Gene Symbol: CD8A
Description: CD8a molecule
Alias: T-cell surface glycoprotein CD8 alpha chain, CD8 antigen, alpha polypeptide (p32)
Species: cow
Products:     CD8A

Top Publications

  1. Lalor P, Bucci C, Fornaro M, Rattazzi M, Nakauchi H, Herzenberg L, et al. Molecular cloning, reconstruction and expression of the gene encoding the alpha-chain of the bovine CD8--definition of three peptide regions conserved across species. Immunology. 1992;76:95-102 pubmed
    ..The latter result formally proves that the ILA-51 antibody does indeed recognize the product of the BoCD8 alpha gene, as previously suggested on serological grounds. ..
  2. Lin R, Rodriguez C, Veillette A, Lodish H. Zinc is essential for binding of p56(lck) to CD4 and CD8alpha. J Biol Chem. 1998;273:32878-82 pubmed
    ..p56(lck) complexes. CD4. p56(lck) and CD8alpha.p56(lck) represent the first examples of intracellular proteins that require zinc as a bridge for heterodimerization. ..
  3. Allam A, Illges H. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Immunobiology. 2000;202:353-62 pubmed
    ..The effect was specific to CD8alpha in that CD4 expression was not affected and specific for calyculin A. Okadaic acid, another phosphatase inhibitor did not show any influence on the expression of CD4 or CD8. ..
  4. Parnes J. Molecular biology and function of CD4 and CD8. Adv Immunol. 1989;44:265-311 pubmed