Gene Symbol: IL12A
Description: interleukin 12A
Alias: IL12p35, Il-12 p35, interleukin-12 subunit alpha, CLMF p35, IL-12 subunit p35, IL-12A, cytotoxic lymphocyte maturation factor 35 kDa subunit, interleukin 12 35kDa subunit, interleukin 12 polypeptide 35, natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35
Zarlenga D, Canals A, Aschenbrenner R, Gasbarre L. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12. Biochim Biophys Acta. 1995;1270:215-7 pubmed
..6% homology with human and mouse sequences, respectively. The deduced sequence of the 35 kDa subunit exhibited comparable similarities to the human 35 kDa subunit (82.2%) but differed significantly (58.6%) from mouse-derived sequences. ..
Schmidt P, Kuhn C, Kang a S, Hanotte O, Vanselow J, Anton I, et al
. Interleukin-12 p35 encoding gene of cattle and sheep harbours a polymorphic T stretch in intron 4. Anim Genet. 2000;31:283-5 pubmed
Hope J, Kwong L, Entrican G, Wattegedera S, Vordermeier H, Sopp P, et al
. Development of detection methods for ruminant interleukin (IL)-12. J Immunol Methods. 2002;266:117-26 pubmed
..The ability to detect ruminant IL-12 by three methods: ELISA, bioassay with neutralising mAb and cytoplasmic staining, will permit studies of the role of this important cytokine in the immunology and pathogenesis of animal diseases. ..
Xu G, Li Y, Yang J, Zhou X, Yin X, Liu M, et al
. Effect of recombinant Mce4A protein of Mycobacterium bovis on expression of TNF-alpha, iNOS, IL-6, and IL-12 in bovine alveolar macrophages. Mol Cell Biochem. 2007;302:1-7 pubmed
..This study suggests that Mce4A proteins may induce the body's inflammation response to M. bovis and therefore may play an important role in the immune response. ..
Wolf S, Temple P, Kobayashi M, Young D, Dicig M, Lowe L, et al
. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol. 1991;146:3074-81 pubmed
..The synergistic stimulation by NKSF plus IL-2 of T and NK function supports the possibility that these cytokines might prove useful in cancer therapy. ..
Chaplin P, Camon E, Villarreal Ramos B, Flint M, Ryan M, Collins R. Production of interleukin-12 as a self-processing 2A polypeptide. J Interferon Cytokine Res. 1999;19:235-41 pubmed
..We propose that this strategy of self-processing polypeptides may be used in many applications where the coordinated and stoichiometric expression of complex proteins is required. ..
Collins R, Howard C, Duggan S, Werling D. Bovine interleukin-12 and modulation of IFNgamma production. Vet Immunol Immunopathol. 1999;68:193-207 pubmed
..This study shows that antigen-driven responses in cattle can be significantly influenced by exogenous cytokines and suggests the IL-12/IL-10 balance is crucial for regulation of IFNgamma. ..
Sohn E, Paape M, Connor E, Bannerman D, Fetterer R, Peters R. Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma. Vet Res. 2007;38:809-18 pubmed