IFNG

Summary

Gene Symbol: IFNG
Description: interferon, gamma
Alias: IFN-gamma, boIFNG, interferon gamma, interferon gamma type 2, interferon-gamma
Species: cow

Top Publications

  1. ncbi Augmentation of secreted and intracellular gamma interferon following johnin purified protein derivative sensitization of cows naturally infected with Mycobacterium avium subsp. paratuberculosis
    Judith R Stabel
    USDA ARS, National Animal Disease Center, 2300 Dayton Rd, Ames, IA 50010, USA
    J Vet Diagn Invest 19:43-51. 2007
  2. doi Genetic variants in interferon gamma (IFN-γ) gene are associated with resistance against ticks in Bos taurus and Bos indicus
    J Maryam
    Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
    Mol Biol Rep 39:4565-70. 2012
  3. ncbi Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma
    Eun J Sohn
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Vet Res 38:809-18. 2007
  4. doi Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB
    Rocío Pérez-Rodríguez
    Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Spain
    J Neurochem 108:1083-96. 2009
  5. doi Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle
    Pablo J Pinedo
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Prev Vet Med 91:189-96. 2009
  6. doi Difference in the level of interferon gamma mRNA transcripts on stimulation of cattle and buffalo mononuclear cells with foot and mouth disease virus-antigen: a possible role of sequence variation in promoter region
    B Mohana Subramanian
    Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai 600007, India
    Res Vet Sci 90:55-8. 2011
  7. ncbi Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum
    Takuo Hojo
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:515-9. 2010
  8. doi Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls
    Chris P Verschoor
    Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    Anim Biotechnol 22:7-15. 2011
  9. doi Rapid and transient activation of γδ T cells to IFN-γ production, NK cell-like killing, and antigen processing during acute virus infection
    Felix N Toka
    Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11944, USA
    J Immunol 186:4853-61. 2011
  10. ncbi Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 118:50-8. 2007

Scientific Experts

  • M A Gonzalez-Gay
  • D N Wedlock
  • J R Stabel
  • Peter Schmidt
  • Wai Po Chong
  • J Maryam
  • Chris P Verschoor
  • B Mohana Subramanian
  • Felix N Toka
  • Takuo Hojo
  • Rocío Pérez-Rodríguez
  • Pablo J Pinedo
  • Eun J Sohn
  • Chuan Li
  • I R Moldovan
  • Anne Marie Belliard
  • T Hussain
  • M E Babar
  • A Nadeem
  • Bhawani S Sharma
  • K G Tirumurugaan
  • G Dhinakar Raj
  • Flavio S Schenkel
  • Graham A Biggar
  • Sameer D Pant
  • William T Golde
  • D Thiagarajan
  • S Senthuran
  • Mary A Kenney
  • Niel A Karrow
  • Kiyoshi Okuda
  • Tomas J Acosta
  • M Randal
  • Seung Hyung Lee
  • Akihiro ODA
  • Taimour Y Langaee
  • Pedro Melendez
  • D Owen Rae
  • Cesáreo Roncero
  • Claus D Buergelt
  • María Jesús Oset-Gasque
  • Ana María Oliván
  • G Art Donovan
  • María Pilar González
  • Rongling Wu
  • Laurence Morel
  • W M Grosse
  • Erin E Connor
  • Zhang Gui Rong Yan
  • Ying Yut Chen
  • Qiao Yun Hu
  • Huan Chun Chen
  • Raymond H Fetterer
  • Douglas D Bannerman
  • Ya Di Tan
  • Bo Qin
  • Max J Paape
  • Ai Zhen Guo
  • Yan Jie Chao
  • Robert R Peters
  • S E Born
  • A C Cotleur
  • J C Lee
  • C M Pelfrey
  • R A Rudick
  • M T Karafa
  • Bernard Lacour
  • Robert Farinotti
  • Christine Leroy
  • A A Kossiakoff
  • M P Heaton
  • C G Chitko-McKown
  • S M Kappes
  • J W Keele
  • W W Laegreid
  • D P Cerretti
  • D Cosman
  • P E Baker
  • A Larsen
  • S Gillis
  • K McKereghan

Detail Information

Publications21

  1. ncbi Augmentation of secreted and intracellular gamma interferon following johnin purified protein derivative sensitization of cows naturally infected with Mycobacterium avium subsp. paratuberculosis
    Judith R Stabel
    USDA ARS, National Animal Disease Center, 2300 Dayton Rd, Ames, IA 50010, USA
    J Vet Diagn Invest 19:43-51. 2007
    ..In addition, CD8+ lymphocytes appear to play an important role as a mediator of M. paratuberculosis infection in naturally exposed cattle...
  2. doi Genetic variants in interferon gamma (IFN-γ) gene are associated with resistance against ticks in Bos taurus and Bos indicus
    J Maryam
    Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
    Mol Biol Rep 39:4565-70. 2012
    ..Genetic markers identified in this study can be useful in future breeding selection programs against tick resistance...
  3. ncbi Bacterial lipopolysaccharide stimulates bovine neutrophil production of TNF-alpha, IL-1beta, IL-12 and IFN-gamma
    Eun J Sohn
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
    Vet Res 38:809-18. 2007
    ....
  4. doi Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB
    Rocío Pérez-Rodríguez
    Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Spain
    J Neurochem 108:1083-96. 2009
    ..inducible NOS (iNOS) and neuronal NOS (nNOS), and their particular participation in cell death induced by interferon gamma (IFNgamma). Lipopolysaccharide (LPS) and IFNgamma increase iNOS expression, with no effect on nNOS expression...
  5. doi Candidate gene polymorphisms (BoIFNG, TLR4, SLC11A1) as risk factors for paratuberculosis infection in cattle
    Pablo J Pinedo
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0136, USA
    Prev Vet Med 91:189-96. 2009
    ..b>Interferon gamma is an inducible cytokine with a crucial role in the innate host response to intracellular bacteria...
  6. doi Difference in the level of interferon gamma mRNA transcripts on stimulation of cattle and buffalo mononuclear cells with foot and mouth disease virus-antigen: a possible role of sequence variation in promoter region
    B Mohana Subramanian
    Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai 600007, India
    Res Vet Sci 90:55-8. 2011
    ..to compare the mitogen (conA) or antigen (foot and mouth disease virus) induced expression levels of interferon gamma (IFN-γ mRNA in peripheral blood mononuclear cells (PBMCs) by real-time quantitative PCR...
  7. ncbi Effects of tumor necrosis factor α and Interferon γ on the viability and mRNA expression of TNF receptor type I in endothelial cells from the bovine corpus luteum
    Takuo Hojo
    Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Japan
    J Reprod Dev 56:515-9. 2010
    ..We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (TNFRI)...
  8. doi Identification of SNPs in interferon gamma, interleukin-22, and their receptors and associations with health and production-related traits in Canadian Holstein bulls
    Chris P Verschoor
    Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    Anim Biotechnol 22:7-15. 2011
    ..Therefore, in the following study, the genes coding interferon gamma (IFNG), IFNG receptor 1 and 2 domains, interleukin-22 (IL22), and IL22 receptor alpha 1, were investigated ..
  9. doi Rapid and transient activation of γδ T cells to IFN-γ production, NK cell-like killing, and antigen processing during acute virus infection
    Felix N Toka
    Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11944, USA
    J Immunol 186:4853-61. 2011
    ..However, these results are unique in that all these functions are detected in the same samples of WC1(+) γδ T cells, suggesting a pivotal role of these cells in controlling virus infection...
  10. ncbi Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis
    D Neil Wedlock
    AgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand
    Vet Immunol Immunopathol 118:50-8. 2007
    ..The results also show that post-vaccination antigen-specific IFN-gamma levels in whole blood is not always a reliable indicator of protection against a subsequent virulent challenge...
  11. ncbi [Preparation antibodies against recombinant bovine IFN-gamma and development of sandwich ELISA for bovine IFN-gamma detection]
    Chuan Li
    The State Key Laboratory of Agricultural Microbiology, Wuhan 430070, China
    Sheng Wu Gong Cheng Xue Bao 23:40-5. 2007
    ..The results indicated that the sensitivity was 2ng/mL. This sandwich ELISA to detect BovIFN-gamma paved the way to develop a sensitive method for specific infection detection such as bovine tuberculosis diagnosis...
  12. ncbi Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes
    W M Grosse
    United States Department of Agriculture, Agricultural Research Service, Roman L Hruska U S Meat Animal Research Center MARC, P O Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA
    Mamm Genome 10:1062-9. 1999
    ..The polymorphic nature of these SNP haplotype markers suggests that they will be useful for mapping complex traits in cattle, such as resistance to infectious disease...
  13. ncbi The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species
    M Randal
    Graduate Group in Biophysics, University of California, San Francisco, California 94000, USA
    Acta Crystallogr D Biol Crystallogr 56:14-24. 2000
    ..1992), Faraday Discuss. 93, 25-34]. The resulting statistical scoring indicated that BOV was consistent with expected criteria for a 2.0 A structure, whereas both 1rfb and 2rig fell below acceptable criteria...
  14. ncbi A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae
    Peter Schmidt
    Research Unit of Molecular Biology of the Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    J Interferon Cytokine Res 22:923-34. 2002
    ..Therefore, the entire bovine IFN-gamma gene (BoIFNG) and 2605 bp of its promoter DNA were sequenced...
  15. ncbi Effect of tumor necrosis factor-alpha and interferon-gamma on intestinal P-glycoprotein expression, activity, and localization in Caco-2 cells
    Anne Marie Belliard
    Laboratoire de Physiologie Pharmacie Clinique, UPRES 2706, Faculte de Pharmacie, 5 rue J B Clement, 92296 Chatenay Malabry Cedex, France
    J Pharm Sci 93:1524-36. 2004
    ..The aim of this study was to investigate the effects of TNF alpha and IFN gamma on intestinal Pgp expression, activity, and localization in Caco-2 cells grown on filters...
  16. ncbi Interferon-gamma gene microsatellite polymorphisms in patients with biopsy-proven giant cell arteritis and isolated polymyalgia rheumatica
    M A Gonzalez-Gay
    Division of Rheumatology, Hospital Xeral Calde, Lugo, Spain
    Clin Exp Rheumatol 22:S18-20. 2004
    ..In this study we have examined the potential association of a CA repeat polymorphism in the first intron of the interferon gamma (IFN-gamma) gene with disease susceptibility and clinical expression of these conditions.
  17. ncbi Longitudinal single-cell cytokine responses reveal recurrent autoimmune myelin reactivity in relapsing--remitting multiple sclerosis patients
    I R Moldovan
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH 44195 0001, USA
    Mult Scler 11:251-60. 2005
    ..The majority of patients with gad-enhancing lesions showed PLP/IFN gamma and MBP/IFN gamma recurrent burst responses...
  18. pmc The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
    Wai Po Chong
    Department of Paediatrics and Adolescent Medicine, The Hong Kong Jockey Club Research Centre, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    BMC Infect Dis 6:82. 2006
    ..Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS)...
  19. ncbi Cloning, sequence, and expression of bovine interferon-gamma
    D P Cerretti
    J Immunol 136:4561-4. 1986
    ..w. of 16,858. It has an amino acid homology of 63% with human IFN-gamma, and 47% with murine IFN-gamma. Biologically active bovine IFN-gamma was synthesized in an Escherichia coli expression system...