Gene Symbol: IL12B
Description: interleukin 12B
Alias: IL12p40, interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, IL-12B, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin 12 40kDa subunit, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Collins R, Howard C, Duggan S, Werling D. Bovine interleukin-12 and modulation of IFNgamma production. Vet Immunol Immunopathol. 1999;68:193-207 pubmed
..This study shows that antigen-driven responses in cattle can be significantly influenced by exogenous cytokines and suggests the IL-12/IL-10 balance is crucial for regulation of IFNgamma. ..
Sohn E, Paape M, Connor E, Bannerman D, Fetterer R, Peters R. Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Vet Res. 2007;38:809-18 pubmed
Chaplin P, Camon E, Villarreal Ramos B, Flint M, Ryan M, Collins R. Production of interleukin-12 as a self-processing 2A polypeptide. J Interferon Cytokine Res. 1999;19:235-41 pubmed
..We propose that this strategy of self-processing polypeptides may be used in many applications where the coordinated and stoichiometric expression of complex proteins is required. ..
Xu G, Li Y, Yang J, Zhou X, Yin X, Liu M, et al
. Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages. Mol Cell Biochem. 2007;302:1-7 pubmed
..This study suggests that Mce4A proteins may induce the body's inflammation response to M. bovis and therefore may play an important role in the immune response. ..
Wolf S, Temple P, Kobayashi M, Young D, Dicig M, Lowe L, et al
. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol. 1991;146:3074-81 pubmed
..The synergistic stimulation by NKSF plus IL-2 of T and NK function supports the possibility that these cytokines might prove useful in cancer therapy. ..
Zarlenga D, Canals A, Aschenbrenner R, Gasbarre L. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12. Biochim Biophys Acta. 1995;1270:215-7 pubmed
..6% homology with human and mouse sequences, respectively. The deduced sequence of the 35 kDa subunit exhibited comparable similarities to the human 35 kDa subunit (82.2%) but differed significantly (58.6%) from mouse-derived sequences. ..
Hope J, Kwong L, Entrican G, Wattegedera S, Vordermeier H, Sopp P, et al
. Development of detection methods for ruminant interleukin (IL)-12. J Immunol Methods. 2002;266:117-26 pubmed
..The ability to detect ruminant IL-12 by three methods: ELISA, bioassay with neutralising mAb and cytoplasmic staining, will permit studies of the role of this important cytokine in the immunology and pathogenesis of animal diseases. ..
Sommer S, Pudrith C, Colvin C, Coussens P. Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Vet Immunol Immunopathol. 2009;128:44-52 pubmed publisher
..Because early activation of p38 was unimpaired in MAP-infected macrophages, we propose that MAP interferes with gene expression of iNOS and IL-12p40 genes downstream of p38. ..