GGCX

Summary

Gene Symbol: GGCX
Description: gamma-glutamyl carboxylase
Alias: vitamin K-dependent gamma-carboxylase, peptidyl-glutamate 4-carboxylase, vitamin K gamma glutamyl carboxylase
Species: cow
Products:     GGCX

Top Publications

  1. Wu S, Cheung W, Frazier D, Stafford D. Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. Science. 1991;254:1634-6 pubmed
    ..3 percent identity with soybean seed lipoxygenase. Expression of the cloned cDNA resulted in an increase in carboxylase activity in microsomes of transfected cells compared to mock-transfected cells. ..
  2. Rehemtulla A, Roth D, Wasley L, Kuliopulos A, Walsh C, Furie B, et al. In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 1993;90:4611-5 pubmed
    ..These results demonstrate that the ability of CHO cells to modify glutamic acid residues to gamma-carboxyglutamic acid in secreted factor IX is not limited by the expression of the vitamin K-dependent gamma-carboxylase alone. ..