Gene Symbol: FDXR
Description: ferredoxin reductase
Alias: AdR, NADPH:adrenodoxin oxidoreductase, mitochondrial, adrenodoxin reductase, ferredoxin--NADP(+) reductase
Species: cow
Products:     FDXR

Top Publications

  1. Nonaka Y, Murakami H, Yabusaki Y, Kuramitsu S, Kagamiyama H, Yamano T, et al. Molecular cloning and sequence analysis of full-length cDNA for mRNA of adrenodoxin oxidoreductase from bovine adrenal cortex. Biochem Biophys Res Commun. 1987;145:1239-47 pubmed
    A full-length cDNA clone (pADR) for adrenodoxin reductase was isolated by means of immunological screening from a bovine adrenal poly(A)+ mRNA library...
  2. Warburton R, Seybert D. Structural and functional characterization of bovine adrenodoxin reductase by limited proteolysis. Biochim Biophys Acta. 1995;1246:39-46 pubmed
    Previously, we have proposed that bovine adrenocortical mitochondrial adrenodoxin reductase may possess a domain structure, based upon the generation of two major peptide fragments from limited tryptic proteolysis...
  3. Hanukoglu I, Gutfinger T. cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases. Eur J Biochem. 1989;180:479-84 pubmed
    b>Adrenodoxin reductase is an NADP dependent flavoenzyme which functions as the reductase of mitochondrial P 450 systems. We sequenced two adrenodoxin reductase cDNAs isolated from a bovine adrenal cortex cDNA library...
  4. Hamamoto I, Kurokohchi K, Tanaka S, Ichikawa Y. Adrenoferredoxin-binding peptide of NADPH-adrenoferredoxin reductase. Biochim Biophys Acta. 1988;953:207-13 pubmed
    ..The amino-acid sequence of the adrenoferredoxin-binding peptide was identified. The peptide accounted for 95% of the sugar content of the NADPH-adrenoferredoxin reductase. ..
  5. Sagara Y, Takata Y, Miyata T, Hara T, Horiuchi T. Cloning and sequence analysis of adrenodoxin reductase cDNA from bovine adrenal cortex. J Biochem. 1987;102:1333-6 pubmed
    cDNA clones for bovine adrenodoxin reductase were isolated, and the primary structure of the enzyme precursor was deduced from their nucleotide sequences...
  6. Takata Y, Sagara Y, Kono A, Sekimizu K, Horiuchi T. Gene structure of bovine adrenodoxin reductase. Biol Pharm Bull. 1993;16:1200-6 pubmed
    The gene structure of bovine adrenodoxin reductase, a component of the mitochondrial steroid hydroxylating system in the adrenal cortex, was determined...
  7. Zollner A, Nogues I, Heinz A, Medina M, Gomez Moreno C, Bernhardt R. Analysis of the interaction of a hybrid system consisting of bovine adrenodoxin reductase and flavodoxin from the cyanobacterium Anabaena PCC 7119. Bioelectrochemistry. 2004;63:61-5 pubmed
    ..Here we analyzed the interaction between bovine adrenodoxin reductase and flavodoxin from the cyanobacterium Anabaena PCC 7119...
  8. Ziegler G, Vonrhein C, Hanukoglu I, Schulz G. The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis. J Mol Biol. 1999;289:981-90 pubmed
    b>Adrenodoxin reductase is a monomeric 51 kDa flavoenzyme that is involved in the biosynthesis of all steroid hormones. The structure of the native bovine enzyme was determined at 2...
  9. Ziegler G, Schulz G. Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of an enzyme family. Biochemistry. 2000;39:10986-95 pubmed
    b>Adrenodoxin reductase is a flavoenzyme that shuffles electrons for the biosynthesis of steroids. Its chain topology belongs to the glutathione reductase family of disulfide oxidoreductases, all of which bind FAD at equivalent positions...

More Information


  1. Muller J, Lapko A, Bourenkov G, Ruckpaul K, Heinemann U. Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. J Biol Chem. 2001;276:2786-9 pubmed
    ..hydroxylating system of adrenal cortex mitochondria consists of the membrane-attached NADPH-dependent adrenodoxin reductase (AR), the soluble one-electron transport protein adrenodoxin (Adx), and a membrane-integrated cytochrome ..
  2. Derouet Hümbert E, Dragan C, Hakki T, Bureik M. ROS production by adrenodoxin does not cause apoptosis in fission yeast. Apoptosis. 2007;12:2135-42 pubmed
    ..pombe is either very robust to mitochondrial ROS production or does not undergo apoptotic cell death in response to mitochondrial ROS at all. ..
  3. Hanukoglu I, Gutfinger T, Haniu M, Shively J. Isolation of a cDNA for adrenodoxin reductase (ferredoxin-NADP+ reductase). Implications for mitochondrial cytochrome P-450 systems. Eur J Biochem. 1987;169:449-55 pubmed
    Using specific antibodies against adrenodoxin reductase (AR), we screened lambda gt11 cDNA expression libraries constructed from bovine adrenal cortex mRNA, and isolated several putative clones coding for this enzyme...