COL2A1

Summary

Gene Symbol: COL2A1
Description: collagen, type II, alpha 1
Alias: CB11, alpha-1 type II collagen, collagen alpha-1(II) chain, cyanogen bromide, pro-alpha 1(II)
Species: cow

Top Publications

  1. ncbi The covalent structure of cartilage collagen. Amino acid sequence of the NH2-terminal helical portion of the alpha 1 (II) chain
    W T Butler
    Biochemistry 15:3000-6. 1976
  2. ncbi Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi
    Geoffrey T Desmoulin
    Optima Health Solutions International Corporation KKT International, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 35:1437-44. 2010
  3. ncbi Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens
    I D C Jansen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and VU University, Research Institute MOVE, Amsterdam, The Netherlands
    J Mol Histol 41:9-17. 2010
  4. ncbi Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo
    S H Madsen
    Nordic Bioscience, Herlev, Denmark
    Scand J Rheumatol 38:222-6. 2009
  5. ncbi Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    S J Gilbert
    Cardiff University, Cardiff, Wales, UK
    Arthritis Rheum 58:209-20. 2008
  6. ncbi Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading
    R L Mauck
    Department of Health and Human Services Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, MSC 8022, Building 50, Bethesda, MD 20892 8022, USA
    Biomech Model Mechanobiol 6:113-25. 2007
  7. ncbi Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V
    Alain Colige
    Laboratory of Connective Tissues Biology, Center of Biomedical Integrative Genoproteomics, University of Liege, B 4000 SartTilman, Belgium
    J Biol Chem 280:34397-408. 2005
  8. ncbi Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry
    Yuekang Xu
    Department of Biochemistry and Molecular Biology, Box 13D, Monash University, Clayton 3800, Australia
    Mol Immunol 41:411-9. 2004
  9. ncbi Molecular definition and characterization of recombinant bovine CB8 and CB10: immunogenicity and arthritogenicity
    B Tang
    Departments of Pediatrics, Biochemistry and Medicine, University of Tennessee, Memphis, Tennessee, 38163, USA
    Clin Immunol 92:256-64. 1999
  10. ncbi Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly
    J J Wu
    Department of Orthopaedics, University of Washington, Seattle 98195, USA
    J Biol Chem 270:18865-70. 1995

Scientific Experts

  • Sophie J Gilbert
  • S H Madsen
  • I D C Jansen
  • Geoffrey T Desmoulin
  • R L Mauck
  • Alain Colige
  • Yuekang Xu
  • B Tang
  • D D Brand
  • X Yuan
  • R S Tuan
  • B A Byers
  • Isabel Vandenberghe
  • Frederic Kesteloot
  • Betty Nusgens
  • Alain Beschin
  • Florence Ruggiero
  • Jozef Van Beeumen
  • Lea Brys
  • Charles M Lapiere
  • Johanne Dubail
  • Marita Scealy
  • Rikard Holmdahl
  • Kutty Selva Nandakumar
  • Merrill J Rowley
  • Janet M Davies
  • A H Kang
  • Paul A Ramsland
  • L K Myers
  • J M Stuart
  • J J Wu
  • M L Gumanovskaya
  • T M Chiang
  • W T Butler
  • E J Miller
  • D R Eyre
  • E F Rosloniec
  • K Terato
  • K B Whittington
  • J E Finch
  • J M Seyer
  • F O Sangiorgi
  • W J de Wet
  • L G Lunde
  • K A Hasty
  • T Inagami
  • F Ramirez
  • V Benson-Chanda
  • M E Sobel

Detail Information

Publications18

  1. ncbi The covalent structure of cartilage collagen. Amino acid sequence of the NH2-terminal helical portion of the alpha 1 (II) chain
    W T Butler
    Biochemistry 15:3000-6. 1976
    ..The sequences of alpha 1 (II)-CB6, alpha 1 (II),-CB12, and 39 residues of alpha 1 (II)-CB11 were determined largely by automated Edman degradation...
  2. ncbi Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi
    Geoffrey T Desmoulin
    Optima Health Solutions International Corporation KKT International, Vancouver, British Columbia, Canada
    Spine (Phila Pa 1976) 35:1437-44. 2010
    ..5 g and 0 to 200 Hz. Expression of messenger ribonucleic acid for aggrecan, collagen type I, collagen type II, biglycan, decorin, and versican were assayed, as was apoptosis...
  3. ncbi Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens
    I D C Jansen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and VU University, Research Institute MOVE, Amsterdam, The Netherlands
    J Mol Histol 41:9-17. 2010
    ..Since type VI collagen is known to be relatively resistant to proteolysis we speculate that the higher level of type VI collagen in articular cartilage is important in protecting cartilage from digestion...
  4. ncbi Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo
    S H Madsen
    Nordic Bioscience, Herlev, Denmark
    Scand J Rheumatol 38:222-6. 2009
    ..This was performed in a cartilage model...
  5. ncbi Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway
    S J Gilbert
    Cardiff University, Cardiff, Wales, UK
    Arthritis Rheum 58:209-20. 2008
    ..The accumulation of ceramide is associated with arthritis in Farber's disease. The aim of this study was to investigate the mechanism of ceramide-induced down-regulation of type II collagen...
  6. ncbi Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading
    R L Mauck
    Department of Health and Human Services Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, MSC 8022, Building 50, Bethesda, MD 20892 8022, USA
    Biomech Model Mechanobiol 6:113-25. 2007
    ..These results demonstrate the utility of a new reporter promoter system for optimizing loading protocols to improve the outcome of engineered chondrocyte- and MSC-laden cartilaginous constructs...
  7. ncbi Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V
    Alain Colige
    Laboratory of Connective Tissues Biology, Center of Biomedical Integrative Genoproteomics, University of Liege, B 4000 SartTilman, Belgium
    J Biol Chem 280:34397-408. 2005
    ..This finding and the existence of multiple processed forms of ADAMTS-2 strongly suggest that ADAMTS-2 may be involved in function(s) other than processing of fibrillar procollagen types I-III...
  8. ncbi Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry
    Yuekang Xu
    Department of Biochemistry and Molecular Biology, Box 13D, Monash University, Clayton 3800, Australia
    Mol Immunol 41:411-9. 2004
    ....
  9. ncbi Molecular definition and characterization of recombinant bovine CB8 and CB10: immunogenicity and arthritogenicity
    B Tang
    Departments of Pediatrics, Biochemistry and Medicine, University of Tennessee, Memphis, Tennessee, 38163, USA
    Clin Immunol 92:256-64. 1999
    ..Thus, these recombinant CII peptides expressed in E. coli can induce an effective immunologic response and suggest that functionally useful CII peptides can be generated by the prokaryotic expression system...
  10. ncbi Structural analysis of cross-linking domains in cartilage type XI collagen. Insights on polymeric assembly
    J J Wu
    Department of Orthopaedics, University of Washington, Seattle 98195, USA
    J Biol Chem 270:18865-70. 1995
    ..N-propeptides in cartilage matrix and that the alpha 3 (XI) chain was the IIB splicing variant product of the COL2A1 gene...
  11. ncbi Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice
    D D Brand
    Department of Medicine, University of Tennessee, Memphis
    J Immunol 152:3088-97. 1994
    ..of bovine type II collagen (CII) that mediate the autoimmune response in H-2q mice, we have identified a cyanogen bromide fragment of bovine CII, CII(124-402), that induces arthritis in DBA/1 mice...
  12. ncbi Homologous regions of collagen alpha1(I) and alpha1(II) chains: apparent clustering of variable and invariant amino acid residues
    W T Butler
    Biochem Biophys Res Commun 57:190-5. 1974
  13. ncbi Isolation and characterization of the cyanogen bromide peptides from the alpha 1(II) chain of bovine and human cartilage collagen
    E J Miller
    Biochemistry 12:3153-9. 1973
  14. ncbi Covalent structure of collagen. Amino acid sequence of an arthritogenic cyanogen bromide peptide from type II collagen of bovine cartilage
    J M Seyer
    Connective Tissue Research Laboratory, Veterans Administration Medical Center, Memphis, TN 38104
    Eur J Biochem 181:159-73. 1989
    ..b>Cyanogen bromide digestion of purified type II collagen alpha chains yielded twelve distinct peptides designated CB1-12...
  15. ncbi Analysis of cDNA and genomic clones coding for the pro alpha 1 chain of calf type II collagen
    F O Sangiorgi
    Nucleic Acids Res 13:2815-26. 1985
    ..These clones span 23 kb of DNA and contain approximately 17 kb of the pro alpha 1(II) calf gene. Sequencing of exon 1 has determined the length of the 3' untranslated region and the exact location of the polyadenylation attachment site...
  16. ncbi The covalent structure of cartilage collagen. Evidence for sequence heterogeneity of bovine alpha1(II) chains
    W T Butler
    J Biol Chem 252:639-43. 1977
    During studies on the amino acid sequence of bovine nasal cartilage collagen, the cyanogen bromide peptide alpha1(II)-CB11 was degraded to smaller peptides with trypsin...
  17. ncbi Disc strain and resulting positive mRNA expression from application of a noninvasive treatment
    Geoffrey T Desmoulin
    Optima Health Solutions International Corp, KKT International, Vancouver, BC, Canada
    Spine (Phila Pa 1976) 36:E921-8. 2011
    ..5 to 5 g and frequencies of 0, 16, 50 to 80, and a combined 16+50 to 80 Hz treatment. Expression of mRNA for aggrecan, collagen type I, collagen type II, biglycan, decorin, and versican were assayed...