interleukin 1 beta


Gene Symbol: interleukin 1 beta
Description: interleukin 1 beta
Alias: interleukin-1 beta, IL-1 beta
Species: cow
Products:     interleukin 1 beta

Top Publications

  1. Summers L, Kielty C, Pinteaux E. Adhesion to fibronectin regulates interleukin-1 beta expression in microglial cells. Mol Cell Neurosci. 2009;41:148-55 pubmed publisher
    ..These data suggest an important regulatory mechanism of IL-1 production, associated with microglial migration and proliferation, driven by ECM degradation and/or synthesis in an injured brain. ..
  2. Murayama C, Kaji A, Miyauchi K, Matsui M, Miyamoto A, Shimizu T. Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cells. Cell Biol Int. 2010;34:531-6 pubmed publisher
    ..Taken together, our data suggested that VEGF is associated with the IL system in theca cells in bovine ovary...
  3. Chowdhury T, Salter D, Bader D, Lee D. Signal transduction pathways involving p38 MAPK, JNK, NFkappaB and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1beta and dynamic compression. Inflamm Res. 2008;57:306-13 pubmed publisher
    ..This experimental approach could provide valuable information for the biophysical/pharmacological treatment of OA. ..
  4. Maliszewski C, Baker P, Schoenborn M, Davis B, Cosman D, Gillis S, et al. Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAs. Mol Immunol. 1988;25:429-37 pubmed
    ..Both IL-1 alpha and IL-1 beta exist as single genomic copies. In addition, bovine IL-1 beta mRNA is approx. 10-fold more abundant than IL-1 alpha mRNA in stimulated alveolar macrophages. ..
  5. Bagu E, Gordon J, Rawlings N. Post-natal changes in testicular concentrations of interleukin-1 alpha and beta and interleukin-6 during sexual maturation in bulls. Reprod Domest Anim. 2010;45:336-41 pubmed publisher
    ..These findings suggest a functional role for interleukins in testicular development in the bull. ..
  6. DuRaine G, NEU C, Chan S, Komvopoulos K, JUNE R, Reddi A. Regulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta. J Orthop Res. 2009;27:249-56 pubmed publisher
    ..These findings demonstrate that the low friction of articular cartilage can be modified by TGF-beta1 and IL-1beta treatment and that the friction coefficient depends on multiple factors, including SZP localization and surface roughness. ..
  7. ElNaggar M, Abdellrazeq G, Elsisy A, Mahmoud A, Shyboub A, Sester M, et al. Evaluation of antigen specific interleukin-1β as a biomarker to detect cattle infected with Mycobacterium bovis. Tuberculosis (Edinb). 2017;105:53-59 pubmed publisher
    ..IL-1β has the potential to serve as an additional biomarker for detecting cattle infected with Mbv. ..
  8. Correia Álvarez E, Gómez E, Martín D, Carrocera S, Pérez S, Otero J, et al. Expression and localization of interleukin 1 beta and interleukin 1 receptor (type I) in the bovine endometrium and embryo. J Reprod Immunol. 2015;110:1-13 pubmed publisher
    ..In this work, we assessed the expression of IL 1 beta (IL1B) and its receptor, interleukin 1 receptor type I (IL1R1) in the bovine endometrium and embryos by RT-PCR, ..
  9. Roy S, Samanta K, Chakraborti T, Chowdhury A, Chakraborti S. Role of TGF-?1 and TNF-? in IL-1? mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease. Arch Biochem Biophys. 2011;513:61-9 pubmed publisher
    ..Thus, IL-1? induced stimulation of the two progelatinases occurs via different mechanisms. ..

More Information


  1. Oviedo Boyso J, Cardoso Correa B, Cajero Juárez M, Bravo Patiño A, Valdez Alarcón J, Baizabal Aguirre V. The capacity of bovine endothelial cells to eliminate intracellular Staphylococcus aureus and Staphylococcus epidermidis is increased by the proinflammatory cytokines TNF-alpha and IL-1beta. FEMS Immunol Med Microbiol. 2008;54:53-9 pubmed publisher
    ..aureus and S. epidermidis and suggest that endothelial cells may play a prominent role in the defense against infections caused by these bacteria. ..
  2. Leong S, Flaggs G, Lawman M, Gray P. The nucleotide sequence for the cDNA of bovine interleukin-1 beta. Nucleic Acids Res. 1988;16:9054 pubmed
  3. Sohn E, Paape M, Connor E, Bannerman D, Fetterer R, Peters R. Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Vet Res. 2007;38:809-18 pubmed
  4. Tanikawa M, Kim T, Okuda K, Ryoo Z, Park S, Shin J, et al. Cell-type specificity of interleukins 1alpha and 1beta on prostaglandin and plasminogen activator production in bovine endometrial cells. Anim Reprod Sci. 2009;114:32-42 pubmed publisher
  5. Wilson C, Palmer A, Zuo F, Eugui E, Wilson S, Mackenzie R, et al. Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties. Matrix Biol. 2007;26:259-68 pubmed
    ..The data suggest that non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties. ..
  6. Caroprese M, Albenzio M, Annicchiarico G, Sevi A. Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period. J Dairy Sci. 2006;89:562-8 pubmed
    ..In contrast, a relationship was found for the IgG secretions in milk and blood, which suggests that the assessment of humoral immune status may be combined with milking routine in dairy animals. ..
  7. Hussen J, D vel A, Koy M, Schuberth H. Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7. Dev Comp Immunol. 2012;38:312-20 pubmed publisher
    ..The data indicate that ROS generation plays no role in the ATP-induced activation of inflammasome in bovine monocytes and that P2X7-mediated pore formation is not necessary for the release of Interleukin-1?...
  8. Heaton M, Harhay G, Bennett G, Stone R, Grosse W, Casas E, et al. Selection and use of SNP markers for animal identification and paternity analysis in U.S. beef cattle. Mamm Genome. 2002;13:272-81 pubmed
    ..Knowledge of these additional sites, together with the 32 target SNPs, allows the design of robust, accurate genotype assays on a variety of high-throughput SNP genotyping platforms. ..
  9. Nishimura R, Bowolaksono A, Acosta T, Murakami S, Piotrowska K, Skarzynski D, et al. Possible role of interleukin-1 in the regulation of bovine corpus luteum throughout the luteal phase. Biol Reprod. 2004;71:1688-93 pubmed