analysis, and expression in the mammary gland
    R E Goodman
    J A Baker Institute, Cornell University, Ithaca, New York 14853
    Biochem Biophys Res Commun 180:75-84. 1991
  2. ncbi New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors
    A Ohashi
    Institute for Health Sciences, Tokushima Bunri University, Yamashiro cho, 770 8514, Tokushima City, Japan
    Biochem Biophys Res Commun 306:98-103. 2003
  3. ncbi Role of endogenous interferon and LPS in the immunomodulatory effects of bovine lactoferrin in murine peritoneal macrophages
    Patrizia Puddu
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Leukoc Biol 82:347-53. 2007
  4. ncbi Identification of the bactericidal domain of lactoferrin
    W Bellamy
    Nutritional Science Laboratory, Morinaga Milk Industry Company Limited, Zama City, Japan
    Biochim Biophys Acta 1121:130-6. 1992
  5. doi Polymorphisms in the promoter region of the bovine lactoferrin gene influence milk somatic cell score and milk production traits in Chinese Holstein cows
    Yongjiang Mao
    College of Animal Science and Technology, Yangzhou University, 225009 Yangzhou, PR China College of Animal Science and Technology, Huazhong Agricultural University, 430070 Wuhan, PR China Electronic address
    Res Vet Sci 103:107-12. 2015
  6. doi Effects of induced energy deficiency on lactoferrin concentration in milk and the lactoferrin reaction of primary bovine mammary epithelial cells in vitro
    K Danowski
    Physiology Weihenstephan, Technische Universitat Munchen, Freising Weihenstephan, Germany
    J Anim Physiol Anim Nutr (Berl) 97:647-55. 2013
  7. ncbi Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1
    Thai Yen Ling
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 279:38736-48. 2004
  8. ncbi Crystal structure of a proteolytically generated functional monoferric C-lobe of bovine lactoferrin at 1.9A resolution
    Sujata Sharma
    Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Mol Biol 331:485-96. 2003
  9. pmc Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage
    Dongyao Yan
    From the Departments of Biochemistry
    J Biol Chem 288:31655-69. 2013
  10. pmc Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts
    Jian Ming Hou
    1 Fujian Provincial Hospital, Fuzhou 350001, China 2 Provincial Clinical Medical College of Fujian Medical University, Fuzhou 350004, China
    Acta Pharmacol Sin 35:523-30. 2014

Scientific Experts

  • Jillian Cornish
  • Denise Greathouse
  • Yongjiang Mao
  • M Murata
  • Katarzyna Wojdak-Maksymiec
  • K S Hoek
  • M G Ammendolia
  • Morshedur Rahman
  • Chiara Pecorini
  • Björn A Persson
  • M Fasano
  • Akihito Tsubota
  • Romy Fischer
  • Takahiko Oho
  • Sujata Sharma
  • F O'Halloran
  • Rafia Mir
  • Patrizia Puddu
  • Dongyao Yan
  • Tej P Singh
  • Piera Valenti
  • Michał Zimecki
  • Asha Bhushan
  • Nagendra Singh
  • Ivonne Maciel Arciniega-Martinez
  • Jian Ming Hou
  • Ewa Zaczynska
  • Hemalatha Jegasothy
  • Guozhi Xiao
  • Tomoji Ono
  • K Danowski
  • Isui García-Montoya
  • Jae Sung Kim
  • Hee Jeong Im
  • Ranjan Kc
  • Di Chen
  • Toshihiro Inubushi
  • Pengcheng Wen
  • Sander S van Leeuwen
  • P Valenti
  • Shinichi Saito
  • Arnaud Malet
  • Meng Hsiu Yen
  • Patrick S Günther
  • Maja Kocieba
  • Nina Zemann
  • Xuejing Bai
  • Jinming Huang
  • Ioanna Mela
  • Nobuhisa Sasaki
  • Alagiri Srinivasan
  • Punit Kaur
  • Huiyuan Guo
  • B Bahar
  • T Sweeney
  • L Giblin
  • Gopalakrishnapillai Vikram
  • Mau Sinha
  • Fazheng Ren
  • Aaron P Yamniuk
  • V M R Arnould
  • Sandra Gessani
  • Hong Mei Wang
  • Songtao Li
  • Yu Jung Chien
  • Vittoria Buccigrossi
  • Hongxia Luo
  • Yumiko Komine
  • Talat Jabeen
  • Jiamao Zheng
  • Thai Yen Ling
  • Maria Teresa Massucci
  • Francesca Berlutti
  • Giovanni Antonini
  • Aldo Arturo Reséndiz-Albor
  • Akito Nozaki
  • T Kutila
  • Maria Elisa Drago-Serrano
  • Rafael Campos-Rodríguez
  • Luvia Enid Sánchez-Torres
  • Teresita Rocío Cruz-Hernández
  • A Ohashi
  • Fan Lin
  • Man Wu
  • Ewelina Śliwińska
  • Xu Hua Lan
  • En Yu Chen
  • Louise E Bennett
  • Qing Ming Lin
  • Ying Xue

Detail Information

Publications71

  1. ncbi Bovine lactoferrin mRNA: sequence, analysis, and expression in the mammary gland
    R E Goodman
    J A Baker Institute, Cornell University, Ithaca, New York 14853
    Biochem Biophys Res Commun 180:75-84. 1991
    The mRNA sequence for bovine lactoferrin expressed in the mammary gland was determined by sequencing three over lapping cDNA clones and by direct sequencing of the mRNA...
  2. ncbi New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors
    A Ohashi
    Institute for Health Sciences, Tokushima Bunri University, Yamashiro cho, 770 8514, Tokushima City, Japan
    Biochem Biophys Res Commun 306:98-103. 2003
    We found new inhibitory function of lactoferrin and beta-casein in milk against cysteine proteases using reverse zymography...
  3. ncbi Role of endogenous interferon and LPS in the immunomodulatory effects of bovine lactoferrin in murine peritoneal macrophages
    Patrizia Puddu
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Leukoc Biol 82:347-53. 2007
    b>Lactoferrin (Lf) plays an important role in host defense against infection and excessive inflammation...
  4. ncbi Identification of the bactericidal domain of lactoferrin
    W Bellamy
    Nutritional Science Laboratory, Morinaga Milk Industry Company Limited, Zama City, Japan
    Biochim Biophys Acta 1121:130-6. 1992
    We report the existence of a previously unknown antimicrobial domain near the N-terminus of lactoferrin in a region distinct from its iron-binding sites...
  5. doi Polymorphisms in the promoter region of the bovine lactoferrin gene influence milk somatic cell score and milk production traits in Chinese Holstein cows
    Yongjiang Mao
    College of Animal Science and Technology, Yangzhou University, 225009 Yangzhou, PR China College of Animal Science and Technology, Huazhong Agricultural University, 430070 Wuhan, PR China Electronic address
    Res Vet Sci 103:107-12. 2015
    b>Lactoferrin is an iron-binding protein found in cow's milk that plays an important role in preventing mastitis caused by intramammary infection...
  6. doi Effects of induced energy deficiency on lactoferrin concentration in milk and the lactoferrin reaction of primary bovine mammary epithelial cells in vitro
    K Danowski
    Physiology Weihenstephan, Technische Universitat Munchen, Freising Weihenstephan, Germany
    J Anim Physiol Anim Nutr (Berl) 97:647-55. 2013
    ..coli) and Staphylococcus aureus (S. aureus) was conducted. Lactoferrin (LF) was determined on gene expression and protein level...
  7. ncbi Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1
    Thai Yen Ling
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 279:38736-48. 2004
    ..These results suggest that cell surface annexin VI may function as an acidic pH binding site or receptor and may also function as a co-receptor with LRP-1 at neutral pH...
  8. ncbi Crystal structure of a proteolytically generated functional monoferric C-lobe of bovine lactoferrin at 1.9A resolution
    Sujata Sharma
    Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Mol Biol 331:485-96. 2003
    This is the first crystal structure of a proteolytically generated functional C-lobe of lactoferrin. The purified samples of iron-saturated C-lobe were crystallized in 0.1 M Mes buffer (pH 6...
  9. pmc Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage
    Dongyao Yan
    From the Departments of Biochemistry
    J Biol Chem 288:31655-69. 2013
    ..Together, our results suggest a two-step mechanism, whereby LfcinB induces TIMP-1 through an IL-11-dependent pathway involving transcription factor AP-1 and STAT3. ..
  10. pmc Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts
    Jian Ming Hou
    1 Fujian Provincial Hospital, Fuzhou 350001, China 2 Provincial Clinical Medical College of Fujian Medical University, Fuzhou 350004, China
    Acta Pharmacol Sin 35:523-30. 2014
    Excessive apoptosis of osteoblasts is the major cause of low bone mass, and bovine lactoferrin (bLF), an iron-binding glycoprotein, might protect osteoblastic cells from apoptosis induced by serum withdrawal...
  11. pmc Hepatitis C virus envelope proteins bind lactoferrin
    M Yi
    Department of Molecular Biology, Medical School, Kanazawa University, Takara machi, Japan
    J Virol 71:5997-6002. 1997
    ..Here we report that human as well as bovine lactoferrin, a multifunctional immunomodulator, binds two HCV envelope proteins...
  12. doi In vitro heme and non-heme iron capture from hemoglobin, myoglobin and ferritin by bovine lactoferrin and implications for suppression of reactive oxygen species in vivo
    Hemalatha Jegasothy
    CSIRO Food, Nutrition and Bioproducts, Private Bag 16, 671 Sneydes Road, Werribee, Vic, 3030, Australia
    Biometals 27:1371-82. 2014
    b>Lactoferrin (Lf), present in colostrum and milk is a member of the transferrin family of iron-binding glyco-proteins, with stronger binding capacity to ferric iron than hemoglobin, myoglobin or transferrin...
  13. doi Bovine lactoferrin enhances proliferation of human peripheral blood lymphocytes and induces cytokine production in whole blood cultures
    Ewa Zaczynska
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wrocław, Poland
    Adv Clin Exp Med 23:871-6. 2014
    b>Lactoferrin belongs to the immunoregulatory milk proteins involved in iron metabolism as well in providing innate immunity to newborns. The protein has been the subject of numerous clinical studies.
  14. doi Modulatory Effects of Oral Bovine Lactoferrin on the IgA Response at Inductor and Effector Sites of Distal Small Intestine from BALB/c Mice
    Ivonne Maciel Arciniega-Martinez
    Research and Graduate Studies Section, Superior School of Medicine, National Polytechnic Institute, Plan de San Luis y Díaz Mirón s n, Col Santo Tomas, CP 11340, Mexico, DF, Mexico
    Arch Immunol Ther Exp (Warsz) 64:57-63. 2016
    Bovine lactoferrin (bLf) up-modulates intestinal IgA that is essential for homeostasis and which might confer protection to the distal small intestine that is vulnerable to inflammation...
  15. pmc Parity-dependent association between TNF-α and LTF gene polymorphisms and clinical mastitis in dairy cattle
    Katarzyna Wojdak-Maksymiec
    Faculty of Biotechnology and Husbandry, Department of Animal Genetics and Breeding, West Pomeranian University of Technology in Szczecin, ul, Doktora Judyma 6, Szczecin, Poland
    BMC Vet Res 9:114. 2013
    ..We proposed tumor necrosis factor α (TNF-α), lactoferrin (LTF) and macrophage-expressed lysozyme (mLYZ) genes as potential DNA markers in the improvement of immunity to ..
  16. ncbi Anti-nociceptive effect of bovine milk-derived lactoferrin in a rat lumbar disc herniation model
    Nobuhisa Sasaki
    Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
    Spine (Phila Pa 1976) 35:1663-7. 2010
    ..An experimental animal study...
  17. ncbi Lactoferrin decreases inflammatory response by cystic fibrosis bronchial cells invaded with Burkholderia cenocepacia iron-modulated biofilm
    P Valenti
    Department of Public Health and Infectious Disease, Sapienza University of Rome, Italy
    Int J Immunopathol Pharmacol 24:1057-68. 2011
    ..b>Lactoferrin (Lf), an iron binding multifunctional glycoprotein synthesized by exocrine glands and neutrophils, has been ..
  18. doi Use of Wisteria floribunda agglutinin affinity chromatography in the structural analysis of the bovine lactoferrin N-linked glycosylation
    Sander S van Leeuwen
    Department of Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Nijenborgh 7, NL 9747 AG Groningen, The Netherlands
    Biochim Biophys Acta 1820:1444-55. 2012
    Over the years, the N-glycosylation of both human and bovine lactoferrin (LF) has been studied extensively, however not all aspects have been studied in as much detail...
  19. doi Effect of glucose on the lactoferrin's conformation and its effect on MC 3T3-E1 cell proliferation
    Pengcheng Wen
    College of Food Science and Engineering, Gansu Agricultural University, Lanzhou, China
    Protein J 31:300-5. 2012
    The objective of this research was to investigate the influence of glucose on bovine lactoferrin's (LF) conformation, thermodynamic stability and osteoblastic cell proliferation...
  20. pmc Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc
    Jae Sung Kim
    Section of Rheumatology, Department of Biochemistry, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Cell Physiol 228:1884-96. 2013
    ....
  21. pmc Molecular mechanisms of the inhibitory effects of bovine lactoferrin on lipopolysaccharide-mediated osteoclastogenesis
    Toshihiro Inubushi
    Department of Oral and Maxillofacial Pathobiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    J Biol Chem 287:23527-36. 2012
    b>Lactoferrin (LF) is an important modulator of the immune response and inflammation. It has also been implicated in the regulation of bone tissue...
  22. ncbi Potent lipolytic activity of lactoferrin in mature adipocytes
    Tomoji Ono
    Research and Development Headquarters, Lion Corporation, Odawara, Kanagawa, Japan
    Biosci Biotechnol Biochem 77:566-71. 2013
    b>Lactoferrin (LF) is a multifunctional glycoprotein found in mammalian milk. We have shown in a previous clinical study that enteric-coated bovine LF tablets decreased visceral fat accumulation...
  23. doi Expression and characterization of recombinant bovine lactoferrin in E. coli
    Isui García-Montoya
    Laboratorio de Biotecnologia, Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Circuito 1, Nuevo Campus Universitario, 31125, Chihuahua, Mexico
    Biometals 26:113-22. 2013
    b>Lactoferrin is a member of the transferrin family of iron-binding proteins with a number of properties, including antibacterial activity against a broad spectrum of Gram-negative and Gram-positive bacteria...
  24. doi Single nucleotide polymorphisms, haplotypes and combined genotypes of lactoferrin gene and their associations with mastitis in Chinese Holstein cattle
    Jinming Huang
    Center of Dairy Cattle Research, Shandong Academy of Agricultural Science, Jinan, People s Republic of China
    Mol Biol Rep 37:477-83. 2010
    b>Lactoferrin (Lf) is naturally produced by the mammary gland, having biological functions of antibacterial and anti-inflammatory activities...
  25. pmc The structural basis for the prevention of nonsteroidal antiinflammatory drug-induced gastrointestinal tract damage by the C-lobe of bovine colostrum lactoferrin
    Rafia Mir
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
    Biophys J 97:3178-86. 2009
    ..It was found that the addition of C-terminal half of bovine lactoferrin (C-lobe) reversed the NSAID-induced injuries to the extent of 47-70% whereas the coadministration of C-lobe ..
  26. doi Contribution of bovine lactoferrin inter-lobe region to iron binding stability and antimicrobial activity against Staphylococcus aureus
    Xuejing Bai
    Key Laboratory of Feed Biotechnology, Ministry of Agriculture, 100081 Beijing, People s Republic of China
    Biometals 23:431-9. 2010
    The investigation of the recombinant bovine lactoferrin-derived antimicrobial protein (rBLfA) demonstrates that the inter-lobe region of bovine lactoferrin contributes to iron binding stability and antimicrobial activity against ..
  27. doi Polymorphisms in the bovine lactoferrin promoter are associated with reproductive performance and somatic cell count
    F O'Halloran
    Teagasc, Moorepark Food Research Centre, Fermoy, Co Cork, Ireland
    J Dairy Sci 93:1253-9. 2010
    b>Lactoferrin plays an important role in the innate immune system, with well-characterized antibacterial, antiviral, and immune modulatory properties...
  28. doi Charge reversal by salt-induced aggregation in aqueous lactoferrin solutions
    Ioanna Mela
    Unilever Discover, Colworth Science Park, Sharnbrook, Bedford, UK
    Colloids Surf B Biointerfaces 78:53-60. 2010
    We have observed salt-induced aggregation in lactoferrin solutions using dynamic light scattering (DLS). Aggregates start to form once the ionic strength exceeds 10 mM, and are of opposite charge to their monomer building blocks...
  29. doi Lactoferrin induces growth arrest and nuclear accumulation of Smad-2 in HeLa cells
    Nina Zemann
    Medical University of Vienna, Centre for Pathobiochemistry and Genetic, Inst Med Chem, Waehringerstr 10 13, A 1090 Vienna, Austria
    Biochimie 92:880-4. 2010
    b>Lactoferrin (Lf) is a multifunctional glycoprotein. Due to its anti-inflammatory and anti-cancer properties and the resulting therapeutical potential, lactoferrin is at present focus of a variety of research areas...
  30. doi Evaluation of the protective effect of bovine lactoferrin against lipopolysaccharides in a bovine mammary epithelial cell line
    Chiara Pecorini
    Dipartimento di Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Universita degli Studi di Milano, Via Celoria 10, Milan, Italy
    Vet Res Commun 34:267-76. 2010
    b>Lactoferrin (Lf) is a non-haem iron-binding glycoprotein with a molecular weight of about 80 kDa, synthesized by glandular epithelial cells and stored in the secondary granules of neutrophils...
  31. doi Bovine lactoferrin interacts with cable pili of Burkholderia cenocepacia
    Maria Grazia Ammendolia
    Department of Technology and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biometals 23:531-42. 2010
    In this study we evaluated the ability of lactoferrin, the most abundant antimicrobial protein in airway secretions, to bind the surface structures of a Burkholderia strain cystic fibrosis-isolated...
  32. doi Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs)
    Rafia Mir
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India
    Arch Biochem Biophys 500:196-202. 2010
    ..In order to minimize these side effects, C-terminal half (C-lobe) of colostrum protein lactoferrin has been indicated to be useful if co-administered with NSAIDs...
  33. doi Molecular evidence of stereo-specific lactoferrin dimers in solution
    Björn A Persson
    Department of Theoretical Chemistry, Lund University, Sweden
    Biophys Chem 151:187-9. 2010
    Gathering experimental evidence suggests that bovine as well as human lactoferrin self-associate in aqueous solution. Still, a molecular level explanation is unavailable...
  34. doi Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts
    Shinichi Saito
    Functional Biomolecules Research Team, National Institute of Livestock and Grassland Science, 2 Ikenodai, Tsukuba, Ibaraki, 305 0901, Japan
    Biotechnol Lett 33:33-9. 2011
    Bovine lactoferrin (BLF) enhanced production of hyaluronan in normal human dermal fibroblasts. The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression...
  35. doi Recognition roles of the carbohydrate glycotopes of human and bovine lactoferrins in lectin-N-glycan interactions
    Meng Hsiu Yen
    Glyco Immunochemistry Research Labortory, Institute of Molecular and Cellular Biology, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
    Biochim Biophys Acta 1810:139-49. 2011
    b>Lactoferrin is an iron-binding protein belonging to the transferrin family. In addition to iron homeostasis, lactoferrin is also thought to have anti-microbial, anti-inflammatory, and anticancer activities...
  36. doi Bovine lactoferrin improves bone status of ovariectomized mice via immune function modulation
    Arnaud Malet
    AgroParisTech, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France
    Bone 48:1028-35. 2011
    We have previously shown that bovine lactoferrin (bLF) supplementation can have a beneficial effect on postmenopausal bone loss by modulating bone formation and resorption...
  37. doi CD209/DC-SIGN mediates efficient infection of monocyte-derived dendritic cells by clinical adenovirus 2C isolates in the presence of bovine lactoferrin
    Patrick S Günther
    Institut für Medizinische Virologie und Epidemiologie der Viruserkrankungen, Universitatsklinikum Tubingen, 72076 Tubingen, Germany
    J Gen Virol 92:1754-9. 2011
    ..We show that the antiviral protein bovine lactoferrin enhances infection of monocyte-derived dendritic cells (MDDC) by adenovirus species C serotype 2 (2C) isolates...
  38. pmc Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells
    Patrizia Puddu
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 6:e22504. 2011
    b>Lactoferrin (LF), a key element in mammalian immune system, plays pivotal roles in host defence against infection and excessive inflammation...
  39. doi Bovine lactoferrin region responsible for binding to bifidobacterial cell surface proteins
    Morshedur Rahman
    Laboratory of Dairy Food Science, Research Faculty of Agriculture, Hokkaido University, W 9, N 9, Sapporo 060 8589, Japan
    Biotechnol Lett 31:863-8. 2009
    Bovine lactoferrin promotes bifidobacterial growth. Its binding to bifidobacteria is thought to be responsible for such action...
  40. ncbi Consistency of SINE insertion topology and flanking sequence tree: quantifying relationships among cetartiodactyls
    J K Lum
    Institute of Statistical Mathematics, Tokyo, Japan Tokyo Institute of Technology, Yokohama, Japan
    Mol Biol Evol 17:1417-24. 2000
    ..Sequence simulations suggest that this rate heterogeneity may be an artifact resulting from the inaccuracies of the substitution model used...
  41. ncbi 1H NMR relaxometric characterization of bovine lactoferrin
    Mauro Fasano
    Dipartimento di Biologia Strutturale e Funzionale, Universita dell Insubria, Via Alberto da Giussano 12, I 21052 Busto Arsizio VA, Italy
    J Inorg Biochem 98:1421-6. 2004
    b>Lactoferrin (Lf) is a mammalian iron binding protein present in external secretions and in polymorphonuclear leukocytes. Its role in host defense mechanisms related to the non-immune defense system has been definitively established...
  42. ncbi Lactoferrin promotes bone growth
    J Cornish
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biometals 17:331-5. 2004
    We have demonstrated bovine or human lactoferrin to be an anabolic factor in skeletal tissue...
  43. ncbi Both lactoferrin and iron influence aggregation and biofilm formation in Streptococcus mutans
    Francesca Berlutti
    Department of Public Health Sciences, University of Rome La Sapienza, Italy
    Biometals 17:271-8. 2004
    ..that trace metals, including iron, can be associated with dental caries, the function of salivary iron and lactoferrin in the human oral cavity remains unclear...
  44. ncbi Proteolytic activity of bovine lactoferrin
    Maria Teresa Massucci
    Dipartimento di Biologia di Base ed Applicata, Universita di L Aquila, Coppito, 67010, L Aquila, Italy
    Biometals 17:249-55. 2004
    Bovine lactoferrin catalyzes the hydrolysis of synthetic substrates (i.e., Z-aminoacyl-7-amido-4-methylcoumarin)...
  45. ncbi Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo
    Jillian Cornish
    Department of Medicine, University of Auckland, Private Bag 92019, Auckland 1001, New Zealand
    Endocrinology 145:4366-74. 2004
    b>Lactoferrin is an iron-binding glycoprotein present in epithelial secretions, such as milk, and in the secondary granules of neutrophils...
  46. pmc Antibacterial effect of bovine lactoferrin against udder pathogens
    T Kutila
    Faculty of Veterinary Medicine, Department of Clinical Veterinary Science, University of Helsinki, Sweden
    Acta Vet Scand 44:35-42. 2003
    The antibacterial effect of lactoferrin (Lf) was tested on isolates of Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and coagulase-negative staphylococci (CNS) as well as on Pseudomonas aeruginosa (P...
  47. ncbi Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein
    Akito Nozaki
    Department of Molecular Biology, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Biol Chem 278:10162-73. 2003
    ..These results led us to consider the development of an effective anti-HCV peptide. This is the first identification of a natural protein-derived peptide that specifically binds to HCV E2 protein and prevents HCV infection...
  48. pmc A peptide domain of bovine milk lactoferrin inhibits the interaction between streptococcal surface protein antigen and a salivary agglutinin peptide domain
    Takahiko Oho
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Sciences, Fukuoka, Japan
    Infect Immun 72:6181-4. 2004
    ..responsible for its interaction with cell surface protein antigen (PAc) of Streptococcus mutans or bovine lactoferrin was found in the same peptide, scavenger receptor cysteine-rich domain peptide 2 (SRCRP2)...
  49. ncbi Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin
    P M Hwang
    Department of Biological Sciences, University of Calgary, Alberta, Canada
    Biochemistry 37:4288-98. 1998
    ..LfcinB is a 25-residue antimicrobial peptide released by pepsin cleavage of lactoferrin, an 80 kDa iron-binding glycoprotein with many immunologically important functions...
  50. ncbi Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolution
    S A Moore
    Department of Biochemistry, Massey University, Palmerston North, New Zealand
    J Mol Biol 274:222-36. 1997
    The three-dimensional structure of diferric bovine lactoferrin (bLf) has been determined by X-ray crystallography in order to investigate the factors that influence iron binding and release by transferrins...
  51. pmc Antibacterial activity in bovine lactoferrin-derived peptides
    K S Hoek
    Centre for Food Technology, Department of Primary Industries Queensland, Hamilton, Australia
    Antimicrob Agents Chemother 41:54-9. 1997
    Several peptides sharing high sequence homology with lactoferricin B (Lf-cin B) were generated from bovine lactoferrin (Lf) with recombinant chymosin...
  52. ncbi Structure of the bovine lactoferrin-encoding gene and its promoter
    H M Seyfert
    Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Dummerstorf, Germany
    Gene 143:265-9. 1994
    b>Lactoferrin (Lf), a ferric ion (Fe3+)-binding glycoprotein, is found most notably in milk, probably to mediate protection against microbial infection of the mammary gland...
  53. pmc cDNA and protein sequence of bovine lactoferrin
    P E Mead
    Department of Chemistry and Biochemistry, Massey University, Palmerston North, New Zealand
    Nucleic Acids Res 18:7167. 1990
  54. ncbi Molecular cloning and sequence analysis of bovine lactotransferrin
    A Pierce
    Laboratoire de Chimie Biologique Unité Mixte de Recherche no 111 du Centre National de la Recherche Scientifique, Université des Sciences et Techniques de Lille Flandres Artois, Villeneuve d Ascq, France
    Eur J Biochem 196:177-84. 1991
    The screening of a bovine submaxillary gland cDNA library yielded 25 clones coding for bovine lactotransferrin. The nucleotide sequence of the longest insert contained a protein-coding region of 2115 nucleotides and a 3' non-coding region ..
  55. ncbi [Genetic polymorphism in 5'-flanking region of the lactoferrin gene and its associations with mastitis in Chinese Holstein cows]
    Hong Mei Wang
    Dairy Cattle Center of Shandong Academy of Agricultural Sciences, Jinan 250100, China
    Yi Chuan 31:393-9. 2009
    Bovine lactoferrin (LF) is a multifunctional glycoprotein found in milk, which acts mainly as a defense factor in the mammary gland. Polymorphism has been found in the bovine LF gene...
  56. ncbi Characterization of the infection-responsive bovine lactoferrin promoter
    Jiamao Zheng
    Lactation and Mammary Gland Biology Group, Department of Animal Science, 213 Terrill Hall, University of Vermont, Burlington, VT 05405, USA
    Gene 353:107-17. 2005
    The concentration of lactoferrin in bovine milk is dramatically increased in response to infection. The high levels of lactoferrin may have a role in the prevention of microbial infection of the mammary gland...
  57. ncbi Structure of the zinc-saturated C-terminal lobe of bovine lactoferrin at 2.0 A resolution
    Talat Jabeen
    Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110 029, India
    Acta Crystallogr D Biol Crystallogr 61:1107-15. 2005
    The crystal structure of the zinc-saturated C-terminal lobe of bovine lactoferrin has been determined at 2.0 A resolution using crystals stabilized at pH 3.8...
  58. ncbi Inflammatory effect of cleaved bovine lactoferrin by elastase on staphylococcal mastitis
    Yumiko Komine
    Intelligent Cosmos Research Institute Corporation, Sendia, Japan
    J Vet Med Sci 68:715-23. 2006
    Elastase activity and concanavalin A (Con A) low affinity bovine lactoferrin (bLf) molecule were detected in mammary gland secretions (MGSs) from mammary glands (MGs) with clinical staphylococcal mastitis...
  59. ncbi Lactoferrin and bone; structure-activity relationships
    J Cornish
    Department of Medicine, University of Auckland, Private Bag 92019 Auckland, New Zealand
    Biochem Cell Biol 84:297-302. 2006
    ..We have previously shown that lactoferrin can promote bone growth...
  60. ncbi Regulation of physiological and pathological Th1 and Th2 responses by lactoferrin
    Romy Fischer
    Unité INRA 914 Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris Grignon, F75231 Paris Cedex 05, France
    Biochem Cell Biol 84:303-11. 2006
    ..Finally, Lf may provide protection against Th1- or Th2-induced diseases, such as autoimmune or allergic diseases, through correction of the Th1/Th2 imbalance...
  61. ncbi Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats
    Michał Zimecki
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53 114 Wrocław, Poland
    J Neuroimmunol 182:160-6. 2007
    b>Lactoferrin (LF) is a multifunctional protein present in secretory fluids of mammals and circulating neutrophils. Beside anti-inflammatory properties, LF was found to inhibit some autoimmune disorders...
  62. ncbi In vitro reconstitution of antimicrobial pathogen activity by expressed recombinant bovine lactoferrin N-terminal peptide in Escherichia coli
    Hongxia Luo
    Key Lab of Functional Dairy Science of Beijing and Ministry of Education of China, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China 100083
    J Dairy Res 74:233-8. 2007
    Recombinant bovine lactoferrin N-terminal polypeptide (rbLF-N) Escherichia coli expression system was constructed and the rbLF-N antimicrobial activity was displayed by enzymatic proteolysis in this study...
  63. ncbi Lactoferrin induces concentration-dependent functional modulation of intestinal proliferation and differentiation
    Vittoria Buccigrossi
    Department of Pediatrics, University of Naples Federico II, Naples, Utaly
    Pediatr Res 61:410-4. 2007
    Human milk stimulates intestinal development through the effects of various moieties. Lactoferrin (LF) is a glycoprotein of human milk whose concentration is highest in colostrum decreasing in mature milk...
  64. doi Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats
    Akihito Tsubota
    Institute of Clinical Medicine and Research ICMR, Jikei University School of Medicine, Kashiwa, Chiba, Japan
    J Hepatol 48:486-93. 2008
    To assess the effect of lactoferrin on oxidative liver damage and its mechanism, we used Long-Evans Cinnamon (LEC) rats that spontaneously develop fulminant-like hepatitis and lethal hepatic failure.
  65. doi Lipid interactions of acylated tryptophan-methylated lactoferricin peptides by solid-state NMR
    Denise Greathouse
    Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, USA
    J Pept Sci 14:1103-10. 2008
    ..LfB) is a 25-residue innate immunity peptide released by pepsin from the N-terminal region of bovine lactoferrin. A smaller amidated peptide, LfB6 (RRWQWR-NH2) retains antimicrobial activity and is thought to constitute the "..
  66. doi Characterisation of single nucleotide polymorphisms identified in the bovine lactoferrin gene sequences across a range of dairy cow breeds
    F O'Halloran
    Teagasc, Moorepark Food Research Centre, Fermoy, Co Cork, Ireland
    Biochimie 91:68-75. 2009
    The lactoferrin gene sequences of 70 unrelated dairy cows representing six different dairy breeds were investigated for single nucleotide polymorphisms to establish a baseline of polymorphisms that exist within the Irish bovine ..
  67. doi Bovine lactoferrin inhibits Japanese encephalitis virus by binding to heparan sulfate and receptor for low density lipoprotein
    Yu Jung Chien
    Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Virology 379:143-51. 2008
    b>Lactoferrin is a natural anti-microbial protein which affects Japanese encephalitis virus (JEV) activity...
  68. doi Inhibition of HBV infection by bovine lactoferrin and iron-, zinc-saturated lactoferrin
    Songtao Li
    Northeast Agricultural University, 150030, Harbin, Heilongjiang, China
    Med Microbiol Immunol 198:19-25. 2009
    In this study, we investigated the effect of bovine lactoferrin (BLf), lactoferrin hydrolysate, or iron-, zinc-saturated lactoferrin on hepatitis B virus (HBV)-infected HepG2 cells...
  69. doi Genetic analysis of lactoferrin content in bovine milk
    V M R Arnould
    Animal and Microbial Biology Unit, Gembloux Agricultural University, B 5030 Gembloux, Belgium
    J Dairy Sci 92:2151-8. 2009
    Bovine lactoferrin (LF) is mainly present in milk and shows important physiological and biological functions...
  70. doi Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin
    Aaron P Yamniuk
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada
    Mol Immunol 46:2395-402. 2009
    The immunoregulatory proteins osteopontin (OPN) and lactoferrin (LF) are both highly abundant in milk, with a conserved ratio between different mammalian species, suggesting that the role of each protein in infant development may be ..