DGAT1

Summary

Gene Symbol: DGAT1
Description: diacylglycerol O-acyltransferase 1
Alias: ARAT, DGAT, diacylglycerol O-acyltransferase 1, acyl-CoA retinol O-fatty-acyltransferase, diacylglycerol O-acyltransferase homolog 1, diacylglycerol acyltransferase, diglyceride acyltransferase, retinol O-fatty-acyltransferase
Species: cow
Products:     DGAT1

Top Publications

  1. Banos G, Woolliams J, Woodward B, Forbes A, Coffey M. Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows. J Dairy Sci. 2008;91:3190-200 pubmed publisher
    ..polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly measures of ..
  2. Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, et al. Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res. 2002;12:222-31 pubmed
    ..the corresponding marker interval, (2) the demonstration that a very strong candidate gene, acylCoA:diacylglycerol acyltransferase (DGAT1), maps to that contig, and (3) the identification of a nonconservative K232A substitution in ..
  3. Winter A, Kramer W, Werner F, Kollers S, Kata S, Durstewitz G, et al. Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proc Natl Acad Sci U S A. 2002;99:9300-5 pubmed
    b>DGAT1 encodes diacylglycerol O-acyltransferase (EC ), a microsomal enzyme that catalyzes the final step of triglyceride synthesis...
  4. Kuhn C, Thaller G, Winter A, Bininda Emonds O, Kaupe B, Erhardt G, et al. Evidence for multiple alleles at the DGAT1 locus better explains a quantitative trait locus with major effect on milk fat content in cattle. Genetics. 2004;167:1873-81 pubmed
    ..studies have identified the nonconservative mutation K232A in the acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene as likely to be causal for the observed variation...
  5. Schennink A, Stoop W, Visker M, Heck J, Bovenhuis H, van Der Poel J, et al. DGAT1 underlies large genetic variation in milk-fat composition of dairy cows. Anim Genet. 2007;38:467-73 pubmed
    ..We genotyped 1762 cows for the DGAT1 K232A polymorphism, which is known to affect milk-fat percentage, to study the effect of the polymorphism on milk-..
  6. Grisart B, Farnir F, Karim L, Cambisano N, Kim J, Kvasz A, et al. Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition. Proc Natl Acad Sci U S A. 2004;101:2398-403 pubmed
    ..a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait locus (..
  7. Rosse I, Steinberg R, Coimbra R, Peixoto M, Verneque R, Machado M, et al. Novel SNPs and INDEL polymorphisms in the 3'UTR of DGAT1 gene: in silico analyses and a possible association. Mol Biol Rep. 2014;41:4555-63 pubmed publisher
    Diacylglycerol-O-acyltransferase (DGAT1) gene encodes the rate-limiting enzyme of triglyceride synthesis. A polymorphism in this gene, DGAT1 K232A, has been associated with milk production and composition in taurine breeds...
  8. Yuan Z, Li J, Li J, Gao X, Gao H, Xu S. Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle. Mol Biol Rep. 2013;40:1947-54 pubmed publisher
    ..candidate single nucleotide polymorphisms (SNPs) in the exon's region of bovine diacylglycerol O-acyltransferase (DGAT1) gene using bioinformatics and experimental methods...
  9. Oikonomou G, Angelopoulou K, Arsenos G, Zygoyiannis D, Banos G. The effects of polymorphisms in the DGAT1, leptin and growth hormone receptor gene loci on body energy, blood metabolic and reproductive traits of Holstein cows. Anim Genet. 2009;40:10-7 pubmed publisher
    The objective of this study was to examine the impact of polymorphisms in the acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total body energy content and ..

More Information

Publications39

  1. Conte G, Mele M, Chessa S, Castiglioni B, Serra A, Pagnacco G, et al. Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. J Dairy Sci. 2010;93:753-63 pubmed publisher
    ..of several fatty acids (FA) in the cis-Delta(9) position in mammary glands of ruminant animals, diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol synthesis in the mammary gland, and sterol regulatory ..
  2. Smaragdov M. [Association of the DGAT1 gene polymorphism in stud bulls with milk productivity in cows]. Genetika. 2011;47:126-32 pubmed
    The substitution of lysine for alanine (K232A) in the acyl-CoA-diacylglycerol acyltransferase, which is encoded by the DGAT1 gene, was tested for the significance for breeding evaluation of stud bulls of the holsteinized Black-and-White ..
  3. Gautier M, Capitan A, Fritz S, Eggen A, Boichard D, Druet T. Characterization of the DGAT1 K232A and variable number of tandem repeat polymorphisms in French dairy cattle. J Dairy Sci. 2007;90:2980-8 pubmed
    ..been identified with a high significance threshold value in the genomic region containing the acylCoA:diacylglycerol acyltransferase (DGAT1) gene, in the 3 main French dairy cattle breeds: French Holstein, Normande, and Montbéliarde...
  4. Tantia M, Vijh R, Mishra B, Mishra B, Kumar S, Sodhi M. DGAT1 and ABCG2 polymorphism in Indian cattle (Bos indicus) and buffalo (Bubalus bubalis) breeds. BMC Vet Res. 2006;2:32 pubmed
    ..Our objective was to estimate the frequency of K232A (DGAT1--diacylglycerol-acyltransferase 1) and Y581S (ABCG2--ATP binding cassette sub family G member 2) polymorphisms in ..
  5. Wu X, MacNeil M, De S, Xiao Q, Michal J, Gaskins C, et al. Evaluation of candidate gene effects for beef backfat via Bayesian model selection. Genetica. 2005;125:103-13 pubmed
    ..Diacyglycerol O-acyltransferase 1 (DGAT1), fatty acid binding protein (heart) 3 (FABP3), growth hormone 1 (GH1), leptin (LEP) and thyroglobulin (TG) have ..
  6. Sørensen B, Chris Kazala E, Murdoch G, Keating A, Cruz Hernandez C, Wegner J, et al. Effect of CLA and other C18 unsaturated fatty acids on DGAT in bovine milk fat biosynthetic systems. Lipids. 2008;43:903-12 pubmed publisher
    ..The effect of CLA and other FA on the expression of diacylglycerol acyltransferase-1 (DGAT-1) and DGAT-2, and DGAT activity were investigated in bovine mammary gland epithelial (MAC-T) ..
  7. Gorlov I, Fedunin A, Randelin D, Sulimova G. [Polymorphisms of bGH, RORC, and DGAT1 genes in Russian beef cattle breeds]. Genetika. 2014;50:1448-54 pubmed
    ..and genotypic polymorphisms of genes of the retinoic acid receptor-related orphan receptor C (RORC), diacylglycerol acyltransferase-1 (DGAT1), and growth hormone (bGH) in Russian beef cattle breeds in two populations of Kazakh white-..
  8. Kaupe B, Brandt H, Prinzenberg E, Erhardt G. Joint analysis of the influence of CYP11B1 and DGAT1 genetic variation on milk production, somatic cell score, conformation, reproduction, and productive lifespan in German Holstein cattle. J Anim Sci. 2007;85:11-21 pubmed
    ..in milk production traits on proximal BTA14, which cannot be explained solely with genetic variation in the DGAT1 gene...
  9. Bovenhuis H, Visker M, Poulsen N, Sehested J, van Valenberg H, van Arendonk J, et al. Effects of the diacylglycerol o-acyltransferase 1 (DGAT1) K232A polymorphism on fatty acid, protein, and mineral composition of dairy cattle milk. J Dairy Sci. 2016;99:3113-3123 pubmed publisher
    Several studies have described associations between the diacylglycerol o-acyltransferase 1 (DGAT1) K232A polymorphism and routinely collected milk production traits but not much is known about effects of the DGAT1 polymorphism on ..
  10. Yuan J, Zhou J, Deng X, Hu X, Li N. Molecular cloning and single nucleotide polymorphism detection of buffalo DGAT1 gene. Biochem Genet. 2007;45:611-21 pubmed
    We report molecular cloning and single nucleotide polymorphism detection of the buffalo DGAT1 gene. Diacylglycerol acyltransferase (DGAT1) is considered the key enzyme in controlling the rate of synthesis of triglycerides...
  11. Lehnert K, Ward H, Berry S, Ankersmit Udy A, Burrett A, Beattie E, et al. Phenotypic population screen identifies a new mutation in bovine DGAT1 responsible for unsaturated milk fat. Sci Rep. 2015;5:8484 pubmed publisher
    ..and genetic mapping and genome sequencing revealed a new mutation in a previously unknown splice enhancer of the DGAT1 gene...
  12. Tait R, Shackelford S, Wheeler T, King D, Keele J, Casas E, et al. CAPN1, CAST, and DGAT1 genetic effects on preweaning performance, carcass quality traits, and residual variance of tenderness in a beef cattle population selected for haplotype and allele equalization. J Anim Sci. 2014;92:5382-93 pubmed publisher
    ..CAPN1), a SNP in calpastatin (CAST), and a dinucleotide substitution in diacylglycerol O-acyltransferase 1 (DGAT1) were successfully selected to equalize their frequencies...
  13. Cardoso S, Queiroz L, Goulart V, Mourão G, Benedetti E, Goulart L. Productive performance of the dairy cattle Girolando breed mediated by the fat-related genes DGAT1 and LEP and their polymorphisms. Res Vet Sci. 2011;91:e107-12 pubmed publisher
    ..genes have been associated with milk production in bovines, such as the diacylglycerol O-acyltransferase 1 (DGAT1) and leptin (LEP); however, they have not been simultaneously investigated nor have been evaluated in the ..
  14. Niciura S, Ibelli A, Gouveia G, Gromboni J, Rocha M, de Souza M, et al. Polymorphism and parent-of-origin effects on gene expression of CAST, leptin and DGAT1 in cattle. Meat Sci. 2012;90:507-10 pubmed publisher
    ..CAST, related to meat tenderness, and DGAT1 and leptin, related to fat deposition, were evaluated...
  15. Molee A, Duanghaklang N, Na Lampang P. Effects of acyl-CoA:diacylglycerol acyl transferase 1 (DGAT1) gene on milk production traits in crossbred Holstein dairy cattle. Trop Anim Health Prod. 2012;44:751-5 pubmed publisher
    ..and investigate the genotype frequency and the association between Acyl-CoA:diacylglycerol acyltransferase1 gene, DGAT1 gene, and milk yield (MY), milk composition, protein yield (PY), fat yield (FY), solid not fat yield (SNF), total ..
  16. Carvajal A, Huircan P, Dezamour J, Subiabre I, Kerr B, Morales R, et al. Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation. Genet Mol Res. 2016;15: pubmed publisher
    ..Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated...
  17. Tăbăran A, Balteanu V, Gal E, Pusta D, Mihaiu R, Dan S, et al. Influence of DGAT1 K232A polymorphism on milk fat percentage and fatty acid profiles in Romanian holstein cattle. Anim Biotechnol. 2015;26:105-11 pubmed publisher
    ..Recently, a dinucleotide substitution located in the exon 8 of the gene coding for acyl CoA: diacylglycerol acyltransferase 1 (DGAT1), that alters the amino acid sequence from a lysine to an alanine (p...
  18. Kaupe B, Winter A, Fries R, Erhardt G. DGAT1 polymorphism in Bos indicus and Bos taurus cattle breeds. J Dairy Res. 2004;71:182-7 pubmed
    ..Recent reports name the acyl-CoA : diacylglycerol acyltransferase (DGAT1) gene on BTA14 as a potential candidate gene, with a nonconservative substitution of lysine by ..
  19. Sun D, Jia J, Ma Y, Wang Y, Yu Y, Zhang Y. Effects of DGAT1 and GHR on milk yield and milk composition in the Chinese dairy population. Anim Genet. 2009;40:997-1000 pubmed publisher
    Previous studies have demonstrated that the p.Lys232Ala substitution in the acylCoA: diacylglycerol acyltransferase (DGAT1) gene and the p...
  20. Kuehn C, Edel C, Weikard R, Thaller G. Dominance and parent-of-origin effects of coding and non-coding alleles at the acylCoA-diacylglycerol-acyltransferase (DGAT1) gene on milk production traits in German Holstein cows. BMC Genet. 2007;8:62 pubmed
    ..for alleles at the K232A and the promoter VNTR loci in the bovine acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene by using data sets including sires with accumulated phenotypic observations of daughters (breeding values, ..
  21. Lu C, Yang R, Shen B, Osman H, Zhang Y, Yan S, et al. RNA interference-mediated knockdown of DGAT1 decreases triglyceride content of bovine mammary epithelial cell line. Gene Expr. 2012;15:199-206 pubmed
    Diacylglyceroltransferase-1 (DGAT1) expresses in nearly all tissues, including the mammary gland...
  22. Mach N, Blum Y, Bannink A, Causeur D, Houee Bigot M, Lagarrigue S, et al. Pleiotropic effects of polymorphism of the gene diacylglycerol-O-transferase 1 (DGAT1) in the mammary gland tissue of dairy cows. J Dairy Sci. 2012;95:4989-5000 pubmed publisher
    ..Ala to Lys amino acid substitution at position 232 in exon VIII of the diacylglycerol-O-transferase 1 (DGAT1) gene...
  23. Duchemin S, Bovenhuis H, Stoop W, Bouwman A, van Arendonk J, Visker M. Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions. J Dairy Sci. 2013;96:592-604 pubmed publisher
    ..For this purpose, we estimated heritabilities, genetic correlations, effects of acyl-coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) K232A, and stearoyl-coenzyme A desaturase 1 (SCD1) A293V polymorphisms for milk fat ..
  24. Barbosa da Silva M, Sonstegard T, Thallman R, Connor E, Schnabel R, Van Tassell C. Characterization of DGAT1 allelic effects in a sample of North American Holstein cattle. Anim Biotechnol. 2010;21:88-99 pubmed publisher
    ..a lysine to alanine non-conservative substitution at amino acid 232 of the gene encoding the acylCoA:diacylglycerol acyltransferase (DGAT1) protein...
  25. Schennink A, Heck J, Bovenhuis H, Visker M, van Valenberg H, van Arendonk J. Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl CoA: diacylglycerol acyltransferase 1 (DGAT1). J Dairy Sci. 2008;91:2135-43 pubmed publisher
    ..46 +/- 0.09 for C16 index. We genotyped the cows for the SCD1 A293V and DGAT1 K232A polymorphisms, which are known to alter milk fatty acid composition...
  26. Naslund J, Fikse W, Pielberg G, Lunden A. Frequency and effect of the bovine acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) K232A polymorphism in Swedish dairy cattle. J Dairy Sci. 2008;91:2127-34 pubmed publisher
    Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol synthesis in the mammary gland, and the corresponding gene has emerged as a strong candidate for the variation in milk fat percentage...
  27. Glantz M, Lindmark Månsson H, Stålhammar H, Paulsson M. Effect of polymorphisms in the leptin, leptin receptor and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes and genetic polymorphism of milk proteins on bovine milk composition. J Dairy Res. 2012;79:110-8 pubmed publisher
    ..this study was to determine if polymorphisms in the leptin (LEP), leptin receptor (LEPR) and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) genes as well as genetic polymorphism of ?-casein (?-CN), ?-CN and ?-lactoglobulin (?-LG) ..
  28. Streit M, Neugebauer N, Meuwissen T, Bennewitz J. Short communication: evidence for a major gene by polygene interaction for milk production traits in German Holstein dairy cattle. J Dairy Sci. 2011;94:1597-600 pubmed publisher
    The present study investigated putative interaction effects between the DGAT1 K232A mutation and the polygenic term (i.e., all genes except DGAT1) for 5 milk production traits in the German Holstein dairy cattle population...
  29. Pannier L, Mullen A, Hamill R, Stapleton P, Sweeney T. Association analysis of single nucleotide polymorphisms in DGAT1, TG and FABP4 genes and intramuscular fat in crossbred Bos taurus cattle. Meat Sci. 2010;85:515-8 pubmed publisher
    ..studies have indicated that single nucleotide polymorphisms (SNPs) in the diacylglycerol-O-acyltransferase1 (DGAT1), thyroglobulin (TG) and adipose fatty acid binding protein (FABP4) genes are associated with intramuscular fat (..
  30. Demeter R, Schopen G, Lansink A, Meuwissen M, van Arendonk J. Effects of milk fat composition, DGAT1, and SCD1 on fertility traits in Dutch Holstein cattle. J Dairy Sci. 2009;92:5720-9 pubmed publisher
    ..of this study were to examine 1) the effect of milk fat composition, and 2) the effect of polymorphisms of DGAT1 and SCD1 genes on female fertility in commercial Dutch Holstein-Friesian cattle...