Gene Symbol: ITGB2
Description: integrin subunit beta 2
Alias: CD18, integrin beta-2, CD18 subunit, Leu-CAM receptor, cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, complement receptor C3 subunit beta, integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2), integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Species: cow
Products:     ITGB2

Top Publications

  1. Shuster D, Bosworth B, Kehrli M. Sequence of the bovine CD18-encoding cDNA: comparison with the human and murine glycoproteins. Gene. 1992;114:267-71 pubmed
    The bovine cDNA (CD18) encoding CD18, a cell-surface glycoprotein involved in multiple leukocyte functions, was sequenced and compared with the human and murine sequences...
  2. Shanthalingam S, Srikumaran S. Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin. Proc Natl Acad Sci U S A. 2009;106:15448-53 pubmed publisher
    ..Here, we report that, contrary to the paradigm, the signal peptide of ruminant CD18, the beta-subunit of beta(2)-integrins, is not cleaved...
  3. Shuster D, Kehrli M, Ackermann M, Gilbert R. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Proc Natl Acad Sci U S A. 1992;89:9225-9 pubmed
    Two point mutations were identified within the gene encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency (LAD)...
  4. Diez Fraile A, Meyer E, Duchateau L, Burvenich C. L-selectin and beta2-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitis. J Dairy Sci. 2003;86:2334-42 pubmed
    ..lipopolysaccharide, LPS) on the expression of L-selectin (CD62L) and the beta2-integrin subunits CD11b and CD18 on circulating bovine PMN. Six early lactating cows were infused with Escherichia coli LPS...
  5. Dassanayake R, Maheswaran S, Srikumaran S. Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects. Infect Immun. 2007;75:5004-10 pubmed
    ..These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.
  6. Nasreen F, Malik N, Qureshi J, Raadsma H, Tammen I. Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus × Bos taurus cattle. Mol Cell Probes. 2012;26:259-62 pubmed publisher
    ..indicus × B. taurus genomic DNA surrounding the disease causing mutation (c.383A > G) in the ITGB2 gene identified numerous variations in exonic and intronic regions within and between species, including ..
  7. Wang J, Kieba I, Korostoff J, Guo T, Yamaguchi N, Rozmiarek H, et al. Molecular and biochemical mechanisms of Pasteurella haemolytica leukotoxin-induced cell death. Microb Pathog. 1998;25:317-31 pubmed
    ..This study provides new insights into understanding the pathogenesis of bovine pasteurellosis and could lead to the development of both preventative and therapeutic strategies for disease management. ..
  8. Lecchi C, Ceciliani F, Bernasconi S, Franciosi F, Bronzo V, Sartorelli P. Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression. Vet Res. 2008;39:50 pubmed publisher
    ..the molecular basis of this finding, the expression of the molecules mostly involved in chemotaxis, including CD18, CD11b and CD47 was studied...
  9. Jeyaseelan S, Hsuan S, Kannan M, Walcheck B, Wang J, Kehrli M, et al. Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes. Infect Immun. 2000;68:72-9 pubmed
    ..Recent studies indicate that P. haemolytica Lkt binds to bovine CD18, the common subunit of all beta2 integrins...

More Information


  1. Nasreen F, Altaf Malik N, Naeem Riaz M, Anver Qureshi J. Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods. Hereditas. 2009;146:74-8 pubmed publisher infections caused by the lack of a membrane glycoprotein called the leukocyte integrin beta-2 subunit of CD18. The present study was planned to standardize a technique for the diagnosis of BLAD and to get an estimation of ..
  2. Kriegesmann B, Jansen S, Baumgartner B, Brenig B. Partial genomic structure of the bovine CD18 gene and the refinement of test for bovine leukocyte adhesion deficiency. J Dairy Sci. 1997;80:2547-9 pubmed
  3. Nagahata H, Higuchi H, Teraoka H, Takahashi K, Takahashi K, Kuwabara M, et al. Decreased apoptosis of beta 2- integrin-deficient bovine neutrophils. Immunol Cell Biol. 2004;82:32-7 pubmed
    ..calves and three calves with leucocyte adhesion deficiency were determined to evaluate the apoptosis of normal and CD18-deficient neutrophils...
  4. Pate B, White K, Winger Q, Rickords L, Aston K, Sessons B, et al. Specific integrin subunits in bovine oocytes, including novel sequences for alpha 6 and beta 3 subunits. Mol Reprod Dev. 2007;74:600-7 pubmed
    ..The presence of these integrin subunits on the bovine oocyte vitelline membrane supports the hypothesis that sperm-oocyte interactions in the bovine are mediated by integrins. ..
  5. Dileepan T, Kannan M, Walcheck B, Maheswaran S. Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility. FEMS Microbiol Lett. 2007;274:67-72 pubmed its biological effects resides within amino acid residues 500-600 of the extracellular region of bovine CD18. Experiments were designed to identify a much smaller functional domain within this 100 amino acid region of bovine ..