Gene Symbol: interleukin 4
Description: interleukin 4
Alias: BSF-1, IL-4, interleukin-4, B-cell stimulatory factor 1, lymphocyte stimulatory factor 1
Heussler V, Eichhorn M, Dobbelaere D. Cloning of a full-length cDNA encoding bovine interleukin 4 by the polymerase chain reaction. Gene. 1992;114:273-8 pubmed
A human interleukin 4 (hIL-4)-encoding cDNA (hIL4) probe was used to screen a bovine genomic library, and three clones containing sequences with homology to the human and mouse IL4 cDNAs were isolated...
Woods A, Judd A. Interleukin-4 increases cortisol release and decreases adrenal androgen release from bovine adrenal cells. Domest Anim Endocrinol. 2008;34:372-82 pubmed
..Because communication between the immune and endocrine systems is important in inflammatory conditions, IL-4 may play a role in coordinating the adrenal response to inflammatory stress...
Ohta Y, Hayashi M, Kanemaru T, Abe K, Ito Y, Oike M. Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production. J Immunol. 2008;180:4191-9 pubmed
..This indicates that Th2 cytokines modulate airway contraction without affecting cellular contractility but by secreting MMP-1 from the SM cells via PI3K activation and changing cell-to-matrix interactions. ..
Paibomesai M, Hussey B, Nino Soto M, Mallard B. Effects of parturition and dexamethasone on DNA methylation patterns of IFN-? and IL-4 promoters in CD4+ T-lymphocytes of Holstein dairy cows. Can J Vet Res. 2013;77:54-62 pubmed
..Dex) had significant effects on production of the cytokines interferon gamma (IFN-?, type 1) and interleukin 4 (IL-4, type 2) that were consistent with DNA methylation profiles of the IFN-? gene promoter region but not ..
Buitkamp J, Schwaiger F, Solinas Toldo S, Fries R, Epplen J. The bovine interleukin-4 gene: genomic organization, localization, and evolution. Mamm Genome. 1995;6:350-6 pubmed
..The IL4 gene has been assigned to 7q15-q21 by fluorescence in situ hybridization in cattle. Evolutionary aspects are discussed on the basis of sequence data as well as interspecies chromosomal homologies. ..