Gene Symbol: FLT1
Description: fms related tyrosine kinase 1
Alias: VEGFR1, vascular endothelial growth factor receptor 1, VEGF-receptor, flt-receptor, soluble VEGF receptor 1, vascular endothelial growth factor 1, vascular endothelial growth factor/vascular permeability factor receptor
Species: cow
Products:     FLT1

Top Publications

  1. Cai J, Jiang W, Grant M, Boulton M. Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1. J Biol Chem. 2006;281:3604-13 pubmed
    ..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis. ..
  2. Cai J, Ahmad S, Jiang W, Huang J, Kontos C, Boulton M, et al. Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells. Diabetes. 2003;52:2959-68 pubmed
    ..how PlGF, which is elevated in proliferative diabetic retinopathy and is a VEGF homolog that binds only to VEGF receptor (VEGFR)-1, promotes pathological angiogenesis...
  3. Salmeri M, Motta C, Anfuso C, Amodeo A, Scalia M, Toscano M, et al. VEGF receptor-1 involvement in pericyte loss induced by Escherichia coli in an in vitro model of blood brain barrier. Cell Microbiol. 2013;15:1367-84 pubmed publisher
    ..A better understanding of the mechanisms by which E. coli enter the nervous system and how bacteria alter the communication between endothelial cells and pericytes may provide exciting new insight for clinical intervention. ..
  4. Ma R, van Eijk M, Beever J, Guerin G, Mummery C, Lewin H. Comparative analysis of 82 expressed sequence tags from a cattle ovary cDNA library. Mamm Genome. 1998;9:545-9 pubmed
    ..With the cost of large-scale EST sequencing becoming more affordable, and the rapid expansion of DNA databases, it is likely that COMPASS will be a preferred strategy for high throughput comparative mapping. ..
  5. Neagoe P, Lemieux C, Sirois M. Vascular endothelial growth factor (VEGF)-A165-induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer. J Biol Chem. 2005;280:9904-12 pubmed
    ..effect is mediated by acute platelet-activating factor synthesis from endothelial cells upon the activation of VEGF receptor-2 (VEGFR-2) and its coreceptor, neuropilin-1 (NRP-1)...
  6. Gonzalez Pacheco F, Deudero J, Castellanos M, Castilla M, Alvarez Arroyo M, Yagüe S, et al. Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2. Am J Physiol Heart Circ Physiol. 2006;291:H1395-401 pubmed
    ..Cell viability, VEGF and VEGF receptor (VEGFR1 and VEGFR2) expression, and transcription factor activation were studied on transient exposure of ..
  7. Campos D, Papa P, Marques J, Garbelotti F, Fátima L, Artoni L, et al. Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term. Genet Mol Res. 2010;9:309-23 pubmed publisher
    ..Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates. ..
  8. Cai J, Chen Z, Ruan Q, Han S, Liu L, Qi X, et al. ?-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. J Biol Chem. 2011;286:42514-23 pubmed publisher
    ..endothelial cells by both (a) cleavage and intracellular translocation of a C-terminal fragment of VEGF receptor-1 (VEGFR1) and (b) inhibition of VEGF-induced phosphorylation of VEGFR1...
  9. Mandriota S, Menoud P, Pepper M. Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. J Biol Chem. 1996;271:11500-5 pubmed
    ..These results imply that TGF-beta 1 is a major regulator of the VEGF/Flk-1 signal transduction pathway in endothelial cells. ..

More Information


  1. Tasaki Y, Nishimura R, Shibaya M, Lee H, Acosta T, Okuda K. Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells. J Reprod Dev. 2010;56:223-9 pubmed
    ..in regulating bovine endometrial function locally, in experiment 1, we determined the expression of VEGF, VEGF receptor (VEGFR) 1 and VEGFR2 throughout the estrous cycle in endometrial tissues...
  2. Macias V, Pinzon C, Fierro F, Vergara M, Martinez D, Rosado A, et al. Identification of soluble forms of vascular endothelial growth factor receptors, sVEGFR-1 and sVEGFR-2, in bovine dominant follicles. Reprod Domest Anim. 2012;47:e39-42 pubmed publisher
    ..The changes of sVEGFR-1 and sVEGFR-2 with the age of the bovine dominant follicle indicate a physiological role in its growth and atresia. ..
  3. Shih S, Ju M, Liu N, Mo J, Ney J, Smith L. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci U S A. 2003;100:15859-64 pubmed
    ..TGF-beta1 potently induces VEGF receptor 1 (VEGFR-1) expression in endothelial cells and thereby prevents oxygen-induced vessel loss in vivo...
  4. Ortega Serrano P, Guzman A, Hernández Coronado C, Castillo Juarez H, Rosales Torres A. Reduction in the mRNA expression of sVEGFR1 and sVEGFR2 is associated with the selection of dominant follicle in cows. Reprod Domest Anim. 2016;51:985-991 pubmed publisher
    ..The biological effects of VEGF are regulated by two membrane receptors, VEGFR1 and VEGFR2, and two soluble receptors, sVEGFR1 and sVEGFR2, which play an antagonistic role...
  5. Ishida T, Noda K, Jomane F, Tokunaga T. Polymorphisms of RDH16 and VEGFR1 influence M. trapezius steatosis in Japanese Black carcass. Anim Sci J. 2017;88:1037-1041 pubmed publisher
    ..in retinol dehydrogenase 16 (RDH16), myoferlin (MYOF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2) on carcass-graded Musculus trapezius steatosis...