FGF2

Summary

Gene Symbol: FGF2
Description: fibroblast growth factor 2
Alias: BFGF, FGF-2, HBGF-2, fibroblast growth factor 2, basic fibroblast growth factor, fibroblast growth factor 2 (basic), heparin-binding growth factor 2
Species: cow
Products:     FGF2

Top Publications

  1. Abraham J, Whang J, Tumolo A, Mergia A, Fiddes J. Human basic fibroblast growth factor: nucleotide sequence, genomic organization, and expression in mammalian cells. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:657-68 pubmed
  2. Ueno N, Baird A, Esch F, Shimasaki S, Ling N, Guillemin R. Purification and partial characterization of a mitogenic factor from bovine liver: structural homology with basic fibroblast growth factor. Regul Pept. 1986;16:135-45 pubmed
    ..The purified material showed the same biological activity as pituitary basic fibroblast growth factor (FGF)...
  3. Gospodarowicz D, Baird A, Cheng J, Lui G, Esch F, Bohlen P. Isolation of fibroblast growth factor from bovine adrenal gland: physicochemical and biological characterization. Endocrinology. 1986;118:82-90 pubmed
  4. Chang P, Lu S, Lee C, Chen Y, Dugan T, Huang W, et al. Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res. 2008;102:933-41 pubmed publisher
    ..Hcy exerted time- and concentration-dependent (0 to 500 micromol/L) reduction of the mRNA and protein levels of FGF2, whereas vascular endothelial growth factor expression was not affected until Hcy reached a proapoptotic 500 ..
  5. Khatib H, Maltecca C, Monson R, Schutzkus V, Wang X, Rutledge J. The fibroblast growth factor 2 gene is associated with embryonic mortality in cattle. J Anim Sci. 2008;86:2063-7 pubmed publisher
    The objective of this study was to investigate the association of the fibroblast growth factor 2 (FGF2) gene with embryonic survival and fertilization rate in cattle...
  6. Esch F, Baird A, Ling N, Ueno N, Hill F, Denoroy L, et al. Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proc Natl Acad Sci U S A. 1985;82:6507-11 pubmed
    ..The complete primary structure of bovine pituitary basic fibroblast growth factor (FGF) and the amino-terminal amino acid sequence of bovine brain acidic FGF have been established by ..
  7. Li W, Nugent M, Zhao Y, Chau A, Li S, Chou I, et al. Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential. J Cell Biochem. 2003;88:152-64 pubmed
    ..Here we demonstrate that basic fibroblast growth factor (bFGF), a polypeptide which regulates proliferation, differentiation, and migration of a variety of ..
  8. Hayashi Y, Maeshima K, Goto F, Kojima I. Activin A as a critical mediator of capillary formation: interaction with the fibroblast growth factor action. Endocr J. 2007;54:311-8 pubmed
    ..When bovine aortic endothelial cells (BAEC) were cultured in a collagen gel, basic fibroblast growth factor (FGF-2) induced tube formation...
  9. Ueno N, Baird A, Esch F, Ling N, Guillemin R. Isolation of an amino terminal extended form of basic fibroblast growth factor. Biochem Biophys Res Commun. 1986;138:580-8 pubmed
    ..15 microM pepstatin A, and 1 mM EDTA) resulted in the isolation of two distinct forms of basic fibroblast growth factor. Partial characterization of both molecules showed one form to be identical to basic FGF(1-146) which ..

More Information

Publications37

  1. Campos D, Papa P, Marques J, Garbelotti F, Fátima L, Artoni L, et al. Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term. Genet Mol Res. 2010;9:309-23 pubmed publisher
    ..Placental growth and function depend on the growth of blood vessels; VEGF-A and bFGF are the most important factors controlling neovascularization and vascular permeability in the placenta...
  2. Abd Elmaksoud A, Vermehren M, Nützel F, Habermann F, Sinowatz F. Analysis of fibroblast growth factor 2 (FGF2) gene transcription and protein distribution in the bovine testis. Growth Factors. 2005;23:295-301 pubmed
    ..The expression of FGF2 was studied in the adult bovine testis using quantitative RT-PCR, RNA in situ hybridization, and ..
  3. Yang Q, Johnson S, Ealy A. Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. Biol Reprod. 2011;84:933-43 pubmed publisher
    ..Several uterine- and embryo-derived factors, including fibroblast growth factor-2 (FGF2), regulate IFNT production...
  4. Yang Q, Giassetti M, Ealy A. Fibroblast growth factors activate mitogen-activated protein kinase pathways to promote migration in ovine trophoblast cells. Reproduction. 2011;141:707-14 pubmed publisher
    ..extend our understanding of how FGFs may control peri-implantation development in ruminants, we determined whether FGF2 and FGF10 impact trophoblast cell migration...
  5. Li X, An H, Ellman M, Phillips F, Thonar E, Park D, et al. Action of fibroblast growth factor-2 on the intervertebral disc. Arthritis Res Ther. 2008;10:R48 pubmed publisher
    b>Fibroblast growth factor 2 (FGF2) is a growth factor that is immediately released after cartilage injury and plays a pivotal role in cartilage homeostasis...
  6. Fujiwara Y, Uesugi M, Saito T. Down-regulation of basic fibroblast growth factor production from cartilage by excessive mechanical stress. J Orthop Sci. 2005;10:608-13 pubmed
    We examined the effect of excessive stress on the production of basic fibroblast growth factor (bFGF) by bovine cartilage. Bovine articular carpal bone was harvested and cut into 1 cm thick slices horizontally...
  7. Bertolini J, Hearn M. Isolation, characterisation and tissue localisation of an N-terminal-truncated variant of fibroblast growth factor. Mol Cell Endocrinol. 1987;51:187-99 pubmed
    An additional form of basic fibroblast growth factor (FGF), possessing full biological activity, has been isolated from bovine pituitary extracts...
  8. Ueno N, Baird A, Esch F, Ling N, Guillemin R. Isolation and partial characterization of basic fibroblast growth factor from bovine testis. Mol Cell Endocrinol. 1987;49:189-94 pubmed
    A basic fibroblast growth factor (FGF) has been purified to homogeneity from bovine testis, using ammonium sulfate precipitation of the crude extract followed by three chromatographic steps, involving cation-exchange, heparin-Sepharose, ..
  9. Woad K, Hunter M, Mann G, Laird M, Hammond A, Robinson R. Fibroblast growth factor 2 is a key determinant of vascular sprouting during bovine luteal angiogenesis. Reproduction. 2012;143:35-43 pubmed publisher
    ..were determined by culturing mixed cell types from early bovine corpora lutea on fibronectin in the presence of FGF2 and VEGFA (6 h to 9 days)...
  10. Caldini R, Barletta E, Del Rosso M, Giovannelli L, Chevanne M. FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase. J Cell Physiol. 2005;202:125-34 pubmed
    ..We have analyzed whether poly(ADP-ribose) polymerase activity is involved in basic fibroblast growth factor (FGF2)-mediated upregulation of urokinase-type plasminogen activator (uPA) mRNA...
  11. Boswell B, Lein P, Musil L. Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells. Mol Biol Cell. 2008;19:2631-41 pubmed publisher
    ..Our results support a model in which the angular gradient in GJIC in the lens, and thus proper lens function, is dependent on signaling between the FGF and BMP pathways. ..
  12. Camozzi M, Rusnati M, Bugatti A, Bottazzi B, Mantovani A, Bastone A, et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem. 2006;281:22605-13 pubmed
    ..PTX3 binds fibroblast growth factor-2 (FGF2), inhibiting its pro-angiogenic and pro-restenotic activity...
  13. Lim W, Bae H, Bazer F, Song G. Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy. Biol Reprod. 2017;96:185-198 pubmed publisher
    b>Fibroblast growth factor 2 (FGF2) is a mitogen that induces proliferation, differentiation, and migration of cells, as well as angiogenesis and carcinogenesis via autocrine or paracrine actions...
  14. Farberov S, Meidan R. Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells. Biol Reprod. 2014;91:58 pubmed publisher
    ..b>Fibroblast growth factor 2 (FGF2) and thrombospondins (THBSs) exhibited the most divergent profile of induction by PGF2alpha...
  15. Wu J, Ding Y, Bi Y, Wang Y, Zhi Y, Wang J, et al. Staphylococcus aureus induces TGF-β1 and bFGF expression through the activation of AP-1 and NF-κB transcription factors in bovine mammary gland fibroblasts. Microb Pathog. 2016;95:7-14 pubmed publisher
    ..receptor 2 (TLR2), toll-like receptor 4 (TLR4), transforming growth factor beta 1 (TGF-β1), basic fibroblast growth factor (bFGF) as well as the protein expression of nuclear factor-kappa B (NF-κB) and activation protein-1 ..
  16. Abraham J, Mergia A, Whang J, Tumolo A, Friedman J, Hjerrild K, et al. Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science. 1986;233:545-8 pubmed
    ..Both growth factors seem to be synthesized with short amino-terminal extensions that are not found on the isolated forms for which the amino acid sequences have been determined. Neither basic nor acidic FGF has a classic signal peptide. ..
  17. Robinson R, Nicklin L, Hammond A, Schams D, Hunter M, Mann G. Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow. Biol Reprod. 2007;77:28-36 pubmed
    ..In the present study, we examined the temporal changes in vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) during the follicular-luteal ..
  18. Michael D, Alvarez I, Ocón O, Powell A, Talbot N, Johnson S, et al. Fibroblast growth factor-2 is expressed by the bovine uterus and stimulates interferon-tau production in bovine trophectoderm. Endocrinology. 2006;147:3571-9 pubmed
    ..The magnitude by which FGF-2 stimulates IFNT expression suggests that this uterine-derived factor plays an active role in regulating the establishment and maintenance of pregnancy in ruminants. ..
  19. Neuvians T, Schams D, Berisha B, Pfaffl M. Involvement of pro-inflammatory cytokines, mediators of inflammation, and basic fibroblast growth factor in prostaglandin F2alpha-induced luteolysis in bovine corpus luteum. Biol Reprod. 2004;70:473-80 pubmed
    ..IL-1beta), and interferon gamma (IFNgamma), and of the inducible nitric oxide synthase (iNOS) and the basic fibroblast growth factor (FGF-2) during prostaglandin (PG) F(2alpha)-induced luteolysis in the bovine corpus luteum (CL)...
  20. Yamashita H, Kamada D, Shirasuna K, Matsui M, Shimizu T, Kida K, et al. Effect of local neutralization of basic fibroblast growth factor or vascular endothelial growth factor by a specific antibody on the development of the corpus luteum in the cow. Mol Reprod Dev. 2008;75:1449-56 pubmed publisher
    ..b>Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are known to stimulate angiogenesis and P ..
  21. Cucina A, Borrelli V, Randone B, Coluccia P, Sapienza P, Cavallaro A. Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells. J Surg Res. 2003;109:16-23 pubmed
    ..The release and mRNA expression of basic fibroblast growth factor (bFGF) and transforming growth factor beta(1) (TGFbeta(1)) were assessed by ELISA and PCR analysis...
  22. Orzechowski A, Gajkowska B, Wojewodzka U, Cassar Malek I, Picard B, Hocquette J. Immunohistochemical analysis of bFGF, TGF-beta1 and catalase in rectus abdominis muscle from cattle foetuses at 180 and 260 days post-conception. Tissue Cell. 2002;34:416-26 pubmed
    ..The aim of this study was the quantification by immunochemistry of basic fibroblast growth factor (bFGF) and transforming growth factor beta 1 (TGF-beta1) and also of enzyme catalase (CAT) activity in ..
  23. Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Res Vet Sci. 2011;91:235-9 pubmed publisher
    The objective of this study was to investigate the association of polymorphisms at the STAT5A and FGF2 gene loci with fertility, lactation milk yield and lameness in dairy cattle...
  24. Baird A, Esch F, Bohlen P, Ling N, Gospodarowicz D. Isolation and partial characterization of an endothelial cell growth factor from the bovine kidney: homology with basic fibroblast growth factor. Regul Pept. 1985;12:201-13 pubmed
  25. Lepique A, Moraes M, Rocha K, Eichler C, Hajj G, Schwindt T, et al. c-Myc protein is stabilized by fibroblast growth factor 2 and destabilized by ACTH to control cell cycle in mouse Y1 adrenocortical cells. J Mol Endocrinol. 2004;33:623-38 pubmed
    ..In this paper we compare ACTH and fibroblast growth factor 2 (FGF2) antagonistic effects on the cell cycle in the Y1 cell line, a functional lineage of mouse adreno-..
  26. Woad K, Hammond A, Hunter M, Mann G, Hunter M, Robinson R. FGF2 is crucial for the development of bovine luteal endothelial networks in vitro. Reproduction. 2009;138:581-8 pubmed publisher
    ..and involves the complex interplay between factors such as vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and platelet-derived growth factor (PDGF)...
  27. Lametsch R, Rasmussen J, Johnsen L, Purup S, Sejrsen K, Petersen T, et al. Structural characterization of the fibroblast growth factor-binding protein purified from bovine prepartum mammary gland secretion. J Biol Chem. 2000;275:19469-74 pubmed
    ..As the 10 cysteines of the three known FGF-BPs are positionally conserved, the disulfide bond pattern of bovine FGF-BP may be regarded as representative for the FGF-BP family. ..
  28. Bohlen P, Baird A, Esch F, Ling N, Gospodarowicz D. Isolation and partial molecular characterization of pituitary fibroblast growth factor. Proc Natl Acad Sci U S A. 1984;81:5364-8 pubmed
    ..This report describes a partial chemical characterization of a pituitary FGF and demonstrates rigorously that the characterized protein possesses the mitogenic activity commonly referred to as "basic pituitary FGF." ..