DCTN1

Summary

Gene Symbol: DCTN1
Description: dynactin subunit 1
Alias: dynactin subunit 1, dynactin 1 (p150, glued homolog, Drosophila)
Species: cow
Products:     DCTN1

Top Publications

  1. Payne C, St John J, Ramalho Santos J, Schatten G. LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte. Cell Motil Cytoskeleton. 2003;56:245-51 pubmed
    ..LIS1 is, therefore, essential to mediate genomic union in a process that involves the dynein-dynactin complex. These results shed light on an additional role for LIS1 and raise implications for human reproduction. ..
  2. Khanna H, Hurd T, Lillo C, Shu X, Parapuram S, He S, et al. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. J Biol Chem. 2005;280:33580-7 pubmed
    ..Taken together, these results provide novel evidence for the possible involvement of RPGR-ORF15 in microtubule organization and regulation of transport in primary cilia. ..
  3. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...