CAPN3

Summary

Gene Symbol: CAPN3
Description: calpain 3
Alias: SKM-CALP, calpain-3, CANP 3, calcium-activated neutral proteinase 3, calpain 3, (p94), calpain L3, calpain p94, muscle-specific calcium-activated neutral protease 3, muscle-specific calpain, nCL-1, new calpain 1, skeletal muscle-specific calpain
Species: cow

Top Publications

  1. Ilian M, Morton J, Kent M, Le Couteur C, Hickford J, Cowley R, et al. Intermuscular variation in tenderness: association with the ubiquitous and muscle-specific calpains. J Anim Sci. 2001;79:122-32 pubmed
    ..The mRNA level of bovine calpain 3 was significantly higher in the LT muscle than in the PM...
  2. Ilian M, Morton J, Bekhit A, Roberts N, Palmer B, Sorimachi H, et al. Effect of preslaughter feed withdrawal period on longissimus tenderness and the expression of calpains in the ovine. J Agric Food Chem. 2001;49:1990-8 pubmed
    ..to generate differences in meat tenderness and to determine in tandem the expression of calpain 1, calpain 2, calpain 3, and calpastatin...
  3. Barendse W, Harrison B, Bunch R, Thomas M. Variation at the Calpain 3 gene is associated with meat tenderness in zebu and composite breeds of cattle. BMC Genet. 2008;9:41 pubmed publisher
    ..Here we examine variation at the Calpain 3 (CAPN3) gene in cattle, a gene located within the confidence interval of the QTL, and which is a positional ..
  4. Roperto S, De Tullio R, Raso C, Stifanese R, Russo V, Gaspari M, et al. Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle. PLoS ONE. 2010;5:e10299 pubmed publisher
    b>Calpain 3 (Capn3), also named p94, is a skeletal muscle tissue-specific protein known to be responsible for limb-girdle muscular dystrophy type 2A (LGMD2A)...
  5. Robinson D, Cafe L, McIntyre B, Geesink G, Barendse W, Pethick D, et al. Production and processing studies on calpain-system gene markers for beef tenderness: consumer assessments of eating quality. J Anim Sci. 2012;90:2850-60 pubmed publisher
    ..at weaning from commercial and research herds to achieve balance and divergence in calpastatin (CAST) and calpain 3 (CAPN3) gene marker status. Genotypes for ?-calpain (CAPN1-4751 and CAPN1-316) were also determined...
  6. Liu S, Jiang H, Yuan B, Gao Y, Dai L, Zhang J. Characterization of a novel CAPN3 transcript generated by alternative splicing in cattle. Genet Mol Res. 2015;14:457-63 pubmed publisher
    Calpain-3 (CAPN3) is a member of the calpain family of Ca(2+)-regulated cysteine proteases, which play an important role in sarcomere remodeling and mitochondrial protein turnover, and thus, regulating beef tenderness in cattle...
  7. Nonneman D, Koohmaraie M. Molecular cloning and mapping of the bovine and ovine skeletal muscle-specific calpains. Anim Genet. 1999;30:456-8 pubmed
    ..72. The observed heterozygosity was 50% for both CANP3 markers in bovine and sheep pedigrees. ..