HSP90AA1

Summary

Gene Symbol: HSP90AA1
Description: heat shock protein 90 alpha family class A member 1
Alias: HSPCA, heat shock protein HSP 90-alpha, heat shock 90kD protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1
Species: cow
Products:     HSP90AA1

Top Publications

  1. Hidalgo de Quintana J, Evans R, Cheetham M, van der Spuy J. The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex. Invest Ophthalmol Vis Sci. 2008;49:2878-87 pubmed publisher
  2. Antonov A, Antonova G, Fujii M, Ten Dijke P, Handa V, Catravas J, et al. Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90. J Cell Physiol. 2012;227:759-71 pubmed publisher
    ..We hypothesize that specific translocation of ubiquitinated ALK5 receptor into the cytoskeleton compartment due to its lack of degradation is the mechanism that causes the divergence of caALK1 and caALK5 signaling...
  3. Kobayashi Y, Wakamiya K, Kohka M, Yamamoto Y, Okuda K. Summer heat stress affects prostaglandin synthesis in the bovine oviduct. Reproduction. 2013;146:103-10 pubmed publisher
    ..of microsomal PGE synthase 1 (PTGES (mPGES1)), cytosolic PGES (PTGES3 (cPGES)), and heat shock protein 90 (HSP90AA1 (HSP90)) mRNAs and proteins were higher at 40.5?°C than at 38.5?°C in the ampullary epithelial cells...
  4. Yoshida M, Xia Y. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem. 2003;278:36953-8 pubmed
    ..In light of the critical role of hsp90 in iNOS-mediated cytotoxic action, modulating the interaction between hsp90 and iNOS may be a new approach to intervene inflammation and immune response. ..
  5. Okada M, Hatakeyama T, Itoh H, Tokuta N, Tokumitsu H, Kobayashi R. S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. J Biol Chem. 2004;279:4221-33 pubmed
    ..The results demonstrate a novel physiological function for S100A1 and bring us closer to a comprehensive understanding of the molecular mechanisms of the Hsp70/Hsp90 multichaperone complex. ..
  6. Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King F, et al. Hsp90 chaperones wild-type p53 tumor suppressor protein. J Biol Chem. 2004;279:48836-45 pubmed
    ..In summary, the results presented in this article state that chaperone activity of Hsp90 is important for the transcriptional activity of genotypically wild-type p53. ..
  7. Park S, Suetsugu S, Takenawa T. Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. EMBO J. 2005;24:1557-70 pubmed publisher
    ..These findings suggest that HSP90 induces efficient activation of N-WASP downstream of phosphorylation signal by Src family kinases and is critical for N-WASP-dependent podosome formation and neurite extension...
  8. Nakamura T, Hinagata J, Tanaka T, Imanishi T, Wada Y, Kodama T, et al. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem Biophys Res Commun. 2002;290:858-64 pubmed
    ..These proteins interact with the cytoplasmic domain directly and may have an effect on the functions of MSR such as internalization, cell-surface expression, and signal transduction. ..