interleukin 1 alpha


Gene Symbol: interleukin 1 alpha
Description: interleukin 1 alpha
Alias: interleukin-1 alpha, IL-1 alpha
Species: cow
Products:     interleukin 1 alpha

Top Publications

  1. Leong S, Flaggs G, Lawman M, Gray P. The nucleotide sequence for the cDNA of bovine interleukin-1 alpha. Nucleic Acids Res. 1988;16:9053 pubmed
  2. Gilbert S, Blain E, al Sabah A, Zhang Y, Duance V, Mason D. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. Eur Cell Mater. 2012;23:41-57 pubmed
    ..This study demonstrates, for the first time, that a number of catabolic and pro-inflammatory effects known to be important in human arthritis and induced by OSM and IL-1, are mediated by the PKR signalling pathway. ..
  3. Nishimura R, Bowolaksono A, Acosta T, Murakami S, Piotrowska K, Skarzynski D, et al. Possible role of interleukin-1 in the regulation of bovine corpus luteum throughout the luteal phase. Biol Reprod. 2004;71:1688-93 pubmed
  4. Tanikawa M, Kim T, Okuda K, Ryoo Z, Park S, Shin J, et al. Cell-type specificity of interleukins 1alpha and 1beta on prostaglandin and plasminogen activator production in bovine endometrial cells. Anim Reprod Sci. 2009;114:32-42 pubmed publisher
  5. Maliszewski C, Baker P, Schoenborn M, Davis B, Cosman D, Gillis S, et al. Cloning, sequence and expression of bovine interleukin 1 alpha and interleukin 1 beta complementary DNAs. Mol Immunol. 1988;25:429-37 pubmed
    ..Both IL-1 alpha and IL-1 beta exist as single genomic copies. In addition, bovine IL-1 beta mRNA is approx. 10-fold more abundant than IL-1 alpha mRNA in stimulated alveolar macrophages. ..
  6. Bagu E, Gordon J, Rawlings N. Post-natal changes in testicular concentrations of interleukin-1 alpha and beta and interleukin-6 during sexual maturation in bulls. Reprod Domest Anim. 2010;45:336-41 pubmed publisher
    ..These findings suggest a functional role for interleukins in testicular development in the bull. ..
  7. Wilson C, Palmer A, Zuo F, Eugui E, Wilson S, Mackenzie R, et al. Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties. Matrix Biol. 2007;26:259-68 pubmed
    ..The data suggest that non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties. ..
  8. Estell E, Murphy L, Silverstein A, Tan A, Shah R, Ateshian G, et al. Fibroblast-like synoviocyte mechanosensitivity to fluid shear is modulated by interleukin-1?. J Biomech. 2017;60:91-99 pubmed publisher