IL10

Summary

Gene Symbol: IL10
Description: interleukin 10
Alias: interleukin-10, CSIF, IL-10, cytokine synthesis inhibitory factor
Species: cow
Products:     IL10

Top Publications

  1. Goff W, Johnson W, Parish S, Barrington G, Elsasser T, Davis W, et al. IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites. Vet Immunol Immunopathol. 2002;84:237-51 pubmed
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  2. Vieira P, de Waal Malefyt R, Dang M, Johnson K, Kastelein R, Fiorentino D, et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci U S A. 1991;88:1172-6 pubmed
    We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone...
  3. Moore K, de Waal Malefyt R, Coffman R, O GARRA A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765 pubmed
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  4. Weiss D, Evanson O, Souza C. Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility of cattle to infection with Mycobacterium avium subsp paratuberculosis. Am J Vet Res. 2005;66:1114-20 pubmed
  5. Taga K, Cherney B, Tosato G. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int Immunol. 1993;5:1599-608 pubmed
    ..Thus, another property of IL-10 is to promote the survival of IL-2-dependent T cells otherwise destined to die by apoptosis. ..
  6. Taga K, Mostowski H, Tosato G. Human interleukin-10 can directly inhibit T-cell growth. Blood. 1993;81:2964-71 pubmed
    ..Secretion of IL-2 under these conditions was inhibited by IL-10 (51.5% inhibition). Thus, IL-10 can directly inhibit growth and IL-2 production in T cells triggered by immobilized OKT3 MoAb in the absence of monocytes. ..
  7. O Farrell A, Liu Y, Moore K, Mui A. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 1998;17:1006-18 pubmed
    ..Thus signals mediating both anti-proliferative and macrophage de-activation responses to IL-10 require the two membrane-distal tyrosines of IL-10R, but Stat3 appears to function only in the anti-proliferative response. ..
  8. Kwong L, Hope J, Thom M, Sopp P, Duggan S, Bembridge G, et al. Development of an ELISA for bovine IL-10. Vet Immunol Immunopathol. 2002;85:213-23 pubmed
  9. Peli A, Luciani A, De Santis P, Polci A, Britti D. Quantitation of the cytokines TNF-alpha, IL-8 and IL-10 in bovine milk using real-time TaqMan PCR. Vet Res Commun. 2004;28 Suppl 1:359-62 pubmed
  10. Shirasuna K, Matsumoto H, Kobayashi E, Nitta A, Haneda S, Matsui M, et al. Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows. J Reprod Dev. 2012;58:84-90 pubmed
    ..The results suggest that ISGs and IL-10 could be responsive to IFNT before the MRP in peripheral blood immune cells and may be useful target genes for reliable indices of pregnancy before the MRP. ..

Detail Information

Publications15

  1. Goff W, Johnson W, Parish S, Barrington G, Elsasser T, Davis W, et al. IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites. Vet Immunol Immunopathol. 2002;84:237-51 pubmed
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  2. Vieira P, de Waal Malefyt R, Dang M, Johnson K, Kastelein R, Fiorentino D, et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci U S A. 1991;88:1172-6 pubmed
    We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone...
  3. Moore K, de Waal Malefyt R, Coffman R, O GARRA A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765 pubmed
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  4. Weiss D, Evanson O, Souza C. Expression of interleukin-10 and suppressor of cytokine signaling-3 associated with susceptibility of cattle to infection with Mycobacterium avium subsp paratuberculosis. Am J Vet Res. 2005;66:1114-20 pubmed
  5. Taga K, Cherney B, Tosato G. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int Immunol. 1993;5:1599-608 pubmed
    ..Thus, another property of IL-10 is to promote the survival of IL-2-dependent T cells otherwise destined to die by apoptosis. ..
  6. Taga K, Mostowski H, Tosato G. Human interleukin-10 can directly inhibit T-cell growth. Blood. 1993;81:2964-71 pubmed
    ..Secretion of IL-2 under these conditions was inhibited by IL-10 (51.5% inhibition). Thus, IL-10 can directly inhibit growth and IL-2 production in T cells triggered by immobilized OKT3 MoAb in the absence of monocytes. ..
  7. O Farrell A, Liu Y, Moore K, Mui A. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 1998;17:1006-18 pubmed
    ..Thus signals mediating both anti-proliferative and macrophage de-activation responses to IL-10 require the two membrane-distal tyrosines of IL-10R, but Stat3 appears to function only in the anti-proliferative response. ..
  8. Kwong L, Hope J, Thom M, Sopp P, Duggan S, Bembridge G, et al. Development of an ELISA for bovine IL-10. Vet Immunol Immunopathol. 2002;85:213-23 pubmed
  9. Peli A, Luciani A, De Santis P, Polci A, Britti D. Quantitation of the cytokines TNF-alpha, IL-8 and IL-10 in bovine milk using real-time TaqMan PCR. Vet Res Commun. 2004;28 Suppl 1:359-62 pubmed
  10. Shirasuna K, Matsumoto H, Kobayashi E, Nitta A, Haneda S, Matsui M, et al. Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows. J Reprod Dev. 2012;58:84-90 pubmed
    ..The results suggest that ISGs and IL-10 could be responsive to IFNT before the MRP in peripheral blood immune cells and may be useful target genes for reliable indices of pregnancy before the MRP. ..
  11. Zuśka Prot M, Maslanka T, Jasiecka A, Jaroszewski J. Prostaglandin E2 inhibits IL-10 production by bovine CD4+ T cells. Pol J Vet Sci. 2014;17:511-3 pubmed
  12. Hash S, Brown W, Rice Ficht A. Characterization of a cDNA encoding bovine interleukin 10: kinetics of expression in bovine lymphocytes. Gene. 1994;139:257-61 pubmed
    A cDNA encoding bovine interleukin 10 (IL10) was cloned and sequenced using total cellular RNA derived from concanavalin A (ConA)-stimulated peripheral blood mononuclear cells (PBMC)...
  13. Fluckiger A, Garrone P, Durand I, Galizzi J, Banchereau J. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J Exp Med. 1993;178:1473-81 pubmed
    b>Interleukin 10 (IL-10) has recently been shown to induce normal human B lymphocytes to proliferate and differentiate into immunoglobulin (Ig)-secreting cells...
  14. den Hartog G, Savelkoul H, Schoemaker R, Tijhaar E, Westphal A, de Ruiter T, et al. Modulation of human immune responses by bovine interleukin-10. PLoS ONE. 2011;6:e18188 pubmed publisher
  15. Raychaudhuri B, Fisher C, Farver C, Malur A, Drazba J, Kavuru M, et al. Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages. Cytokine. 2000;12:1348-55 pubmed
    ..These observations provide the first evidence that IL-10 antagonizes cytokine transcription in human alveolar macrophages by impeding the nuclear translocation of NF-kappa B by delaying the degradation of I kappa B. ..