Gene Symbol: LGALS1
Description: galectin 1
Alias: galectin-1, 14 kDa lectin, S-Lac lectin 1, beta-galactoside-binding lectin L-14-I, gal-1, galaptin, lactose-binding lectin 1, lectin galactoside-binding soluble 1, lectin, galactoside-binding, soluble, 1 (galectin 1)
Abbott W, Feizi T. Soluble 14-kDa beta-galactoside-specific bovine lectin. Evidence from mutagenesis and proteolysis that almost the complete polypeptide chain is necessary for integrity of the carbohydrate recognition domain. J Biol Chem. 1991;266:5552-7 pubmed
Okumu L, Fair T, Szekeres Bartho J, O Doherty A, Crowe M, Roche J, et al
. Endometrial expression of progesterone-induced blocking factor and galectins-1, -3, -9, and -3 binding protein in the luteal phase and early pregnancy in cattle. Physiol Genomics. 2011;43:903-10 pubmed publisher
..On day 16, expression increased only in the pregnant heifers (P < 0.0001). LGALS1 and LGALS3 decreased on day 7 (P < 0.0001) and remained low until day 16...
Sano M, Hashiba K, Nio Kobayashi J, Okuda K. The luteotrophic function of galectin-1 by binding to the glycans on vascular endothelial growth factor receptor-2 in bovine luteal cells. J Reprod Dev. 2015;61:439-48 pubmed publisher
..The overall findings suggest that galectin-1 plays a role as a survival factor in the bovine CL, possibly by binding to N-glycans on VEGFR-2. ..
Tracey B, Feizi T, Abbott W, Carruthers R, Green B, Lawson A. Subunit molecular mass assignment of 14,654 Da to the soluble beta-galactoside-binding lectin from bovine heart muscle and demonstration of intramolecular disulfide bonding associated with oxidative inactivation. J Biol Chem. 1992;267:10342-7 pubmed
..M., and Feizi, T. (1991) J. Biol. Chem. 266, 5552-5557) point to intramolecular disulfide bonding with a change in protein folding and conformation as the mechanism of oxidative inactivation of the purified bovine lectin. ..
Abbott W, Mellor A, Edwards Y, Feizi T. Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein. Biochem J. 1989;259:283-90 pubmed
..In myelin basic protein the tetrapeptide is a part of the major domain previously shown to be responsible for the induction of experimental allergic encephalomyelitis. ..
Southan C, Aitken A, Childs R, Abbott W, Feizi T. Amino acid sequence of beta-galactoside-binding bovine heart lectin. Member of a novel class of vertebrate proteins. FEBS Lett. 1987;214:301-4 pubmed
..Computer searching of protein sequence databases did not detect significant homologies between the bovine lectin sequence and other known proteins. ..
Bourne Y, Bolgiano B, Liao D, Strecker G, Cantau P, Herzberg O, et al
. Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides. Nat Struct Biol. 1994;1:863-70 pubmed
..The oligosaccharide adopts a different low energy conformation in each of the three crystal forms. ..
Liao D, Kapadia G, Ahmed H, Vasta G, Herzberg O. Structure of S-lectin, a developmentally regulated vertebrate beta-galactoside-binding protein. Proc Natl Acad Sci U S A. 1994;91:1428-32 pubmed
..The specificity for beta-galactose arises from intricate interactions that constrain the position of the O4 atom. ..
Echeverria I, Amzel L. Disaccharide binding to galectin-1: free energy calculations and molecular recognition mechanism. Biophys J. 2011;100:2283-92 pubmed publisher