Gene Symbol: LOX
Description: lysyl oxidase
Alias: protein-lysine 6-oxidase
Trackman P, Pratt A, Wolanski A, Tang S, Offner G, Troxler R, et al
. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Biochemistry. 1990;29:4863-70 pubmed
..A 258-bp segment of the 3'-untranslated region of lysyl oxidase cDNA is 93% identical with a highly conserved region of the 3'-untranslated sequence of rat elastin cDNA.(ABSTRACT TRUNCATED AT 250 WORDS) ..
Li W, Nugent M, Zhao Y, Chau A, Li S, Chou I, et al
. Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential. J Cell Biochem. 2003;88:152-64 pubmed
..The present results illustrate a mechanism by which LO can depress normal and transformed cell growth. ..
Sugitani H, Wachi H, Mecham R, Seyama Y. Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells. J Atheroscler Thromb. 2002;9:292-8 pubmed
..In cases of vascular calcification, the decreased expression of TE, FBN1, and LO may be partially responsible for decreased vascular elasticity and also for the decreased formation of new elastic fibers. ..
Wang S, Mure M, Medzihradszky K, Burlingame A, Brown D, Dooley D, et al
. A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains. Science. 1996;273:1078-84 pubmed
..This discovery expands the range of known quino-cofactor structures and has implications for the mechanism of their biogenesis. ..
Borel A, Eichenberger D, Farjanel J, Kessler E, Gleyzal C, Hulmes D, et al
. Lysyl oxidase-like protein from bovine aorta. Isolation and maturation to an active form by bone morphogenetic protein-1. J Biol Chem. 2001;276:48944-9 pubmed
..The immunopurified protein was largely inactive, but further processing in vitro by bone morphogenetic protein-1 led to an enzyme that was active on elastin and collagen substrates. ..
Rodriguez C, Alcudia J, Martinez Gonzalez J, Guadall A, Raposo B, Sánchez Gómez S, et al
. Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors. Cardiovasc Res. 2009;83:595-603 pubmed publisher
..induced by risk factors and proinflammatory cytokines is associated with down-regulation of lysyl oxidase (LOX), a key enzyme modulating extracellular matrix maturation and vascular integrity...
Kothapalli C, Ramamurthi A. Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells. J Tissue Eng Regen Med. 2009;3:655-61 pubmed publisher
Lysyl oxidase (LOX) is a copper-dependent enzyme that initiates covalent crosslinking of elastin precursors by oxidizing peptidyl lysine to aminoadipic semi-aldehydes...
Atsawasuwan P, Mochida Y, Katafuchi M, Tokutomi K, Mocanu V, Parker C, et al
. A novel proteolytic processing of prolysyl oxidase. Connect Tissue Res. 2011;52:479-86 pubmed publisher
Lysyl oxidase (LOX) is an amine oxidase that is critical for the stability of connective tissues...