Gene Symbol: HIF1A
Description: hypoxia inducible factor 1 subunit alpha
Alias: hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1 alpha subunit, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Species: cow
Products:     HIF1A

Top Publications

  1. Hara S, Kobayashi C, Imura N. Molecular cloning of cDNAs encoding hypoxia-inducible factor (HIF)-1alpha and -2alpha of bovine arterial endothelial cells. Biochim Biophys Acta. 1999;1445:237-43 pubmed
    ..Northern blot analysis indicated that the mRNAs for HIF-1alpha and -2alpha from BAEC showed a size of approx. 5.5 and 6.2 kilobases, respectively and that both mRNAs were constitutively expressed and not induced by hypoxia in BAEC. ..
  2. Yeh L, Alayash A. Effects of cell-free hemoglobin on hypoxia-inducible factor (HIF-1alpha) and heme oxygenase (HO-1) expressions in endothelial cells subjected to hypoxia. Antioxid Redox Signal. 2004;6:944-53 pubmed
    ..DBBF-Hb modulates key cell-signaling pathways by competing with peroxides required for the deactivation of HIF-1alpha, which may modulate important physiological mediators. ..
  3. Eng E, Holgren C, Hubchak S, Naaz P, Schnaper H. Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells. Kidney Int. 2005;68:695-703 pubmed
    ..These hypoxia-regulated interactions may be important during glomerulogenesis in fetal life and during the pathogenesis of adult glomerular disease. ..
  4. Deudero J, Caramelo C, Castellanos M, Neria F, Fernandez Sanchez R, Calabia O, et al. Induction of hypoxia-inducible factor 1alpha gene expression by vascular endothelial growth factor. J Biol Chem. 2008;283:11435-44 pubmed publisher
    ..This effect is principally mediated by superoxide anion, therefore identifying a new, potentially relevant role of reactive oxygen species in VEGF signaling. ..
  5. Nishimura R, Okuda K. Hypoxia is important for establishing vascularization during corpus luteum formation in cattle. J Reprod Dev. 2010;56:110-6 pubmed
    ..in angiogenesis in bovine CL, the present study investigated the mRNA and protein expressions of the HIF1 alpha subunit (HIF1A) and VEGF in bovine CL during the estrous cycle...
  6. Mattmiller S, Corl C, Gandy J, Loor J, Sordillo L. Glucose transporter and hypoxia-associated gene expression in the mammary gland of transition dairy cattle. J Dairy Sci. 2011;94:2912-22 pubmed publisher
    ..A better understanding of glucose uptake at the endothelial level may prove to be critical to improve glucose absorption from the blood for utilization by mammary epithelial cells. ..
  7. Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney Y, et al. High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway. J Mol Cell Cardiol. 2007;42:609-19 pubmed
    ..These results suggest that hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity. ..
  8. Michaud M, Robitaille G, Gratton J, Richard D. Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells. Arterioscler Thromb Vasc Biol. 2009;29:902-8 pubmed publisher
    ..Our results identify S1P as a novel and potent nonhypoxic activator of HIF-1. We believe that understanding the role played by HIF-1 in S1P gene regulation will have a strong impact on different aspects of vascular biology. ..
  9. Gross J, van Dorland H, Wellnitz O, Bruckmaier R. Glucose transport and milk secretion during manipulated plasma insulin and glucose concentrations and during LPS-induced mastitis in dairy cows. J Anim Physiol Anim Nutr (Berl). 2015;99:747-56 pubmed publisher
    ..During LPS-induced mastitis in combination with hypoglycaemia, mammary gland metabolism was more aligned to save glucose for the immune system compared to a situation without limited glucose availability during EuG. ..

More Information


  1. Berisha B, Schams D, Rodler D, Sinowatz F, Pfaffl M. Expression pattern of HIF1alpha and vasohibins during follicle maturation and corpus luteum function in the bovine ovary. Reprod Domest Anim. 2017;52:130-139 pubmed publisher
    The aim of this study was to characterize expression patterns of hypoxia-inducible factor-1alpha (HIF1A) and vasohibin family members (VASH1 and VASH2) during different stages of ovarian function in cow...