IL6R

Summary

Gene Symbol: IL6R
Description: interleukin 6 receptor
Alias: interleukin-6 receptor subunit alpha
Species: cow

Top Publications

  1. Legendre F, Dudhia J, Pujol J, Bogdanowicz P. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem. 2003;278:2903-12 pubmed
    ..These IL-6 effects might contribute to the phenotype loss of chondrocytes in joint diseases and the alteration of articular cartilage associated with this pathology. ..
  2. Sui Y, Lee J, DiMicco M, Vanderploeg E, Blake S, Hung H, et al. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum. 2009;60:2985-96 pubmed publisher
    ..The catabolic effects of injury plus TNFalpha appeared partly due to endogenous IL-6, since GAG loss was partially abrogated by an IL-6-blocking Fab. ..