Gene Symbol: CHRNA7
Description: cholinergic receptor, nicotinic, alpha 7
Alias: neuronal acetylcholine receptor subunit alpha-7, alpha 7 nicotinic acetylcholine receptor, cholinergic receptor, nicotinic, alpha polypeptide 7
Criado M, Castillo M, Mulet J, Sala F, Sala S. Role of loop 9 on the function of neuronal nicotinic receptors. Biochim Biophys Acta. 2010;1798:654-9 pubmed publisher
..In contrast, heteromeric receptor alpha3beta4 with the same mutations retained some function. We conclude that loop 9 has a different role in the function of homomeric and heteromeric receptors. ..
Maneu V, Gerona G, Fernandez L, Cuenca N, Lax P. Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells. Vis Neurosci. 2010;27:139-47 pubmed publisher
..These results suggest that nAChRs could have a significant role in RPE, which may not be related to the traditional role in nerve transmission but could more likely be related to the nonneuronal cholinergic system in the eye. ..
Criado M, Mulet J, Castillo M, Gerber S, Sala S, Sala F. The loop between beta-strands beta 2 and beta 3 and its interaction with the N-terminal alpha-helix is essential for biogenesis of alpha 7 nicotinic receptors. J Neurochem. 2010;112:103-11 pubmed publisher
..We conclude that loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly. ..
Alves D, Castello Banyuls J, Faura C, Ballesta J. An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors. FEBS Lett. 2011;585:1169-74 pubmed publisher
..We conclude that a pre-M1 RRR motif is necessary for the biogenesis of homomeric ?-bungarotoxin-sensitive neuronal ?7 nicotinic ACh receptors. ..
Criado M, Mulet J, Gerber S, Sala S, Sala F. A small cytoplasmic region adjacent to the fourth transmembrane segment of the ?7 nicotinic receptor is essential for its biogenesis. FEBS Lett. 2011;585:2477-80 pubmed publisher
..Hence, elements in this cytoplasmic fragment might influence receptor transport to the membrane...
Maneu V, Rojo J, Mulet J, Valor L, Sala F, Criado M, et al
. A single neuronal nicotinic receptor alpha3alpha7beta4* is present in the bovine chromaffin cell. Ann N Y Acad Sci. 2002;971:165-7 pubmed
Sala F, Mulet J, Sala S, Gerber S, Criado M. Charged amino acids of the N-terminal domain are involved in coupling binding and gating in alpha7 nicotinic receptors. J Biol Chem. 2005;280:6642-7 pubmed
..Rather, a network of interactions formed by residues Lys-46, Asp-128, Asp-135, Asp-266, and possibly others appears to link agonist binding to channel gating. ..
Bernal J, Mulet J, Castillo M, Criado M, Sala S, Sala F. Binding-gating coupling in a nondesensitizing alpha7 nicotinic receptor A single channel pharmacological study. Biochim Biophys Acta. 2009;1788:410-6 pubmed publisher
..Nevertheless, its extensively altered pharmacology precludes the simple extrapolation of pharmacological data obtained in singly mutated alpha7 receptors. ..
Criado M, Mulet J, Bernal J, Gerber S, Sala S, Sala F. Mutations of a conserved lysine residue in the N-terminal domain of alpha7 nicotinic receptors affect gating and binding of nicotinic agonists. Mol Pharmacol. 2005;68:1669-77 pubmed
..The results are compatible with the involvement of Lys145 in the early steps of channel activation by acetylcholine. ..