Gene Symbol: IL6
Description: interleukin 6
Alias: interleukin-6, IL-6, interleukin 6 (interferon, beta 2)
Species: cow
Products:     IL6

Top Publications

  1. Legendre F, Dudhia J, Pujol J, Bogdanowicz P. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem. 2003;278:2903-12 pubmed
    ..These IL-6 effects might contribute to the phenotype loss of chondrocytes in joint diseases and the alteration of articular cartilage associated with this pathology. ..
  2. Caroprese M, Albenzio M, Annicchiarico G, Sevi A. Changes occurring in immune responsiveness of single- and twin-bearing Comisana ewes during the transition period. J Dairy Sci. 2006;89:562-8 pubmed
    ..In contrast, a relationship was found for the IgG secretions in milk and blood, which suggests that the assessment of humoral immune status may be combined with milking routine in dairy animals. ..
  3. Xu G, Li Y, Yang J, Zhou X, Yin X, Liu M, et al. Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages. Mol Cell Biochem. 2007;302:1-7 pubmed
    ..This study suggests that Mce4A proteins may induce the body's inflammation response to M. bovis and therefore may play an important role in the immune response. ..
  4. Sui Y, Lee J, DiMicco M, Vanderploeg E, Blake S, Hung H, et al. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum. 2009;60:2985-96 pubmed publisher
    ..The catabolic effects of injury plus TNFalpha appeared partly due to endogenous IL-6, since GAG loss was partially abrogated by an IL-6-blocking Fab. ..
  5. Lau A, Kollara A, St John E, Tone A, Virtanen C, Greenblatt E, et al. Altered expression of inflammation-associated genes in oviductal cells following follicular fluid exposure: implications for ovarian carcinogenesis. Exp Biol Med (Maywood). 2014;239:24-32 pubmed publisher
    ..Tumor necrosis factor (TNF) and IL6 levels were also decreased while those of nicotinomide phosphoribosyltransferase (NAMPT) were unaffected...
  6. Gowane G, Sharma A, Sankar M, Narayanan K, Bisht P, Subramaniam S, et al. The expression of IL6 and 21 in crossbred calves upregulated by inactivated trivalent FMD vaccine. Anim Biotechnol. 2014;25:108-18 pubmed publisher
    ..Based on the specific role of IL6 and 21 in adaptive immune response, we hypothesized that inactivated trivalent FMD vaccine would stimulate IL6 and ..
  7. Bagu E, Gordon J, Rawlings N. Post-natal changes in testicular concentrations of interleukin-1 alpha and beta and interleukin-6 during sexual maturation in bulls. Reprod Domest Anim. 2010;45:336-41 pubmed publisher
    ..These findings suggest a functional role for interleukins in testicular development in the bull. ..
  8. Healy L, Cronin J, Sheldon I. Polarized Epithelial Cells Secrete Interleukin 6 Apically in the Bovine Endometrium. Biol Reprod. 2015;92:151 pubmed publisher
    ..The present study tested the hypothesis that IL6 is predominantly secreted apically from polarized bovine endometrial epithelial cells in response to stimuli ..
  9. Droogmans L, Cludts I, Cleuter Y, Kettmann R, Burny A. Nucleotide sequence of bovine interleukin-6 cDNA. DNA Seq. 1992;2:411-3 pubmed
    ..The significance of IL-6 expression in a BLV-induced tumor is briefly discussed. ..

More Information


  1. Cronin J, Kanamarlapudi V, Thornton C, Sheldon I. Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. Mucosal Immunol. 2016;9:1125-36 pubmed publisher
    b>Interleukin 6 (IL-6), acting via the IL-6 receptor (IL6R) and signal transducer and activator of transcription-3 (STAT3), limits neutrophil recruitment once bacterial infections are resolved...